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Thomas Werge

  • Nordre Ringvej 26-67, 2600 Glostrup

20022021

Research activity per year

Personal profile

Short presentation

My research has focused on explaining the biological reasons that contributes to the development of severe mental disorders such as schizophrenia and autism - disorders, that all have great personal and social costs. In the future this knowledge provides us with the tools to diagnose patients on a patient specific level. Further it provides the basis for a personalized drug development. These can have a more directly effect on the diagnosed disease and less side effects compared to current drugs used in treatment of mental disorders. During my research I have taken initiative to create the Danish Psychiatric Biobank, which aims to identify the genetic constellations of mental disorders. Together with other international research groups I have identified changes in the genome that for some carriers can be associated with the development of severe mental disorders. On a daily basis I am PI and Co-PI on several projects that all have the purpose to obtain a thorough explanation of the biological causes of mental disorders. Such kind of work requires a broad interdisciplinary collaboration where the disorders are examined on multiple levels; from genes and cells to population cohorts, and from fetal life to the patient.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Keywords

  • Faculty of Health and Medical Sciences
  • Mental illness
  • Genetics
  • Mutations
  • Personalized drug development
  • Diagnosis
  • Schizophrenia
  • ADHD
  • Autism
  • Bipolar
  • Depression
  • Etiology
  • Genetic and environmental risk factors
  • Co-morbidity
  • Animal models

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Collaborations and top research areas from the last five years

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  • A polygenic resilience score moderates the genetic risk for schizophrenia

    Hess, J. L., Tylee, D. S., Mattheisen, M., Børglum, A. D., Als, T. D., Grove, J., Werge, T., Mortensen, P. B., Mors, O., Nordentoft, M., Hougaard, D. M., Byberg-grauholm, J., Bækvad-hansen, M., Greenwood, T. A., Tsuang, M. T., Curtis, D., Steinberg, S., Sigurdsson, E., Stefánsson, H. & Stefánsson, K. & 4 others, Edenberg, H. J., Holmans, P., Faraone, S. V. & Glatt, S. J., 1 Mar 2021, In: Molecular Psychiatry. 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

    6 Citations (Scopus)

  • Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

    Forstner, A. J., Awasthi, S., Wolf, C., Maron, E., Erhardt, A., Czamara, D., Eriksson, E., Lavebratt, C., Allgulander, C., Friedrich, N., Becker, J., Hecker, J., Rambau, S., Conrad, R., Geiser, F., Mcmahon, F. J., Moebus, S., Hess, T., Buerfent, B. C. & Hoffmann, P. & 55 others, Herms, S., Heilmann-heimbach, S., Kockum, I., Olsson, T., Alfredsson, L., Weber, H., Alpers, G. W., Arolt, V., Fehm, L., Fydrich, T., Gerlach, A. L., Hamm, A., Kircher, T., Pané-farré, C. A., Pauli, P., Rief, W., Ströhle, A., Plag, J., Lang, T., Wittchen, H.-U., Mattheisen, M., Meier, S., Metspalu, A., Domschke, K., Reif, A., Hovatta, I., Lindefors, N., Andersson, E., Schalling, M., Mbarek, H., Milaneschi, Y., De Geus, E. J. C., Boomsma, D. I., Penninx, B. W. J. H., Thorgeirsson, T. E., Steinberg, S., Stefansson, K., Stefansson, H., Müller-myhsok, B., Hansen, T. F., Børglum, A. D., Werge, T., Mortensen, P. B., Nordentoft, M., Hougaard, D. M., Hultman, C. M., Sullivan, P. F., Nöthen, M. M., Woldbye, D. P. D., Mors, O., Binder, E. B., Rück, C., Ripke, S., Deckert, J. & Schumacher, J., Aug 2021, In: Molecular Psychiatry. 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

    4 Citations (Scopus)

  • Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study

    Erlangsen, A., Appadurai, V., Wang, Y., Turecki, G., Mors, O., Werge, T., Mortensen, P. B., Starnawska, A., Børglum, A. D., Schork, A., Nudel, R., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hougaard, D. M., Thompson, W. K., Nordentoft, M. & Agerbo, E., 1 Oct 2020, In: Molecular Psychiatry.

