Brian Tate Weinert

Research activity per year

Primary fields of research

Analysis of proteins and protein posttranslational modifications by quantitative mass spectrometry with a focus on acetylation and other acylations.

Current research

Proteome-wide analysis of acetylation dynamics in organisms ranging from bacteria to mice and human cells.

Teaching

• Proteomics course at the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
• Molecular Mechanisms of Aging and Molecular Immunology at the University of California, Berkeley
• Recipient of an Outstanding Graduate Student Instructor award for creating and teaching an undergraduate seminar course

Fields of interest

• Proteomics
• Mass spectrometry
• Posttranslational modifications, aging and lifespan
• DNA repair and recombination, and bioinformatics/data analysis

Keywords

Faculty of Health and Medical Sciences
Mass spectrometry
Proteomics
Posttranslational modification
Acetylation
Phosphorylation
Ubiquitylation

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6 Similar Profiles

21 Journal article
3 Review
2 Comment/debate

Acetylation of intrinsically disordered regions regulates phase separation
Saito, M., Hess, D., Eglinger, J., Fritsch, A. W., Kreysing, M., Weinert, B. T., Choudhary, C. & Matthias, P., Jan 2019, In: Nature Chemical Biology. 15, 1, p. 51-61
Research output: Contribution to journal › Journal article › Research › peer-review
60 Citations (Scopus)
Analysis and Interpretation of Protein Post-Translational Modification Site Stoichiometry
Prus, G., Hoegl, A., Weinert, B. T. & Choudhary, C., Nov 2019, In: Trends in Biochemical Sciences. 44, 11, p. 943-960
Research output: Contribution to journal › Review › peer-review
13 Citations (Scopus)
Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
Hansen, B. K., Gupta, R., Baldus, L., Lyon, D., Narita, T., Lammers, M., Choudhary, C. & Weinert, B. T., 1 Dec 2019, In: Nature Communications. 10, 11 p., 1055.
Research output: Contribution to journal › Journal article › Research › peer-review
36 Citations (Scopus)

31 Downloads (Pure)
Functions and mechanisms of non-histone protein acetylation
Narita, T., Weinert, B. T. & Choudhary, C., 1 Mar 2019, In: Nature Reviews. Molecular Cell Biology. 20, p. 156-174 19 p.
Research output: Contribution to journal › Review › peer-review
175 Citations (Scopus)
Retraction
Kaidi, A., Weinert, B. T., Choudhary, C. & Jackson, S. P., 19 Apr 2019, In: Science. 364, 6437, p. 247 1 p.
Research output: Contribution to journal › Comment/debate › Research
Benchmarking common quantification strategies for large-scale phosphoproteomics
Hogrebe, A., von Stechow, L., Bekker-Jensen, D. B., Weinert, B. T., Kelstrup, C. D. & Olsen, J. V., 2018, In: Nature Communications. 9, 1, p. 1-13 1045.
Research output: Contribution to journal › Journal article › Research › peer-review
101 Citations (Scopus)

87 Downloads (Pure)
Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome
Weinert, B. T., Narita, T., Satpathy, S., Srinivasan, B., Hansen, B. K., Schölz, C., Hamilton, W. B., Zucconi, B. E., Wang, W. W., Liu, W. R., Brickman, J. M., Kesicki, E. A., Lai, A., Bromberg, K. D., Cole, P. A. & Choudhary, C., 2018, In: Cell. 174, 1, p. 231-244.e12 27 p.
Research output: Contribution to journal › Journal article › Research › peer-review
91 Citations (Scopus)
Accurate quantification of site-specific acetylation stoichiometry reveals the impact of sirtuin deacetylase CobB on the E. coli acetylome
Weinert, B. T., Satpathy, S., Hansen, B. K., Lyon, D., Jensen, L. J. & Choudhary, C. R., May 2017, In: Molecular and Cellular Proteomics. 16, p. 759-769
Research output: Contribution to journal › Journal article › Research › peer-review
35 Citations (Scopus)