Research output per year
Research output per year
Personal profile
Short presentation
Dr. Manimozhiyan Arumugam leads the Microbiome Systems Biology research group, investigating how health and diseases are influenced by our gut microbiome; how the gut microbiome interacts with the host and environmental factors; and how we can therapeutically modulate the gut microbiome to improve health. His research is interdisciplinary, combining metagenomics (a technique to study gut microbiome) and other host-microbial multi-omics readouts to study host-microbial cross-talk. He is the principal investigator in several externally funded studies investigating the role of gut microbiome in multiple sclerosis (Lundbeck Foundation), obesity (Novo Nordisk Foundation), liver diseases (EU Horizon 2020), ageing (Danish Independent Research Council) and producing antimicrobial peptides (Danish Independent Research Council).
Dr. Arumugam received his PhD in computational biology from the European Molecular Biology Laboratory (Heidelberg) in 2010.
Masters Thesis Opportunities in Bioinformatics
Highly motivated Masters students are invited to perform their thesis or project work in our group. We prefer students with experience in programming and/or high performance computing. Background in biology is not necessary! Please check out this flyer!
We are always looking for excellent researchers to join our group
| 1. | Postdoctoral fellows in bioinformatics or microbiome research: | |
| Postdoctoral opportunities are available for outstanding candidates with experience and background in bioinformatics and human gut microbiome. If you like our research and are interested in joining our group, please send me an email. | ||
| 2. | PhD fellows in bioinformatics or microbiome research: | |
| We are always looking for highly motivated PhD students to join us. If you like our research and are interested in joining our group, please send me an email. International students can also apply to the Copenhagen Bioscience PhD Program where I am a participating supervisor. | ||
Primary fields of research
Human Microbiome, Systems Biology, Bioinformatics, Metagenomics
Current research
Lifestyle changes and lack of physical activity are important factors involved in metabolic disorders. However, emerging evidence suggests that our gut microbiome and their interactions with us play an important role in our health and well-being. An imbalance in the gut microbiome may signify an unhealthy state of the host and contribute to obesity and diabetes pathogenesis.
The Arumugam Group aims to study the interactions between the host and the gut microbiome in order to understand the molecular mechanisms underlying metabolic disorders. The Group takes interdisciplinary approaches combining multi-omics microbiome data to study host-microbial cross-talk. The Group also investigates therapeutic approaches to modulate the gut microbiome towards improving human health.
Fields of interest
Systems Biology, Human Diseases, Genomics, Machine Learning
CV
Education
| May 2010, | Ph.D. Computational Biology | |
| EMBL-Heidelberg, Germany | ||
| Jan 2003, | M.S. Computer Science | |
| Univ. Nebraska-Lincoln, USA | ||
| Jun 1999, | B. Tech. Biotechnology | |
| Anna University, India |
Research Experience
| Feb. 2013 | - | present, | Associate Professor, Group Leader |
| University of Copenhagen, Denmark | |||
| Jun. 2010 | - | July 2012, | Research Scientist |
| EMBL-Heidelberg, Germany | |||
| Sep. 2006 | - | May 2010, | Predoctoral Fellow |
| EMBL-Heidelberg, Germany | |||
| Apr. 2003 | - | Aug. 2006, | Research Associate |
| Washington University in St. Louis, USA |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Comparative metagenomic analysis of the human gut microbiota, European Molecular Biology Laboratory
1 Sept 2006 → 31 May 2010
Award Date: 31 May 2010
EMPRR: A High-dimensional EM-Based Piecewise Regression Algorithm
10 Aug 2000 → 31 Jan 2003
Award Date: 16 Aug 2003
Keywords
- ???Bioinformatik???
