Leveraging European infrastructures to access 1 million human genomes by 2022

Gary Saunders; Michael Baudis; Regina Becker; Sergi Beltran; Christophe Béroud; Ewan Birney; Cath Brooksbank; Søren Brunak; Marc Van den Bulcke; Rachel Drysdale; Salvador Capella-Gutierrez; Paul Flicek; Francesco Florindi; Peter Goodhand; Ivo Gut; Jaap Heringa; Petr Holub; Jef Hooyberghs; Nick Juty; Thomas M Keane; Jan O Korbel; Ilkka Lappalainen; Brane Leskosek; Gert Matthijs; Michaela Th Mayrhofer; Andres Metspalu; Arcadi Navarro; Steven Newhouse; Tommi Nyrönen; Angela Page; Bengt Persson; Aarno Palotie; Helen Parkinson; Jordi Rambla; David Salgado; Erik Steinfelder; Morris A Swertz; Alfonso Valencia; Susheel Varma; Niklas Blomberg; Serena Scollen

doi:10.1038/s41576-019-0156-9

Leveraging European infrastructures to access 1 million human genomes by 2022

Gary Saunders, Michael Baudis, Regina Becker, Sergi Beltran, Christophe Béroud, Ewan Birney, Cath Brooksbank, Søren Brunak, Marc Van den Bulcke, Rachel Drysdale, Salvador Capella-Gutierrez, Paul Flicek, Francesco Florindi, Peter Goodhand, Ivo Gut, Jaap Heringa, Petr Holub, Jef Hooyberghs, Nick Juty, Thomas M KeaneJan O Korbel, Ilkka Lappalainen, Brane Leskosek, Gert Matthijs, Michaela Th Mayrhofer, Andres Metspalu, Arcadi Navarro, Steven Newhouse, Tommi Nyrönen, Angela Page, Bengt Persson, Aarno Palotie, Helen Parkinson, Jordi Rambla, David Salgado, Erik Steinfelder, Morris A Swertz, Alfonso Valencia, Susheel Varma, Niklas Blomberg, Serena Scollen

Disease Systems Biology Program

14 Citations (Scopus)

Abstract

Human genomics is undergoing a step change from being a predominantly research-driven activity to one driven through health care as many countries in Europe now have nascent precision medicine programmes. To maximize the value of the genomic data generated, these data will need to be shared between institutions and across countries. In recognition of this challenge, 21 European countries recently signed a declaration to transnationally share data on at least 1 million human genomes by 2022. In this Roadmap, we identify the challenges of data sharing across borders and demonstrate that European research infrastructures are well-positioned to support the rapid implementation of widespread genomic data access.

Original language	English
Journal	Nature Reviews. Genetics
Volume	20
Pages (from-to)	693-701
Number of pages	9
ISSN	1471-0056
DOIs	https://doi.org/10.1038/s41576-019-0156-9
Publication status	Published - 1 Nov 2019

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Saunders, G., Baudis, M., Becker, R., Beltran, S., Béroud, C., Birney, E., Brooksbank, C., Brunak, S., Van den Bulcke, M., Drysdale, R., Capella-Gutierrez, S., Flicek, P., Florindi, F., Goodhand, P., Gut, I., Heringa, J., Holub, P., Hooyberghs, J., Juty, N., ... Scollen, S. (2019). Leveraging European infrastructures to access 1 million human genomes by 2022. Nature Reviews. Genetics, 20, 693-701. https://doi.org/10.1038/s41576-019-0156-9

Saunders, G, Baudis, M, Becker, R, Beltran, S, Béroud, C, Birney, E, Brooksbank, C, Brunak, S, Van den Bulcke, M, Drysdale, R, Capella-Gutierrez, S, Flicek, P, Florindi, F, Goodhand, P, Gut, I, Heringa, J, Holub, P, Hooyberghs, J, Juty, N, Keane, TM, Korbel, JO, Lappalainen, I, Leskosek, B, Matthijs, G, Mayrhofer, MT, Metspalu, A, Navarro, A, Newhouse, S, Nyrönen, T, Page, A, Persson, B, Palotie, A, Parkinson, H, Rambla, J, Salgado, D, Steinfelder, E, Swertz, MA, Valencia, A, Varma, S, Blomberg, N & Scollen, S 2019, 'Leveraging European infrastructures to access 1 million human genomes by 2022', Nature Reviews. Genetics, vol. 20, pp. 693-701. https://doi.org/10.1038/s41576-019-0156-9

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AU - Holub, Petr

AU - Hooyberghs, Jef

AU - Juty, Nick

AU - Keane, Thomas M

AU - Korbel, Jan O

AU - Lappalainen, Ilkka

AU - Leskosek, Brane

AU - Matthijs, Gert

AU - Mayrhofer, Michaela Th

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AU - Navarro, Arcadi

AU - Newhouse, Steven

AU - Nyrönen, Tommi

AU - Page, Angela

AU - Persson, Bengt

AU - Palotie, Aarno

AU - Parkinson, Helen

AU - Rambla, Jordi

AU - Salgado, David

AU - Steinfelder, Erik

AU - Swertz, Morris A

AU - Valencia, Alfonso

AU - Varma, Susheel

AU - Blomberg, Niklas

AU - Scollen, Serena

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Leveraging European infrastructures to access 1 million human genomes by 2022

Abstract

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