Marie Kveiborg

CV

Academic degrees

• 2000: Ph.D. Faculty of Science, Aarhus University, Denmark
  
  
• 1998: Cand.Scient. Faculty of Science, Aarhus University, Denmark
  
  

Scientific positions & Education

• 01/01/2017 – present: Associate Professor and Group Leader at Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH)

• 09/05/2015 – 30/04/2016: Adoption leave

• 09/11/2010 – 01/08/2011: Adoption leave

• 01/10/2008 – 31/12/2009: Visiting Scientist, London Research Institute, UK

• 01/07/2008 – 31/12/2016: Associate Professor at the Department of Biomedical Sciences (BMI) & BRIC, UCPH

• 01/01/2006 – 30/06/2008: Assistant Professor, Prof. Ulla Wewer’s laboratory, Department of Biomedical Sciences, Faculty of Health Sciences, UCPH

• 01/10/2002 – 31/12/2005: Postdoctoral Fellow, Prof. Ulla Wewer’s laboratory, Institute of Molecular Pathology, Faculty of Health Sciences, UCPH. Funded by a post doc-stipend from the Danish Medical Research Council.

• 01/06/2000 – 30/09/2002: Postdoctoral Fellow, Prof. Roland Baron’s laboratory, Department of Cell Biology, Yale University School of Medicine, USA. Funded by a post doc-stipend from the Danish Natural Science Research Council.

• 01/04/1996 - 31/05/2000: Doctoral studies (4+4 scheme) in Profs. Moustapha Kassem and Brian F. C. Clark’s laboratories, Institute of Molecular and Structural Biology, Faculty of Science, Aarhus University. Funded by a Ph.D.-stipend from Aarhus University.

• 01/09/1991 – 31/03/1996: Graduate studies in Chemistry and Biotechnology at Aarhus University.

Teaching and supervision

Management and teaching of molecular pathology courses for undergraduate and graduate MD and molecular biomedicine students. Supervision of several bachelor, master and phd students.

Scientific contributions

Published 34 original articles in international peer-reviewed scientific journals, 2 invited reviews, and 3 book chapters. Handling Editor for Scientific Reports (Nature Publishing Group). Evaluation panel member at the Norwegian Cancer Society. Invited referee for multiple international scientific journals (e.g. American Journal of Pathology, Biochemical Journal, Journal of Biological Chemistry, Journal of Cell Science, Journal of Cellular Biochemistry, Molecular Biology of the Cell, PLoS ONE, Protein Science, The International Journal of Biochemistry & Cell Biology) and grant applications (e.g. Cancer Research UK, Breast Cancer Campaign)

Recent invited scientific presentations

• 2017: Symposium “Bridge over troubled water – Proteases in disease and aging”, Germany

• 2017: Research Seminar, Barts Cancer Institute, London, England

• 2016: Symposium “Metalloproteases and their inhibitors”, University of Oxford, England

• 2016: Research Seminar, University of Freiburg, Germany

• 2015: Plenary lecturer at the Summer School “Protease & Pathophysiology”, Germany

• 2014: Gordon Research Conference ” Protein Processing, Trafficking & Secretion”, NH, US

• 2014: 46^th Sandbjerg Meeting on Membrane Transport, Sønderborg, Denmark

• 2013: Research Seminar, Biomedicum, University of Helsinki, Finland

• 2013: Research Seminar, University of Pittsburgh, PA, USA

• 2013: Gordon Research Conference ”Matrix Metalloproteinases”, Il Ciocco, Italy

Scientific grants

PI and co-PI on grants from The Danish Medical Research Council, The Danish Cancer Society, The Novo Nordisk Foundation, and The Lundbeck Foundation as well as several private foundations (e.g. Friis, Haensch, Munksholm).

Scientific awards

• 2005: Young Investigator Award, Faculty of Health Sciences, Copenhagen University.
• 2002: Young Investigator Award, the American Society of Bone and Mineral Research.
• 1999: Young Investigator Award, the European Calcified Tissues Society.

Scientific memberships

• The Danish Society for Biochemistry and Molecular Biology
• Danish Association for Cancer Research
• Danish Society for Matrix Biology
• Federation of European Biochemical Societies (FEBS)
• The American Society for Cell Biology (ASCB)

Primary fields of research

• ADAM proteases and pericellular proteolysis
• Protein trafficking
• Cancer cell biology

Current research

We investigate transmembrane ADAMs (A Disintegrin and Metalloproteases) and their interaction partners. Most notably, ADAMs are essential for growth factor receptor signalling and engagement of adhesion molecules, with major impact on diseases like cancer and inflammatory conditions. Our overall scientific objective is to understand fundamental properties and mechanisms of ADAM proteases in normal cell biology and in disease – especially cancer.

Recently, we have taken a high-through put screen approach to identify novel ADAM substrates, interaction partners and regulators, and our studies range from biochemical structure/function analyses to murine disease models.

More specifically, we examine the complex interplay between ADAM proteases and other cell surface proteins (e.g. integrins and MMPs) and how this contributes to tumour cell proliferation, migration/invasion and survival. We also investigate the subcellular localization and dynamic trafficking of ADAM proteases, and the role of intracellular protein kinases (e.g. Src and PKC), adaptor (e.g. Grb2 and endophilin) and transport proteins (e.g. PACS) in their spatiotemporal regulation.

Teaching

Course leader and lecturer at undergraduate courses in Molecular Pathology for Molecular Biomedicine students and in Basic Pathology for MD-students. Involved in PhD courses on extracellular proteolysis and matrix biology.

Short presentation

Marie Kveiborg (MK) received her PhD in Molecular Biology in 2000. Her thesis work on cytokines and growth factors in bone cell differentiation was performed in the laboratories of Profs. Moustapha Kassem and Brian Clark at the Department of Molecular and Structural Biology, University of Aarhus.

In 2000 – 2002, MK was a post-doctoral fellow in the laboratory of Prof. Roland Baron at Yale University School of Medicine, New Haven, USA, investigating the role of AP-1 transcription factors in mesenchymal stem cell differentiation.

In 2002, MK was awarded a 3-year post-doc stipend from the Danish Medical Research Council to study the transmembrane metalloprotease ADAM12 in mesenchymal cell differentiation, in the laboratory of Prof. Ulla Wewer, at Institute of Molecular Pathology, University of Copenhagen. Continuing her work on ADAM12 functions in normal cell biology as well as in cancer, MK was employed as an Assistant Professor at the Department of Biomedical Sciences, University of Copenhagen during the period 2005-2008.

In 2008, she was appointed Associate Professor at the Department and since then, she has broadened her studies to other ADAM proteases, focusing on intracellular ADAM protein trafficking and the role of kinases, adaptors and transport molecules in their spatiotemporal regulation.