Kristina Bennet Emdal

Phone+4535336420
Emailkristina.emdalcpr.kudk
Websitehttp://www.cpr.ku.dk

Blegdamsvej 3B
2200 København N

Research activity per year

Short presentation

Kristina Bennet Emdal's research is focused on using quantitative mass spectrometry to study cell signaling in cancer biology.

Understanding TrkA and ALK receptor signaling in neuroblastoma cells
Identification of disease-state biomarkers in patient-derived kidney samples
Identification of drug-response signatures in acute myeloid leukemia patient samples

Primary fields of research

• Receptor tyrosine kinase signaling
• Phosphoproteomics
• Cancer biology

CV

2018 –
Postdoc, Olsen Group, Department of Proteomics, NNF Center for Protein Research, University of Copenhagen, Denmark

2015 – 2018
Postdoc Associate, White Lab, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA

2011 – 2015
PhD student, Olsen Group, Department of Proteomics, NNF Center for Protein Research, University of Copenhagen, Denmark

2008 – 2011
Research Assistant, Department of Breast Cancer Research, Danish Cancer Society, Copenhagen, Denmark

2008
M.Sc. Human Biology, University of Copenhagen, Denmark

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

Keywords

Faculty of Health and Medical Sciences
Phosphoproteomics
Mass Spectrometry
Cancer Biology
Cell Signaling

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11 Journal article
1 Comment/debate

Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues
Emdal, K. B. & Lundby, A., 2 Jan 2020, In: Molecular & Cellular Oncology. 3 p., e1692643.
Research output: Contribution to journal › Comment/debate › Research › peer-review
Dynamic lineage priming is driven via direct enhancer regulation by ERK
Hamilton, W. B., Mosesson, Y., Monteiro, R. S., Emdal, K. B., Knudsen, T. E., Francavilla, C., Barkai, N., Olsen, J. V. & Brickman, J. M., 14 Nov 2019, In: Nature. 575, p. 355-360
Research output: Contribution to journal › Journal article › Research › peer-review
17 Citations (Scopus)
Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
Lundby, A., Franciosa, G., Emdal, K. B., Refsgaard, J. C., Gnosa, S. P., Bekker-Jensen, D. B., Secher, A., Maurya, S. R., Paul, I., Mendez, B. L., Kelstrup, C. D., Francavilla, C., Kveiborg, M., Montoya, G., Jensen, L. J. & Olsen, J. V., 3 Oct 2019, In: Cell. 179, 2, p. 543-560
Research output: Contribution to journal › Journal article › Research › peer-review
14 Citations (Scopus)
Identifying and targeting sporadic oncogenic genetic aberrations in mouse models of triple-negative breast cancer
Liu, H., Murphy, C. J., Karreth, F. A., Emdal, K. B., Yang, K., White, F. M., Elemento, O., Toker, A., Wulf, G. M. & Cantley, L. C., 2018, In: Cancer Discovery. 8, 3, p. 354-369 16 p.
Research output: Contribution to journal › Journal article › Research › peer-review
28 Citations (Scopus)
Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma
Randall, E. C., Emdal, K. B., Laramy, J. K., Kim, M., Roos, A., Calligaris, D., Regan, M. S., Gupta, S. K., Mladek, A. C., Carlson, B. L., Johnson, A. J., Lu, F-K., Xie, X. S., Joughin, B. A., Reddy, R. J., Peng, S., Abdelmoula, W. M., Jackson, P. R., Kolluri, A., Kellersberger, K. A., & 8 othersAgar, J. N., Lauffenburger, D. A., Swanson, K. R., Tran, N. L., Elmquist, W. F., White, F. M., Sarkaria, J. N. & Agar, N. Y. R., 1 Dec 2018, In: Nature Communications. 9, 1, p. 4904
Research output: Contribution to journal › Journal article › Research › peer-review
26 Citations (Scopus)
Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma
Emdal, K. B., Pedersen, A-K., Bekker-Jensen, D. B., Lundby, A., Claeys, S., De Preter, K., Speleman, F., Francavilla, C. & Olsen, J. V., 20 Nov 2018, In: Science Signaling. 11, 557, p. 1-17 17 p., eaap9752.
Research output: Contribution to journal › Journal article › Research › peer-review
9 Citations (Scopus)
Characterization of in vivo resistance to osimertinib and JNJ-61186372, an EGFR/Met bispecific antibody, reveals unique and consensus mechanisms of resistance
Emdal, K. B., Dittmann, A., Reddy, R. J., Lescarbeau, R. S., Moores, S. L., Laquerre, S. & White, F. M., 1 Nov 2017, In: Molecular Cancer Therapeutics. 16, 11, p. 2572-2585 14 p.
Research output: Contribution to journal › Journal article › Research › peer-review
10 Citations (Scopus)
Combinatorial Drug Screening Identifies Ewing Sarcoma–specific Sensitivities
Radic-Sarikas, B., Tsafou, K. P., Emdal, K. B., Papamarkou, T., Huber, K. V. M., Mutz, C., Toretsky, J. A., Bennett, K. L., Olsen, J. V., Brunak, S., Kovar, H. & Superti-Furga, G., 1 Jan 2017, In: Molecular Cancer Therapeutics. 16, 1, p. 88-101 14 p.
Research output: Contribution to journal › Journal article › Research › peer-review
11 Citations (Scopus)