BRIC

2014

New histone supply regulates replication fork speed and PCNA unloading

Mejlvang, J., Feng, Y., Alabert, C., Neelsen, K. J., Jasencakova, Z., Zhao, X., Lees, M., Sandelin, A., Pasero, P., Lopes, M. & Groth, A., 6 Jan 2014, In: Journal of Cell Biology. 204, 1, p. 29-43 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

87 Citations (Scopus)

NKT cell subsets and proinflammatory cytokine changes in mice as a result of a natural Pasteurella pneumotropica infection.

Issazadeh-Navikas, S. & Liu, Y., 2014

Research output: Other contribution › Net publication - Internet publication › Research › peer-review

Nuclear stability and transcriptional directionality separate functionally distinct RNA species

Andersson, R., Refsing Andersen, P., Valen, E., Core, L. J., Lange, J. B., Boyd, M., Jensen, T. H. & Sandelin, A. G., 2014, In: Nature Communications. 5, 10 p., 5336.

Research output: Contribution to journal › Journal article › Research › peer-review

88 Citations (Scopus)

Oncogenic fusion proteins expressed in immature hematopoietic cells fail to recapitulate the transcriptional changes observed in human AML

Rapin, N. & Porse, B. T., 9 Jun 2014, In: Oncogenesis. 3, p. 1-5 5 p., e106.

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer

Tschaharganeh, D. F., Xue, W., Calvisi, D. F., Evert, M., Michurina, T. V., Dow, L. E., Banito, A., Katz, S. F., Kastenhuber, E. R., Weissmueller, S., Huang, C-H., Lechel, A., Andersen, J. B., Capper, D., Zender, L., Longerich, T., Enikolopov, G. & Lowe, S. W., 31 Jul 2014, In: Cell. 158, 3, p. 579-92 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

104 Citations (Scopus)

Peer review and reproducibility. Crisis or time for course correction?

Couchman, J. R., Jan 2014, In: Journal of Histochemistry and Cytochemistry. 62, 1, p. 9-10 2 p.

Research output: Contribution to journal › Editorial

9 Citations (Scopus)

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

Piunti, A., Rossi, A., Cerutti, A., Albert, M., Jammula, S., Scelfo, A., Cedrone, L., Fragola, G., Pålsson, L. E., Koseki, H., Testa, G., Casola, S., Helin, K., d'Adda di Fagagna, F. & Pasini, D., 14 Apr 2014, In: Nature Communications. 5, p. 3649

Research output: Contribution to journal › Journal article › Research › peer-review

56 Citations (Scopus)

Positron emission tomography/computed tomography for optimized colon cancer staging and follow up

Engelmann, B. E., Loft, A., Kjær, A., Nielsen, H. J., Berthelsen, A. K., Binderup, T., Brinch, K., Brünner, N., Gerds, T. A., Høyer-Hansen, G., Kristensen, M. H., Kurt, E. Y., Latocha, J. E., Lindblom, G., Sloth, C. & Højgaard, L., Feb 2014, In: Scandinavian Journal of Gastroenterology. 49, 2, p. 191-201 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

De Raedt, T., Beert, E., Pasmant, E., Luscan, A., Brems, H., Ortonne, N., Helin, K., Hornick, J. L., Mautner, V., Kehrer-Sawatzki, H., Clapp, W., Bradner, J., Vidaud, M., Upadhyaya, M., Legius, E. & Cichowski, K., 9 Oct 2014, In: Nature.