Fingerprint
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- 12 Similar Profiles
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Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer
Wirbel, J., Pyl, P. T., Kartal, E., Zych, K., Kashani, A., Milanese, A., Fleck, J. S., Voigt, A. Y., Palleja, A., Ponnudurai, R., Sunagawa, S., Coelho, L. P., Schrotz-King, P., Vogtmann, E., Habermann, N., Niméus, E., Thomas, A. M., Manghi, P., Gandini, S. & Serrano, D. & 15 others, , 1 Apr 2019, In: Nature Medicine. 25, 4, p. 679-689 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Recovery of gut microbiota of healthy adults following antibiotic exposure
Palleja, A., Mikkelsen, K. H., Forslund, S. K., Kashani, A., Allin, K. H., Nielsen, T., Hansen, T. H., Liang, S., Feng, Q., Zhang, C., Pyl, P. T., Coelho, L. P., Yang, H., Wang, J., Typas, A., Nielsen, M. F., Nielsen, H. B., Bork, P., Wang, J. & Vilsbøll, T. & 4 others, , 1 Nov 2018, In: Nature Microbiology. 3, 11, p. 1255-1265 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating microbiome in blood of different circulatory compartments
Schierwagen, R., Alvarez-Silva, C., Madsen, M. S. A., Kolbe, C. C., Meyer, C., Thomas, D., Uschner, F. E., Magdaleno, F., Jansen, C., Pohlmann, A., Praktiknjo, M., Hischebeth, G. T., Molitor, E., Latz, E., Lelouvier, B., Trebicka, J. & Arumugam, M., 1 Mar 2019, In: Gut. 68, 3, p. 578-580Research output: Contribution to journal › Letter › peer-review
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Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
Yu, J., Feng, Q., Wong, S. H., Zhang, D., Liang, Q. Y., Qin, Y., Tang, L., Zhao, H., Stenvang, J., Li, Y., Wang, X., Xu, X., Chen, N., Wu, W. K. K., Al-Aama, J., Nielsen, H. J., Kiilerich, P., Jensen, B. A. H., Yau, T. O. & Lan, Z. & 19 others, , 2017, In: Gut. 66, p. 70-78 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota
Palleja, A., Kashani, A., Allin, K. H., Nielsen, T., Zhang, C., Li, Y., Brach, T., Liang, S., Feng, Q., Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Burgdorf, K. S., Holst, J. J., Madsbad, S., Wang, J., Pedersen, O. B., Hansen, T. & Arumugam, M., 15 Jun 2016, In: Genome Medicine. 8, 13 p., 67.Research output: Contribution to journal › Journal article › Research › peer-review
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A catalog of the mouse gut metagenome
Xiao, L., Feng, Q., Liang, S., Sonne, S. B., Xia, Z., Qiu, X., Li, X., Long, H., Zhang, J., Zhang, D., Liu, C., Fang, Z., Chou, J., Glanville, J., Hao, Q., Kotowska, D. E., Colding, C. S., Licht, T. R., Wu, D. & Yu, J. & 17 others, , 1 Oct 2015, In: Nature Biotechnology. 33, 10, p. 1103-1108 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genomic variation landscape of the human gut microbiome
Schloissnig, S., Arumugam, M., Sunagawa, S., Mitreva, M., Tap, J., Zhu, A., Waller, A., Mende, D. R., Kultima, J. R., Martin, J., Kota, K., Sunyaev, S. R., Weinstock, G. M. & Bork, P., 3 Jan 2013, In: Nature. 493, 7430, p. 45-50 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Enterotypes of the human gut microbiome: [Plus]Corrigendum [Plus]Addendum
Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., Batto, J.-M., dos Santos, M. B. Q., Borruel, N., Casellas, F., Fernandez, L., Gautier, L., Hansen, T., Hattori, M., Hayashi, T., Kleerebezem, M. & Kurokawa, K. & 31 others, , 2011, In: Nature. 473, 7346, p. 174-180 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Activities
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Pharmabiotics Conference 2018
Arumugam, M. (Invited speaker)
15 Mar 2018Activity: Participating in or organising an event types › Organisation of and participation in conference
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Gut Microbiota for Health World Summit 2018
Arumugam, M. (Invited speaker)
10 Mar 2018Activity: Participating in or organising an event types › Organisation of and participation in conference
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25th United European Gastroenterology Week
Arumugam, M. (Invited speaker)
30 Oct 2017Activity: Participating in or organising an event types › Organisation of and participation in conference
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25th United European Gastroenterology Week
Arumugam, M. (Organizer)
30 Oct 2017Activity: Participating in or organising an event types › Organisation of and participation in conference
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53rd Congress of the European Societies of Toxicology
Arumugam, M. (Invited speaker)
11 Sept 2017Activity: Participating in or organising an event types › Organisation of and participation in conference
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12th Copenhagen Bioscience Conference
Arumugam, M. (Organizer)
1 Oct 2017 → 5 Oct 2017Activity: Participating in or organising an event types › Organisation of and participation in conference
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European Microbiome Congress
Arumugam, M. (Invited speaker)
1 Dec 2016Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Wenner-Gren Foundation Symposium
Arumugam, M. (Invited speaker)
16 Jun 2016Activity: Participating in or organising an event types › Participation in workshop, seminar, course
Press/Media
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Gut microbial 'enterotypes' become less clear-cut: Communities of gut bacteria may form a spectrum rather than falling into distinct groups
21/03/2012
1 Media contribution
Press/Media: Press / Media
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Gut Bacteria Falls Into Three Major Types: Every human appears to have a distinct intestinal ecosystem, European researchers report
21/04/2011
1 Media contribution
Press/Media: Press / Media
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Gut-Bacteria Mapping Finds Three Global Varieties
20/04/2011
1 Media contribution
Press/Media: Press / Media