Niels Grarup

Research activity per year

Current research

Type 2 diabetes is a disorder caused by a subtle combination of heritable factors and environmental and lifestyle risk factors. Also intermediary diabetes-related physiological traits such as obesity, insulin resistance and disturbed insulin secretion have been shown to be partly modulated by genetic factors. My research interests are focused on identification genetic variation associated with type 2 diabetes (diabetes genomics discovery) and on performing detailed physiological characterization of these variants in relation to diabetes phenotype (genetic-epidemiology and genetic-physiology studies). Genetic variation is explored by both next generation nucleotide sequencing and by large-scale genotyping array-based genotyping. The long term goals are to gain a deeper understanding of the genetic architecture of type 2 diabetes, to expand our insights into diabetes pathogenesis and pathophysiology and possibly thereby derive novel drug targets for diabetes and in the longer term cause advances in clinical diabetes management and prevention.

CV

Education

2003 MD, University of Copenhagen

2009 PhD, Aarhus University (Title: Genetic aspects of type 2 diabetes and related traits – The past, present and future)

Previous positions

1999-2000 Research assistant at Steno Diabetes Center

2003-2005 Resident at Department of Endocrinology, Herlev University Hospital Department of Orthopedic Surgery and Department and internal medicine at Storstrømmens Sygehus Nykøbing Falster and at General Practitioner Christian Schlütter, Nykøbing Falster

2005-2009 PhD-student at Steno Diabetes Center, Copenhagen enrolled at Aarhus University

2009-2010 Post.doc at Hagedorn Research Institute, Gentofte

2010-2012 Post.doc at University of Copenhagen

Educational activities and lecturing experience

Supervised five graduate students

Pre- and postgraduate teacher at University of Copenhagen, Aarhus University and University of Southern Denmark

Teacher at Steno Diabetes Center, STAR Education Programme

Multiple oral and poster presentations at international scientific meetings and several invited lectures

Awards

Winner of Lecture Competition at the annual meeting of the Danish Society for Internal Medicine (2007), Award for basic research at the annual meeting of the Danish Society of Endocrinology (2008), Bagger-Sørensen Foundation Talent Award (2010), Schwartz-Sørensen Award (2011)

Other scientific activities

Reviewer for Diabetes, Diabetologia, Clinical Endocrinology, Obesity, PLoS One among others

Board member of the Scandinavian Society for the Study of Diabetes (SSSD) and organizer of the 47^th Annual Meeting of SSSD in 2012.

Work package leader and member of Consultative Council of Danish Diabetes Academy

Software skills

Microsoft Office, SPSS, R, PLINK, METAL, EPACTS and various web-based genetics tools.

Publications

Pubmed: http://www.ncbi.nlm.nih.gov/pubmed?term=grarup-n[au]

58 peer-reviewed original papers

2 peer-reviewed reviews

2 textbook chapters

H-index: 19

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

Keywords

Faculty of Health and Medical Sciences
genetic epidemiology
type 2 diabetes
metabolism
physiology
next generation sequencing
genome-wide association studies

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8 Similar Profiles

179 Journal article
4 Letter
3 Review
1 Conference abstract in journal
More
- 1 Conference article

Abdominal adiposity and cardiometabolic risk factors in children and adolescents: A Mendelian randomization analysis
Viitasalo, A., Schnurr, T. M., Pitkänen, N., Hollensted, M., Nielsen, T. R. H., Pahkala, K., Atalay, M., Lind, M. V., Heikkinen, S., Frithioff-Bøjsøe, C., Fonvig, C. E., Grarup, N., Kähönen, M., Carrasquilla, G. D., Larnkjær, A., Pedersen, O., Michaelsen, K. F., Lakka, T. A., Holm, J-C., Lehtimäki, T., & 3 othersRaitakari, O., Hansen, T. & Kilpeläinen, T. O., 1 Nov 2019, In: American Journal of Clinical Nutrition. 110, 5, p. 1079-1087 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
8 Citations (Scopus)
ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations
Graae, A-S., Grarup, N., Ribel-Madsen, R., Lystbæk, S. H., Boesgaard, T., Staiger, H., Fritsche, A., Wellner, N., Sulek, K., Kjølby, M. F., Backe, M. B., Chubanava, S., Prats, C., Serup, A. K. L., Birk, J. B., Dubail, J., Gillberg, L., Vienberg, S. G., Nykjær, A., Kiens, B., & 10 othersWojtaszewski, J., Larsen, S., Apte, S. S., Häring, H-U., Vaag, A., Zethelius, B., Pedersen, O. B., Treebak, J. T., Hansen, T. & Holst, B., 1 Mar 2019, In: Diabetes. 68, 3, p. 502-514
Research output: Contribution to journal › Journal article › Research › peer-review
8 Citations (Scopus)
A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria
Ahluwalia, T. S., Schulz, C-A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P-H., Hadjadj, S., Tregouet, D-A., Jorgensen, M. E., Grarup, N., & 9 othersPedersen, O., Simons, M., Groop, L., Orho-Melander, M., McCarthy, M. I., Melander, O., Rossing, P., Kilpelainen, T. O. & Hansen, T., 1 Feb 2019, In: Diabetologia. 62, 2, p. 292-305
Research output: Contribution to journal › Journal article › Research › peer-review
12 Citations (Scopus)