Research output: Contribution to journal › Journal article › Research › peer-review

251 Citations (Scopus)

Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression

Galli, G. G., Multhaupt, H. A., Carrara, M., Honnens de Lichtenberg, K., Christensen, I. B. J., Linnemann, D., Santoni-Rugiu, E., Calogero, R. A. & Lund, A. H., 19 Jun 2014, In: Oncogene.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

Prognostic significance of circulating intact and cleaved forms of urokinase plasminogen activator receptor in inoperable chemotherapy treated cholangiocarcinoma patients

Grunnet, M., Christensen, I. J., Lassen, U., Jensen, L. H., Lydolph, M., Lund, I. K., Thurison, T., Høyer-Hansen, G. & Mau-Sørensen, M., May 2014, In: Clinical Biochemistry. 47, 7-8, p. 599-604 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Regulation of Axonal Midline Guidance by Prolyl 4-Hydroxylation in Caenorhabditis elegans

Torpe, N. & Pocock, R. D. J., 3 Dec 2014, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 49, p. 16348-57 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation

Rishi, L., Hannon, M., Salomè, M., Hasemann, M., Frank, A-K., Campos, J., Timoney, J., O'Connor, C., Cahill, M. R., Porse, B. & Keeshan, K., 10 Apr 2014, In: Blood. 123, 15, p. 2389-400 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

Reliable reference miRNAs for quantitative gene expression analysis of stress responses in Caenorhabditis elegans

Kagias, K., Podolska, A. & Pocock, R. D. J., 21 Mar 2014, In: BMC Genomics. 15, 1, p. 222

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Revolution in the Polycomb hierarchy

Vacher-Comet, I. & Helin, K., 3 Jul 2014, In: Nature Structural and Molecular Biology. 21, 7, p. 573-5 3 p.

Research output: Contribution to journal › Review › peer-review

21 Citations (Scopus)

shRNA screening identifies JMJD1C as being required for leukemia maintenance

Sroczynska, P., Cruickshank, V. A., Bukowski, J-P., Miyagi, S., Bagger, F. O., Walfridsson, J., Schuster, M. B., Porse, B. & Helin, K., 20 Mar 2014, In: Blood (online).

Research output: Contribution to journal › Journal article › Research › peer-review

53 Citations (Scopus)

spliceR: an R package for classification of alternative splicing and prediction of coding potential from RNA-seq data

Vitting-Seerup, K., Porse, B. T., Sandelin, A. & Waage, J., 23 Mar 2014, In: B M C Bioinformatics. 15, p. 1-7 7 p., 81.

Research output: Contribution to journal › Journal article › Research › peer-review

50 Citations (Scopus)

3196 Downloads (Pure)

Structured RNAs and synteny regions in the pig genome

Anthon, C., Tafer, H., Havgaard, J. H., Thomsen, B., Hedegaard, J., Seemann, E. S., Pundhir, S., Kehr, S., Bartschat, S., Nielsen, M., Nielsen, R. O., Fredholm, M., Stadler, P. F. & Gorodkin, J., 10 Jun 2014, In: BMC Genomics. 15, 27 p., 459.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

913 Downloads (Pure)

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells

Langlois, T., da Costa Reis Monte Mor, B., Lenglet, G., Droin, N., Marty, C., Le Couédic, J-P., Almire, C., Auger, N., Mercher, T., Delhommeau, F., Christensen, J. A., Helin, K., Debili, N., Fuks, F., Bernard, O. A., Solary, E., Vainchenker, W. & Plo, I., Aug 2014, In: Stem Cells.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines

Kirkegaard, T., Yde, C. W., Kveiborg, M. & Lykkesfeldt, A. E., Jul 2014, In: International Journal of Oncology. 45, 1, p. 393-400 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

The Demethylase JMJD2C Localizes to H3K4me3 Positive Transcription Start Sites and Is Dispensable for Embryonic Development

Pedersen, M. T., Agger, K., Laugesen, A., Johansen, J. V., Cloos, P. A. C., Christensen, J. A. & Helin, K., Mar 2014, In: Molecular and Cellular Biology.

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

The functional consequences of intron retention: Alternative splicing coupled to NMD as a regulator of gene expression

Ge, Y. & Porse, B. T., Mar 2014, In: BioEssays.

