Disease Systems Biology Program

2021

Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

Forstner, A. J., Awasthi, S., Wolf, C., Maron, E., Erhardt, A., Czamara, D., Eriksson, E., Lavebratt, C., Allgulander, C., Friedrich, N., Becker, J., Hecker, J., Rambau, S., Conrad, R., Geiser, F., Mcmahon, F. J., Moebus, S., Hess, T., Buerfent, B. C., Hoffmann, P., & 55 othersHerms, S., Heilmann-heimbach, S., Kockum, I., Olsson, T., Alfredsson, L., Weber, H., Alpers, G. W., Arolt, V., Fehm, L., Fydrich, T., Gerlach, A. L., Hamm, A., Kircher, T., Pané-farré, C. A., Pauli, P., Rief, W., Ströhle, A., Plag, J., Lang, T., Wittchen, H., Mattheisen, M., Meier, S., Metspalu, A., Domschke, K., Reif, A., Hovatta, I., Lindefors, N., Andersson, E., Schalling, M., Mbarek, H., Milaneschi, Y., De Geus, E. J. C., Boomsma, D. I., Penninx, B. W. J. H., Thorgeirsson, T. E., Steinberg, S., Stefansson, K., Stefansson, H., Müller-myhsok, B., Hansen, T. F., Børglum, A. D., Werge, T., Mortensen, P. B., Nordentoft, M., Hougaard, D. M., Hultman, C. M., Sullivan, P. F., Nöthen, M. M., Woldbye, D. P. D., Mors, O., Binder, E. B., Rück, C., Ripke, S., Deckert, J. & Schumacher, J., Aug 2021, In: Molecular Psychiatry. 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

2020

CoCoScore: Context-aware co-occurrence scoring for text mining applications using distant supervision

Junge, A. & Jensen, L. J., 1 Jan 2020, In: Bioinformatics. 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

3 Downloads (Pure)

Conflicting associations between dietary patterns and changes of anthropometric traits across subgroups of middle-aged women and men

Jiang, L., Audouze, K., Romero Herrera, J. A., Ängquist, L. H., Kjærulff, S. K., Izarzugaza, J. M. G., Tjønneland, A., Halkjær, J., Overvad, K., Sørensen, T. I. A. & Brunak, S., Jan 2020, In: Clinical Nutrition.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

2019

A Brief History of Protein Sorting Prediction

Nielsen, H., Tsirigos, K. D., Brunak, S. & von Heijne, G., 15 Jun 2019, In: The Protein Journal. 38, 3, p. 200-216

Research output: Contribution to journal › Review › peer-review

26 Citations (Scopus)

18 Downloads (Pure)

A generic deep convolutional neural network framework for prediction of receptor–ligand interactions - NetPhosPan: application to kinase phosphorylation prediction

Fenoy, E., Izarzugaza, J. M. G., Jurtz, V., Brunak, S. & Nielsen, M., 1 Apr 2019, In: Bioinformatics. 35, 7, p. 1098-1107

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

A Guide to Dictionary-Based Text Mining

Cook, H. V. & Jensen, L. J., 2019, Bioinformatics and Drug Discovery. Larson, R. S. & Oprea, T. I. (eds.). 3 ed. Humana Press, Vol. 1939. p. 73-89 17 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

6 Citations (Scopus)

A large-cohort, longitudinal study determines pre-cancer disease routes across different cancer types

Hu, J. X., Helleberg, M., Jensen, A. B., Brunak, S. & Lundgren, J., 15 Feb 2019, In: Cancer Research. 79, 4, p. 864-872

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation

Hansen, B. K., Gupta, R., Baldus, L., Lyon, D., Narita, T., Lammers, M., Choudhary, C. & Weinert, B. T., 1 Dec 2019, In: Nature Communications. 10, 11 p., 1055.