    Research output: Contribution to journal › Journal article › Research › peer-review

    29 Citations (Scopus)

  • Language deficits in specific language impairment, attention deficit/hyperactivity disorder, and autism spectrum disorder: An analysis of polygenic risk

    Nudel, R., Christiani, C. A. J., Ohland, J., Uddin, M. J., Hemager, N., Ellersgaard, D. V., Spang, K. S., Burton, B. K., Greve, A. N., Gantriis, D. L., Bybjerg-Grauholm, J., Jepsen, J. R. M., Thorup, A. A. E., Mors, O., Nordentoft, M. & Werge, T., 1 Mar 2020, In: Autism Research.

    Research output: Contribution to journal › Journal article › Research › peer-review

    2 Citations (Scopus)

  • A large-scale genomic investigation of susceptibility to infection and its association with mental disorders in the Danish population

    Nudel, R., Wang, Y., Appadurai, V., Schork, A. J., Buil, A., Agerbo, E., Bybjerg-Grauholm, J., Børglum, A. D., Daly, M. J., Mors, O., Hougaard, D. M., Mortensen, P. B., Werge, T., Nordentoft, M., Thompson, W. K. & Benros, M. E., 1 Dec 2019, In: Translational Psychiatry. 9, 1, 10 p., 283.

    Research output: Contribution to journal › Journal article › Research › peer-review

    7 Citations (Scopus)

  • Association of Childhood Exposure to Nitrogen Dioxide and Polygenic Risk Score for Schizophrenia With the Risk of Developing Schizophrenia

    Horsdal, H. T., Agerbo, E., McGrath, J. J., Vilhjálmsson, B. J., Antonsen, S., Closter, A. M., Timmermann, A., Grove, J., Mok, P. L. H., Webb, R. T., Sabel, C. E., Hertel, O., Sigsgaard, T., Erikstrup, C., Hougaard, D. M., Werge, T., Nordentoft, M., Børglum, A. D., Mors, O. & Mortensen, P. B. & 3 others, Brandt, J., Geels, C. & Pedersen, C. B., 11 Nov 2019, In: JAMA network open. 2, 11, e1914401.

    Research output: Contribution to journal › Journal article › Research › peer-review

    9 Citations (Scopus)

  • Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia with Risk for Depression in the Danish Population

    Musliner, K. L., Mortensen, P. B., McGrath, J. J., Suppli, N. P., Hougaard, D. M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Andreassen, O., Pedersen, C. B., Pedersen, M. G., Mors, O., Nordentoft, M., Børglum, A. D., Werge, T. & Agerbo, E., 2019, In: JAMA Psychiatry. 76, 5, p. 516-525 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

