TY - JOUR
T1 - DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors
AU - Hansen, Thomas Folkmann
AU - Banasik, Karina
AU - Erikstrup, Christian
AU - Pedersen, Ole Birger
AU - Westergaard, David
AU - Chmura, Piotr Jaroslaw
AU - Nielsen, Kaspar
AU - Thørner, Lise
AU - Hjalgrim, Henrik
AU - Paarup, Helene
AU - Larsen, Margit Anita Hørup
AU - Petersen, Mikkel
AU - Jennum, Poul
AU - Andersen, Steffen
AU - Nyegaard, Mette
AU - Jemec, Gregor Borut Ernst
AU - Olesen, Jes
AU - Werge, Thomas
AU - Johansson, Pär I
AU - Sørensen, Erik
AU - Brunak, Søren
AU - Ullum, Henrik
AU - Burgdorf, Kristoffer Sølvsten
N1 - © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - PURPOSE: To establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.PARTICIPANTS: Blood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.FINDINGS TO DATE: The cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.FUTURE PLANS: To provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors.
AB - PURPOSE: To establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.PARTICIPANTS: Blood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.FINDINGS TO DATE: The cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.FUTURE PLANS: To provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors.
U2 - 10.1136/bmjopen-2018-028401
DO - 10.1136/bmjopen-2018-028401
M3 - Journal article
C2 - 31182452
SN - 2044-6055
VL - 9
SP - 1
EP - 7
JO - BMJ Open
JF - BMJ Open
IS - 6
M1 - e028401
ER -