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

31 Downloads (Pure)

Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism

Cuesta-Astroz, Y., Santos, A., Oliveira, G. & Jensen, L. J., 2019, In: Frontiers in Immunology. 10, 17 p., 212.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

18 Downloads (Pure)

BioReader: a text mining tool for performing classification of biomedical literature

Simon, C., Davidsen, K., Hansen, C., Seymour, E., Barnkob, M. B. & Olsen, L. R., 4 Feb 2019, In: BMC Bioinformatics. 19, Suppl. 13, 6 p., 57.

Research output: Contribution to journal › Conference article › Research › peer-review

11 Citations (Scopus)

17 Downloads (Pure)

Bone Status in Obese, Non-diabetic, Antipsychotic-Treated Patients, and Effects of the Glucagon-Like Peptide-1 Receptor Agonist Exenatide on Bone Turnover Markers and Bone Mineral Density

Eriksson, R., Broberg, B. V., Ishoy, P. L., Bak, N., Andersen, U. B., Jorgensen, N. R., Knop, F. K. & Ebdrup, B. H., 2019, In: Frontiers in Psychiatry. 9, 7 p., 781.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

22 Downloads (Pure)

Combined Ensemble Docking and Machine Learning in Identification of Therapeutic Agents with Potential Inhibitory Effect on Human CES1

Briand, E., Thomsen, R., Linnet, K., Rasmussen, H. B., Brunak, S. & Taboureau, O., 29 Jul 2019, In: Molecules. 24, 15, 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

26 Downloads (Pure)

Combing the Hairball: Improving Visualization of miRNA-Target Interaction Networks

Russo, F., Hu, J. X., Romero Herrera, J. A. & Brunak, S., 2019, MicroRNA Target Identification: Methods and Protocols. Laganà, A. (ed.). Humana Press, p. 279-289 11 p. (Methods in Molecular Biology, Vol. 1970).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Comorbidity landscape of the Danish patient population affected by chromosome abnormalities

Jørgensen, I. F., Russo, F., Jensen, A. B., Westergaard, D., Lademann, M., Hu, J. X., Brunak, S. & Belling, K., 1 Nov 2019, In: Genetics In Medicine. 21, 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

2 Downloads (Pure)

Comparing migraine with and without aura to healthy controls using RNA sequencing

Kogelman, L. J. A., Falkenberg, K., Halldorsson, G. H., Poulsen, L. U., Worm, J., Ingason, A., Stefansson, H., Stefansson, K., Hansen, T. F. & Olesen, J., 1 Oct 2019, In: Cephalalgia. 39, 11, p. 1435-1444

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq

Gådin, J. R., Buil, A., Colantuoni, C., Jaffe, A. E., Nielsen, J., Shin, J-H., Hyde, T. M., Kleinman, J. E., Plath, N., Eriksson, P., Brunak, S., Didriksen, M., Weinberger, D. R., Folkersen, L. & BrainSeq Consortium, Jun 2019, In: PLoS ONE. 14, 6, 16 p., e0217765.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Downloads (Pure)

Contaminating viral sequences in high-throughput sequencing viromics: a linkage study of 700 sequencing libraries

Asplund, M., Kjartansdóttir, K. R., Mollerup, S., Vinner, L., Fridholm, H., Herrera, J. A. R., Friis-Nielsen, J., Hansen, T. A., Jensen, R. H., Nielsen, I. B., Richter, S. R., Rey-Iglesia, A., Matey-Hernandez, M. L., Alquezar-Planas, D. E., Olsen, P. V. S., Sicheritz-Pontén, T., Willerslev, E., Lund, O., Brunak, S., Mourier, T., & 3 othersNielsen, L. P., Izarzugaza, J. M. G. & Hansen, A. J., Oct 2019, In: Clinical Microbiology and Infection. 25, 10, p. 1277-1285

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

16 Downloads (Pure)

Cyprus Women's Health Research (COHERE) initiative: determining the relative burden of women's health conditions and related co-morbidities in an Eastern Mediterranean population