    30 Citations (Scopus)

  • Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

    Barbu, M. C., Zeng, Y., Shen, X., Cox, S. R., Clarke, T.-K., Gibson, J., Adams, M. J., Johnstone, M., Haley, C. S., Lawrie, S. M., Deary, I. J., Mcintosh, A. M., Whalley, H. C., Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A. & Adams, M. J. & 216 others, Agerbo, E., Air, T. M., Andlauer, T. F. M., Bacanu, S.-A., Bækvad-hansen, M., Beekman, A. T. F., Bigdeli, T. B., Binder, E. B., Blackwood, D. H. R., Bryois, J., Buttenschøn, H. N., Bybjerg-grauholm, J., Cai, N., Castelao, E., Christensen, J. H., Clarke, T.-K., Coleman, J. R. I., Colodro-conde, L., Couvy-duchesne, B., Craddock, N., Crawford, G. E., Davies, G., Deary, I. J., Degenhardt, F., Derks, E. M., Direk, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Escott-price, V., Hassan Kiadeh, F. F., Finucane, H. K., Forstner, A. J., Frank, J., Gaspar, H. A., Gill, M., Goes, F. S., Gordon, S. D., Grove, J., Hall, L. S., Hansen, C. S., Hansen, T. F., Herms, S., Hickie, I. B., Hoffmann, P., Homuth, G., Horn, C., Hottenga, J.-J., Hougaard, D. M., Ising, M., Jansen, R., Jorgenson, E., Knowles, J. A., Kohane, I. S., Kraft, J., Kretzschmar, W. W., Krogh, J., Kutalik, Z., Li, Y., Lind, P. A., Macintyre, D. J., Mackinnon, D. F., Maier, R. M., Maier, W., Marchini, J., Mbarek, H., Mcgrath, P., Mcguffin, P., Medland, S. E., Mehta, D., Middeldorp, C. M., Mihailov, E., Milaneschi, Y., Milani, L., Mondimore, F. M., Montgomery, G. W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nivard, M. G., Nyholt, D. R., O'reilly, P. F., Oskarsson, H., Owen, M. J., Painter, J. N., Pedersen, C. B., Pedersen, M. G., Peterson, R. E., Pettersson, E., Peyrot, W. J., Pistis, G., Posthuma, D., Quiroz, J. A., Qvist, P., Rice, J. P., Riley, B. P., Rivera, M., Mirza, S. S., Schoevers, R., Schulte, E. C., Shen, L., Shi, J., Shyn, S. I., Sigurdsson, E., Sinnamon, G. C. B., Smit, J. H., Smith, D. J., Stefansson, H., Steinberg, S., Streit, F., Strohmaier, J., Tansey, K. E., Teismann, H., Teumer, A., Thompson, W., Thomson, P. A., Thorgeirsson, T. E., Traylor, M., Treutlein, J., Trubetskoy, V., Uitterlinden, A. G., Umbricht, D., Van Der Auwera, S., Van Hemert, A. M., Viktorin, A., Visscher, P. M., Wang, Y., Webb, B. T., Weinsheimer, S. M., Wellmann, J., Willemsen, G., Witt, S. H., Wu, Y., Xi, H. S., Yang, J., Zhang, F., Arolt, V., Baune, B. T., Berger, K., Boomsma, D. I., Cichon, S., Dannlowski, U., De Geus, E. J. C., Depaulo, J. R., Domenici, E., Domschke, K., Esko, T., Grabe, H. J., Hamilton, S. P., Hayward, C., Heath, A. C., Kendler, K. S., Kloiber, S., Lewis, G., Li, Q. S., Lucae, S., Madden, P. A. F., Magnusson, P. K., Martin, N. G., Mcintosh, A. M., Metspalu, A., Mors, O., Mortensen, P. B., Müller-myhsok, B., Nordentoft, M., Nöthen, M. M., O'donovan, M. C., Paciga, S. A., Pedersen, N. L., Penninx, B. W. J. H., Perlis, R. H., Porteous, D. J., Potash, J. B., Preisig, M., Rietschel, M., Schaefer, C., Schulze, T. G., Smoller, J. W., Stefansson, K., Tiemeier, H., Uher, R., Völzke, H., Weissman, M. M., Werge, T., Lewis, C. M., Levinson, D. F., Breen, G., Børglum, A. D., Sullivan, P. F., Agee, M., Alipanahi, B., Auton, A., Bell, R. K., Bryc, K., Elson, S. L., Fontanillas, P., Furlotte, N. A., Hinds, D. A., Huber, K. E., Kleinman, A., Litterman, N. K., Mccreight, J. C., Mcintyre, M. H., Mountain, J. L., Noblin, E. S., Northover, C. A. M., Pitts, S. J., Sathirapongsasuti, J. F., Sazonova, O. V., Shelton, J. F., Shringarpure, S., Tian, C., Tung, J. Y., Vacic, V. & Wilson, C. H., Jan 2019, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

    9 Citations (Scopus)
    31 Downloads (Pure)
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