Research output per year
Research output per year
Personal profile
Short presentation
Elena Papaleo is Associate Professor on a split position between the University of Copenhagen and Kraeftens Bekaempelse (where she is group leader of the Computational Biology Laboratory). Her research interest focuses on the use of computational methods integrated by experimental data in cancer research. In particular, her group aim: i) to identify new specific markers for different cancer types, ii) assess the functional and structural impact of germline and somatic missense mutations and their interplay with post-translational modifications, and iii) to characterize new possible therapeutic targets. Elena also acts as a section or academic editor for different open access journals, such as PeerJ, PLoS Computational Biology, PLoS ONE and Frontiers in Molecular Biosciences.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Kræftens Bekæmpelse
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Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome
Abildgaard, A. B., Stein, A., Nielsen, S. V., Schultz-Knudsen, K., Papaleo, E., Shrikhande, A., Hoffmann, E. R., Bernstein, I., Gerdes, A-M., Takahashi, M., Ishioka, C., Lindorff-Larsen, K. & Hartmann-Petersen, R., Nov 2019, In: eLife. 8, 28 p., e49138 .Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct signatures of lung cancer types: aberrant mucin O-glycosylation and compromised immune response
Lucchetta, M., da Piedade, I., Mounir, M., Vabistsevits, M., Terkelsen, T. & Papaleo, E., 20 Aug 2019, In: BMC Cancer. 19, 824.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
Lückmann, M., Trauelsen, M., Bentsen, M. A., Nissen, T. A. D., Martins, J., Fallah, Z., Nygaard, M. M., Papaleo, E., Lindorff-Larsen, K., Schwartz, T. W. & Frimurer, T. M., 2 Apr 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 14, p. 7123-7128Research output: Contribution to journal › Journal article › Research › peer-review
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New functionalities in the TCGAbiolinks package for the study and integration of cancer data from GDC and GTEx
Mounir, M., Lucchetta, M., Silva, T. C., Olsen, C., Bontempi, G., Chen, X., Noushmehr, H., Colaprico, A. & Papaleo, E., Mar 2019, In: PLOS Computational Biology. 15, 3, 18 p., e1006701.Research output: Contribution to journal › Journal article › Research › peer-review
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Promoting transparency and reproducibility in enhanced molecular simulations
Bonomi, M., Bussi, G., Camilloni, C., Tribello, G. A., Banas, P., Barducci, A., Bernetti, M., Bolhuis, P. G., Bottaro, S., Branduardi, D., Capelli, R., Carloni, P., Ceriotti, M., Cesari, A., Chen, H., Chen, W., Colizzi, F., De, S., De La Pierre, M., Donadio, D., & 54 others, 1 Aug 2019, In: Nature Methods. 16, 8, p. 670-673Research output: Contribution to journal › Editorial › peer-review
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Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion
Brix, D. M., Tvingsholm, S. A., Hansen, M. B., Clemmensen, K. B., Ohman, T., Siino, V., Lambrughi, M., Hansen, K., Puustinen, P., Gromova, I., James, P., Papaleo, E., Varjosalo, M., Moreira, J., Jäättelä, M. & Kallunki, T., 25 Apr 2019, In: Oncogene. 38, p. 3170-3184Research output: Contribution to journal › Journal article › Research › peer-review
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Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites
Holdgaard, S. G., Cianfanelli, V., Pupo, E., Lambrughi, M., Lubas, M., Nielsen, J. C., Eibes, S., Maiani, E., Harder, L. M., Wesch, N., Foged, M. M., Maeda, K., Nazio, F., de la Ballina, L. R., Dötsch, V., Brech, A., Frankel, L. B., Jäättelä, M., Locatelli, F., Barisic, M., & 8 others, 1 Dec 2019, In: Nature Communications. 10, 1, p. 1-19 19 p., 4176.Research output: Contribution to journal › Journal article › Research › peer-review
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Use of Computational Biochemistry for Elucidating Molecular Mechanisms of Nitric Oxide Synthase
Bignon, E., Rizza, S., Filomeni, G. & Papaleo, E., 2019, In: Computational and Structural Biotechnology Journal. 17, p. 415-429 15 p.Research output: Contribution to journal › Review › peer-review