Hocaoglu, M. B., Gurkas, S., Karaderi, T., Taneri, B., Erguler, K., Barin, B., Bilgin, E. M., Eralp, G., Allison, M., Findikli, N., Boynukalin, K., Bahceci, M., Naci, H., Vincent, K., Missmer, S. A., Becker, C. M., Zondervan, K. T. & Rahmioglu, N., 3 Apr 2019, In: BMC Women's Health. 19, 7 p., 50.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Downloads (Pure)

Cytoscape stringApp: Network analysis and visualization of proteomics data

Doncheva, N. T., Morris, J., Gorodkin, J. & Jensen, L. J., 1 Feb 2019, In: Journal of Proteome Research. 18, 2, p. 623-632

Research output: Contribution to journal › Journal article › Research › peer-review

204 Citations (Scopus)

DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors

Hansen, T. F., Banasik, K., Erikstrup, C., Pedersen, O. B., Westergaard, D., Chmura, P. J., Nielsen, K., Thørner, L., Hjalgrim, H., Paarup, H., Larsen, M. A. H., Petersen, M., Jennum, P., Andersen, S., Nyegaard, M., Jemec, G. B. E., Olesen, J., Werge, T., Johansson, P. I., Sørensen, E., & 3 othersBrunak, S., Ullum, H. & Burgdorf, K. S., 1 Jun 2019, In: BMJ Open. 9, 6, p. 1-7 7 p., e028401.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

12 Downloads (Pure)

Design, implementation, and operation of a rapid, robust named entity recognition web service

Pletscher-Frankild, S. & Jensen, L. J., 2019, In: Journal of Cheminformatics. 11, 6 p., 19.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

25 Downloads (Pure)

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A., Perry, M. H., & 31 othersRauh, S. P., Ridderstråle, M., Teare, H. J. A., Thomas, E. L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J. D., Beulens, J. W., Brunak, S., Dermitzakis, E. T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T. J., Pedersen, O., Schwenk, J. M., Pavo, I., Mari, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E., Franks, P. W. & IMI-DIRECT consortium, 1 Sept 2019, In: Diabetologia. 62, 9, p. 1601-1615

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

24 Downloads (Pure)

Distinct signatures of lung cancer types: aberrant mucin O-glycosylation and compromised immune response

Lucchetta, M., da Piedade, I., Mounir, M., Vabistsevits, M., Terkelsen, T. & Papaleo, E., 20 Aug 2019, In: BMC Cancer. 19, 824.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

8 Downloads (Pure)

Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny

Cappellini, E., Welker, F., Pandolfi, L., Ramos-Madrigal, J., Samodova, D., Rüther, P. L., Fotakis, A. K., Lyon, D., Moreno-Mayar, J. V., Bukhsianidze, M., Rakownikow Jersie-Christensen, R., Mackie, M., Ginolhac, A., Ferring, R., Tappen, M., Palkopoulou, E., Dickinson, M. R., Stafford, T. W., Chan, Y. L., Götherström, A., & 23 othersNathan, S. K. S. S., Heintzman, P. D., Kapp, J. D., Kirillova, I., Moodley, Y., Agusti, J., Kahlke, R. D., Kiladze, G., Martínez-Navarro, B., Liu, S., Sandoval Velasco, M., Sinding, M. H. S., Kelstrup, C. D., Allentoft, M. E., Orlando, L., Penkman, K., Shapiro, B., Rook, L., Dalén, L., Gilbert, M. T. P., Olsen, J. V., Lordkipanidze, D. & Willerslev, E., 3 Oct 2019, In: Nature. 574, 7776, p. 103-107 5 p.