19 Downloads (Pure)
Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis
Skaaby, T., Kilpeläinen, T. O., Taylor, A. E., Mahendran, Y., Wong, A., Ahluwalia, T. S., Paternoster, L., Trompet, S., Stott, D. J., Flexeder, C., Zhou, A., Brusselle, G., Sajjad, A., Lahousse, L., Tiemeier, H., Have, C. T., Thuesen, B. H., Kårhus, L. L., Møllehave, L. T., Leth-Møller, K. B., & 27 othersShabanzadeh, D. M., Gonzalez-Quintela, A., Power, C., Hyppönen, E., Kuh, D., Hardy, R., Meitinger, T., Jukema, J. W., Völker, U., Nauck, M., Völzke, H., Friedrich, N., Bonten, T. N., Noordam, R., Mook-Kanamori, D. O., Tolstrup, J. S., Taube, C., Peters, A., Grallert, H., Strauch, K., Schulz, H., Grarup, N., Hansen, T., Pedersen, O., Burgess, S., Munafò, M. R. & Linneberg, A., 1 Feb 2019, In: Addiction. 114, 2, p. 216-225 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
4 Citations (Scopus)
Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations
Andersson, C., Krogager, M. L., Skals, R. K., Appel, E. V. R., Have, C. T., Grarup, N., Pedersen, O., Jeppesen, J. L., Pedersen, O. D., Dominguez, H., Dixen, U., Engstrøm, T., Tønder, N., Roden, D. M., Stender, S., Gislason, G. H., Enghusen-Poulsen, H., Hansen, T., Køber, L., Torp-Pedersen, C., & 1 othersWeeke, P. E., 2019, In: P L o S One. 14, 2, 12 p., e0211690.
Research output: Contribution to journal › Journal article › Research › peer-review
Associations between birth weight and glucose intolerance in adulthood among Greenlandic Inuit
Rønn, P. F., Jørgensen, M. E., Smith, L. S., Bjerregaard, P., Dahl-Petersen, I. K., Larsen, C. V. L., Grarup, N. & Andersen, G. S., Apr 2019, In: Diabetes Research and Clinical Practice. 150, p. 129-137 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
3 Citations (Scopus)
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits
Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L., & 132 othersRichardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W-J., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kernson, N. D., Larson, N. B., Lin, K-H., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W. H-H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpelainen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sorensen, T. I. A., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y-D. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., de Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., 3 Jan 2019, In: American Journal of Human Genetics. 104, 1, p. 112-138 27 p.
Research output: Contribution to journal › Journal article › Research › peer-review
35 Citations (Scopus)
Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity
Dallner, O. S., Marinis, J. M., Lu, Y-H., Birsoy, K., Werner, E., Fayzikhodjaeva, G., Dill, B. D., Molina, H., Moscati, A., Kutalik, Z., Marques-Vidal, P., Kilpeläinen, T. O., Grarup, N., Linneberg, A., Zhang, Y., Vaughan, R., Loos, R. J. F., Lazar, M. A. & Friedman, J. M., 1 Mar 2019, In: Nature Medicine. 25, 3, p. 507-530 24 p.
Research output: Contribution to journal › Journal article › Research › peer-review
36 Citations (Scopus)

Niels Grarup

Personal profile

Current research

CV

Expertise related to UN Sustainable Development Goals

Keywords

Fingerprint

Abdominal adiposity and cardiometabolic risk factors in children and adolescents: A Mendelian randomization analysis

ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations

Associations between birth weight and glucose intolerance in adulthood among Greenlandic Inuit

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

Niels Grarup

Personal profile

Current research

CV

Expertise related to UN Sustainable Development Goals

Keywords

Fingerprint

Research output