Research output: Contribution to journal › Review › peer-review

96 Citations (Scopus)

The Histone Lysine Demethylase JMJD3/KDM6B Is Recruited to p53 Bound Promoters and Enhancer Elements in a p53 Dependent Manner

Williams, K., Christensen, J., Rappsilber, J., Nielsen, A. L., Johansen, J. V. & Helin, K., 5 May 2014, In: PLOS ONE. 9, 5, p. e96545

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

2607 Downloads (Pure)

Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication

Kamalyukova, I. M., Young, C., Strømme, C. B., Menard, P., Jasencakova, Z., Mejlvang, J., Ask, K., Ploug, M., Nielsen, M. L., Jensen, O. N. & Groth, A., 6 Mar 2014, In: Nature Communications. 5, p. 3394

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

Transcriptional profiling of the human fibrillin/LTBP gene family, key regulators of mesenchymal cell functions

Davis, M. R., Andersson, R., Severin, J., de Hoon, M., Bertin, N., Baillie, J. K., Kawaji, H., Sandelin, A. G., Forrest, A. R. R. & Summers, K. M., May 2014, In: Molecular Genetics and Metabolism. 112, 3, p. 73-83 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Tumor stromal phenotypes define VEGF sensitivity-letter

Van den Eynden, G. G., Bird, N. C., Dirix, L. Y., Eefsen, R. L., Gao, Z-H., Høyer-Hansen, G., Illemann, M., Majeed, A. W., Metrakos, P., Reynolds, A. R., Vainer, B., van Dam, P-J., Van Laere, S. J., Vermeulen, P. B., Vidal-Vanaclocha, F., Brodt, P. & Liver Metastasis Research Network, 1 Oct 2014, In: Clinical Cancer Research. 20, 19, p. 5140

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells

Oka, Y., Varmark, H., Vitting-Seerup, K., Beli, P., Waage, J. E., Hakobyan, A., Mistrik, M., Choudhary, C. R., Rohde, M., Bekker-Jensen, S. & Mailand, N., Sept 2014, In: E M B O Reports. 15, 9, p. 956-964 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

uPAR Targeted Radionuclide Therapy with 177Lu-DOTA-AE105 Inhibits Dissemination of Metastatic Prostate Cancer

Persson, M., Juhl, K., Rasmussen, P., Brandt-Larsen, M., Madsen, J., Ploug, M. & Kjær, A., 4 Aug 2014, In: Molecular Pharmaceutics. 11, 8, p. 2796–2806 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

Urokinase-type plasminogen activator receptor (uPAR) on tumor-associated macrophages is a marker of poor prognosis in colorectal cancer

Illemann, M., Laerum, O. D., Hasselby, J. P., Thurison, T., Høyer-Hansen, G., Nielsen, H. J., Christensen, I. J. & Danish Study Group on Early Detection of Colorectal Cancer, Aug 2014, In: Cancer Medicine. 3, 4, p. 855-64 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

50 Downloads (Pure)

2013

Acute Genome-wide effects of Rosiglitazone on PPARγ transcriptional networks in Adipocytes

Haakonsson, A. K., Madsen, M. S., Nielsen, R., Sandelin, A. G. & Mandrup, S., 1 Sept 2013, In: Molecular Endocrinology. 27, 9, p. 1536-1549 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

ADAM12

Kveiborg, M., Fröhlich, C., Albrechtsen, R. & Wewer, U. M., 29 Aug 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 1. p. 1114-1122 9 p.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins

Frohlich, C., Klitgaard, M., Noer, J. B., Kotzsch, A., Nehammer, C., Kronqvist, P., Berthelsen, J., Blobel, C., Kveiborg, M., Albrechtsen, R. & Wewer, U. M., 15 May 2013, In: Biochemical Journal. 452, 1, p. 97-109 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth

Albrechtsen, R., Kveiborg, M., Hansen, D. S., Vikeså, J., Noer, J. B., Kotzsh, A., Nielsen, F. C., Wewer, U. M. & Frohlich, C., 15 Oct 2013, In: Journal of Cell Science. 126, 20, p. 4707-20 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

41 Citations (Scopus)

Alerting the immune system via stromal cells is central to the prevention of tumor growth

Navikas, S., 1 Dec 2013, In: OncoImmunology. 2, 12, p. e27091

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Allosteric inactivation of a trypsin-like serine protease by an antibody binding to the 37- and 70-loops