Research output: Contribution to journal › Letter › peer-review

44 Citations (Scopus)

eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses

Huerta-Cepas, J., Szklarczyk, D., Heller, D., Hernández-Plaza, A., Forslund, S. K., Cook, H., Mende, D. R., Letunic, I., Rattei, T., Jensen, L. J., von Mering, C. & Bork, P., 8 Jan 2019, In: Nucleic Acids Research. 47, D1, p. D309-D314 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

286 Citations (Scopus)

17 Downloads (Pure)

Estimating heritability and genetic correlations from large health datasets in the absence of genetic data

Jia, G., Li, Y., Zhang, H., Chattopadhyay, I., Jensen, A. B., Blair, D. R., Davis, L., Robinson, P. N., Dahlen, T., Brunak, S., Benson, M., Edgren, G., Cox, N. J., Gao, X. & Rzhetsky, A., 1 Dec 2019, In: Nature Communications. 10, 11 p., 5508.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

Spracklen, C. N., Karaderi, T., Yaghootkar, H., Schurmann, C., Fine, R. S., Kutalik, Z., Preuss, M. H., Lu, Y., Wittemans, L. B. L., Adair, L. S., Allison, M., Amin, N., Auer, P. L., Bartz, T. M., Blüher, M., Boehnke, M., Borja, J. B., Bork-Jensen, J., Broer, L., Chasman, D. I., & 31 othersChen, Y. D. I., Chirstofidou, P., Demirkan, A., van Duijn, C. M., Feitosa, M. F., Garcia, M. E., Graff, M., Grallert, H., Grarup, N., Guo, X., Haesser, J., Hansen, T., Harris, T. B., Highland, H. M., Hong, J., Ikram, M. A., Ingelsson, E., Jackson, R., Jousilahti, P., Kähönen, M., Kizer, J. R., Kovacs, P., Kriebel, J., Laakso, M., Lange, L. A., Lehtimäki, T., Li, J., Lind, L., Kilpeläinen, T. O., Loos, R. J. F. & Mohlke, K. L., 2019, In: American Journal of Human Genetics. 105, 1, p. 15-28 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

Wilman, H. R., Parisinos, C. A., Atabaki-Pasdar, N., Kelly, M., Thomas, E. L., Neubauer, S., Jennison, C., Ehrhardt, B., Baum, P., Schoelsch, C., Freijer, J., Grempler, R., Graefe-Mody, U., Hennige, A., Dings, C., Lehr, T., Scherer, N., Sihinecich, I., Pattou, F., Raverdi, V., & 31 othersCaiazzo, R., Torres, F., Verkindt, H., Mari, A., Tura, A., Giorgino, T., Bizzotto, Froguel, P., Brorsson, C., Brunak, S., De Masi, F., Pedersen, H., Banasik, K., Thomas, C., Lundgaard, A., Nielsen, A., Mazzoni, G., Karaderi, T., Rasmussen, S., Johansen, J., Allesøe, R., Arumugam, M., Allin, K., Hansen, T., Hansen, T., Jonsson, A., Pedersen, O., Dutta, A., Vogt, J., Vestergaard, H. & IMI-DIRECT consortium, 1 Sept 2019, In: Journal of Hepatology. 71, 3, p. 594-602 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

13 Downloads (Pure)

Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population

Nissen, J., Trabjerg, B., Pedersen, M. G., Banasik, K., Pedersen, O. B., Sørensen, E., Nielsen, K. R., Erikstrup, C., Petersen, M. S., Paarup, H. M., Bruun-Rasmussen, P., Westergaard, D., Hansen, T. F., Pedersen, C. B., Werge, T., Torrey, F., Hjalgrim, H., Mortensen, P. B., Yolken, R., Brunak, S., & 2 othersUllum, H. & Burgdorf, K. S., Oct 2019, In: Psychoneuroendocrinology. 108, p. 150-154

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

13 Downloads (Pure)

High-Throughput Sequencing-Based Investigation of Viruses in Human Cancers by Multienrichment Approach

Mollerup, S., Asplund, M., Friis-Nielsen, J., Kjartansdóttir, K. R., Fridholm, H., Hansen, T. A., Herrera, J. A. R., Barnes, C. J., Jensen, R. H., Richter, S. R., Nielsen, I. B., Pietroni, C., Alquezar-Planas, D. E., Rey-Iglesia, A., Olsen, P. V. S., Rajpert-De Meyts, E., Groth-Pedersen, L., von Buchwald, C., Jensen, D. H., Gniadecki, R., & 20 othersHøgdall, E., Langhoff, J. L., Pete, I., Vereczkey, I., Baranyai, Z., Dybkaer, K., Johnsen, H. E., Steiniche, T., Hokland, P., Rosenberg, J., Baandrup, U., Sicheritz-Pontén, T., Willerslev, E., Brunak, S., Lund, O., Mourier, T., Vinner, L., Izarzugaza, J. M. G., Nielsen, L. P. & Hansen, A. J., 13 Sept 2019, In: The Journal of Infectious Diseases. 220, 8, p. 1312-1324

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

20 Downloads (Pure)

Identification of Disease-miRNA Networks Across Different Cancer Types Using SWIM

Fiscon, G., Conte, F., Farina, L., Pellegrini, M., Russo, F. & Paci, P., 2019, MicroRNA Target Identification: Methods and Protocols. Laganà, A. (ed.). Humana Press, p. 169-181 13 p. (Methods in Molecular Biology, Vol. 1970).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

4 Citations (Scopus)

Identification of hyper-rewired genomic stress non-oncogene addiction genes across 15 cancer types

Hjaltelin, J. X., Izarzugaza, J. M. G., Jensen, L. J., Russo, F., Westergaard, D. & Brunak, S., 1 Dec 2019, In: npj Systems Biology and Applications. 5, 10 p., 27.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

7 Downloads (Pure)

Identifying Sepsis Phenotypes

Moseley, P. L. & Brunak, S., 8 Oct 2019, In: J A M A: The Journal of the American Medical Association. 322, 14, p. 1416-1417 2 p.

Research output: Contribution to journal › Comment/debate › Research

1 Citation (Scopus)

Immunity and mental illness: findings from a Danish population-based immunogenetic study of seven psychiatric and neurodevelopmental disorders

Nudel, R., Benros, M. E., Krebs, M. D., Allesøe, R. L., Lemvigh, C. K., Bybjerg-Grauholm, J., Børglum, A. D., Daly, M. J., Nordentoft, M., Mors, O., Hougaard, D. M., Mortensen, P. B., Buil, A., Werge, T., Rasmussen, S. & Thompson, W. K., 1 Sept 2019, In: European Journal of Human Genetics. 27, p. 1445-1455

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

19 Downloads (Pure)

Improving Peptide-Spectrum Matching by Fragmentation Prediction Using Hidden Markov Models

Kirik, U., Refsgaard, J. C. & Jensen, L. J., 7 Jun 2019, In: Journal of Proteome Research. 18, 6, p. 2385-2396

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Incorporating symptom data in longitudinal disease trajectories for more detailed patient stratification

Lademann, M., Lademann, M., Boeck Jensen, A. & Brunak, S., Sept 2019, In: International Journal of Medical Informatics. 129, p. 107-113 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Inferring disease-associated long non-coding RNAs using genome - wide tissue expression profiles

Pan, X., Jensen, L. J. & Gorodkin, J., 1 May 2019, In: Bioinformatics. 35, 9, p. 1494-1502 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders

Burgdorf, K. S., Trabjerg, B., Giørtz Pedersen, M., Nissen, J., Banasik, K., Birger Pedersen, O., Sørensen, E., René Nielsen, K., Hørup Larsen, M., Erikstrup, C., Bruun-Rasmussen, P., Westergaard, D., Wegner Thørner, L., Hjalgrim, H., Martina Paarup, H., Brunak, S., Pedersen, C. B., Fuller Torrey, E., Werge, T., Bo Mortensen, P., & 2 othersYolken, R. & Ullum, H., Jul 2019, In: Brain, Behavior, and Immunity. 79, p. 152-158

Research output: Contribution to journal › Journal article › Research › peer-review

44 Citations (Scopus)

195 Downloads (Pure)

Leveraging European infrastructures to access 1 million human genomes by 2022

Saunders, G., Baudis, M., Becker, R., Beltran, S., Béroud, C., Birney, E., Brooksbank, C., Brunak, S., Van den Bulcke, M., Drysdale, R., Capella-Gutierrez, S., Flicek, P., Florindi, F., Goodhand, P., Gut, I., Heringa, J., Holub, P., Hooyberghs, J., Juty, N., Keane, T. M., & 21 othersKorbel, J. O., Lappalainen, I., Leskosek, B., Matthijs, G., Mayrhofer, M. T., Metspalu, A., Navarro, A., Newhouse, S., Nyrönen, T., Page, A., Persson, B., Palotie, A., Parkinson, H., Rambla, J., Salgado, D., Steinfelder, E., Swertz, M. A., Valencia, A., Varma, S., Blomberg, N. & Scollen, S., 1 Nov 2019, In: Nature Reviews. Genetics. 20, p. 693-701 9 p.

Research output: Contribution to journal › Review › peer-review

14 Citations (Scopus)

Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1

Lückmann, M., Trauelsen, M., Bentsen, M. A., Nissen, T. A. D., Martins, J., Fallah, Z., Nygaard, M. M., Papaleo, E., Lindorff-Larsen, K., Schwartz, T. W. & Frimurer, T. M., 2 Apr 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 14, p. 7123-7128

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

12 Downloads (Pure)

New functionalities in the TCGAbiolinks package for the study and integration of cancer data from GDC and GTEx

Mounir, M., Lucchetta, M., Silva, T. C., Olsen, C., Bontempi, G., Chen, X., Noushmehr, H., Colaprico, A. & Papaleo, E., Mar 2019, In: PLOS Computational Biology. 15, 3, 18 p., e1006701.

Research output: Contribution to journal › Journal article › Research › peer-review

62 Citations (Scopus)

9 Downloads (Pure)

Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites

Lundby, A., Franciosa, G., Emdal, K. B., Refsgaard, J. C., Gnosa, S. P., Bekker-Jensen, D. B., Secher, A., Maurya, S. R., Paul, I., Mendez, B. L., Kelstrup, C. D., Francavilla, C., Kveiborg, M., Montoya, G., Jensen, L. J. & Olsen, J. V., 3 Oct 2019, In: Cell. 179, 2, p. 543-560

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

On the hunt for the alternate host of Hemileia vastatrix

Koutouleas, T., Jørgensen, H. J. L., Jensen, B., Lillesø, J-P. B., Junge, A. & Ræbild, A., 1 Dec 2019, In: Ecology and Evolution. 9, 23, p. 13619-13631 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

2 Downloads (Pure)

Patterns of co-occurrence of congenital heart defects follows distinct patterns

Ellesøe, S. G., Workman, C. T., Bouvagnet, P., Loffredo, C. A., McBride, K. L., Hinton, R. B., van Engelen, K., Gertsen, E. C., Mulder, B. J. M., Postma, A. V., Anderson, R. H., Hjortdal, V. E., Brunak, S. & Larsen, L. A., 2019, In: European Journal of Human Genetics. 26, p. 106 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Persons who have never had a headache. Socio-demographic characteristics

Olofsson, I. A., Erikstrup, C., Sørensen, E., Paarup, H. M., Mathiasen, H. P., Hjalmgrim, H., Banasik, K., Nielsen, K. R., Burgdorf, K. S., Pedersen, O. B. V., Ullum, H., Olesen, J. & Hansen, T. F., 2019, In: Cephalalgia. 39, 1, suppl., p. 88-89 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Population-wide analysis of differences in disease progression patterns in men and women

Westergaard, D., Moseley, P., Sørup, F. K. H., Baldi, P. & Brunak, S., 1 Dec 2019, In: Nature Communications. 10, 1, 14 p., 666.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

35 Downloads (Pure)

Predicting treatment response using pharmacy register in migraine

Hansen, T. F., Chalmer, M. A., Haspang, T. M., Kogelman, L. & Olesen, J., 2 Apr 2019, In: The Journal of Headache and Pain. 20, p. 31 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

11 Downloads (Pure)

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Albrecht, W., Kappenberg, F., Brecklinghaus, T., Stoeber, R., Marchan, R., Zhang, M., Ebbert, K., Kirschner, H., Grinberg, M., Leist, M., Moritz, W., Cadenas, C., Ghallab, A., Reinders, J., Vartak, N., van Thriel, C., Golka, K., Tolosa, L., Castell, J. V., Damm, G., & 28 othersSeehofer, D., Lampen, A., Braeuning, A., Buhrke, T., Behr, A-C., Oberemm, A., Gu, X., Kittana, N., van de Water, B., Kreiling, R., Fayyaz, S., van Aerts, L., Smedsrød, B., Ellinger-Ziegelbauer, H., Steger-Hartmann, T., Gundert-Remy, U., Zeigerer, A., Ullrich, A., Runge, D., Lee, S. M. L., Schiergens, T. S., Kuepfer, L., Aguayo-Orozco, A., Sachinidis, A., Edlund, K., Gardner, I., Rahnenführer, J. & Hengstler, J. G., 1 Jun 2019, In: Archives of Toxicology. 93, 6, p. 1609-1637 29 p.

Research output: Contribution to journal › Journal article › Research › peer-review

41 Citations (Scopus)

6 Downloads (Pure)

Prevalence of patients with self‐reported hidradenitis suppurativa in a cohort of Danish blood donors: a cross‐sectional study

Riis, P. T., Pedersen, O. B., Sigsgaard, V., Erikstrup, C., Paarup, H. M., Nielsen, K. R., Burgdorf, K. S., Hjalgrim, H., Rostgaard, K., Banasik, K., Ullum, H. & Jemec, G. B., Apr 2019, In: British Journal of Dermatology. 180, 4, p. 774-781

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

Promoting transparency and reproducibility in enhanced molecular simulations

Bonomi, M., Bussi, G., Camilloni, C., Tribello, G. A., Banas, P., Barducci, A., Bernetti, M., Bolhuis, P. G., Bottaro, S., Branduardi, D., Capelli, R., Carloni, P., Ceriotti, M., Cesari, A., Chen, H., Chen, W., Colizzi, F., De, S., De La Pierre, M., Donadio, D., & 54 othersDrobot, V., Ensing, B., Ferguson, A. L., Filizola, M., Fraser, J. S., Fu, H., Gasparotto, P., Gervasio, F. L., Giberti, F., Gil-Ley, A., Giorgino, T., Heller, G. T., Hocky, G. M., Iannuzzi, M., Invernizzi, M., Jelfs, K. E., Jussupow, A., Kirilin, E., Laio, A., Limongelli, V., Lindorff-Larsen, K., Lohr, T., Marinelli, F., Martin-Samos, L., Masetti, M., Meyer, R., Michaelides, A., Molteni, C., Morishita, T., Nava, M., Paissoni, C., Papaleo, E., Parrinello, M., Pfaendtner, J., Piaggi, P., Piccini, G., Pietropaolo, A., Pietrucci, F., Pipolo, S., Provasi, D., Quigley, D., Raiteri, P., Raniolo, S., Rydzewski, J., Salvalaglio, M., Sosso, G. C., Spiwok, V., Sponer, J., Swenson, D. W. H., Tiwary, P., Valsson, O., Vendruscolo, M., Voth, G. A. & White, A., 1 Aug 2019, In: Nature Methods. 16, 8, p. 670-673

Research output: Contribution to journal › Editorial › peer-review

116 Citations (Scopus)

Disease Systems Biology Program

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