Kromann-Hansen, T., Lund, I. K., Liu, Z., Andreasen, P. A., Høyer-Hansen, G. & Sørensen, H. P., 8 Oct 2013, In: Biochemistry. 52, 40, p. 7114-26 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation

Ambjørn, M., Dubreuil, V., Miozzo, F., Nigon, F., Møller, B., Navikas, S., Berg, J., Lees, M. & Sap, J., 13 Jun 2013, In: PloS one. 8, 6, p. e65371

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP

Shiryaev, S. A., Remacle, A. G., Golubkov, V. S., Ingvarsen, S., Porse, A., Behrendt, N., Cieplak, P. & Strongin, A. Y., 2 Dec 2013, In: Oncogenesis. 2, p. e80

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state

Pedersen, M. E., Snieckute, G., Kagias, K., Nehammer, C., Multhaupt, H. A. B., Couchman, J. R. & Pocock, R., 20 Sept 2013, In: Science. 341, 6152, p. 1404-8 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

59 Citations (Scopus)

Antiinflammatory properties of a peptide derived from interleukin-4

Klementiev, B., Enevoldsen, M. N., Li, S., Carlsson, R., Liu, Y., Navikas, S., Bock, E. & Berezin, V., Oct 2013, In: Cytokine. 64, 1, p. 112-21 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode

Tsushima, H., Malabarba, M. G., Confalonieri, S., Senic-Matuglia, F., Verhoef, L. G. G. C., Bartocci, C., D'Ario, G., Cocito, A., Di Fiore, P. P. & Salcini, A. E., 12 Feb 2013, In: PloS one. 8, 2, p. e56383

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

1144 Downloads (Pure)

Biological techniques: An embryonic view of tumour development

Schweiger, P. J. & Jensen, K. B., 12 Sept 2013, In: Nature. 501, 7466, p. 171-2 2 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Catalytic-independent roles of UTX-1 in C. elegans development

Vandamme, J. & Salcini, A. E., 1 Apr 2013, In: Worm. 2, 2, p. e22188

Research output: Contribution to journal › Journal article › Research › peer-review

Cdc42 promotes host defenses against fatal infection

Lee, K., Boyd, K. L., Parekh, D. V., Kehl-Fie, T. E., Baldwin, H. S., Brakebusch, C., Skaar, E. P., Boothby, M. & Zent, R., Aug 2013, In: Infection and Immunity. 81, 8, p. 2714-2723 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Cell cycle, differentiation and disease

Musacchio, A. & Helin, K., Dec 2013, In: Current Opinion in Cell Biology. 25, 6, p. 673-5 3 p.

Research output: Contribution to journal › Review › peer-review

2 Citations (Scopus)

CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression

Egan, C. M., Nyman, U., Skotte, J., Streubel, G., Turner, S., O'Connell, D. J., Rraklli, V., Dolan, M. J., Chadderton, N., Hansen, K., Farrar, G. J., Helin, K., Holmberg, J. & Bracken, A. P., 12 Aug 2013, In: Developmental Cell. 26, 3, p. 223-36 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

67 Citations (Scopus)

Chromatin proteins and modifications as drug targets

Helin, K. & Dhanak, D., 24 Oct 2013, In: Nature. 502, 7472, p. 480-8 9 p.

Research output: Contribution to journal › Review › peer-review

307 Citations (Scopus)

1732 Downloads (Pure)

Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

Köpper, F., Bierwirth, C., Schön, M., Kunze, M., Elvers, I., Kranz, D., Saini, P., Menon, M. B., Walter, D., Sørensen, C. S., Gaestel, M., Helleday, T., Schön, M. P. & Dobbelstein, M., 15 Oct 2013, In: PNAS Early Edition. 110, 42, p. 16856-61 6 p.

Research output: Contribution to journal › Journal article › Research

51 Citations (Scopus)

Detection of reverse transcriptase termination sites using cDNA ligation and massive parallel sequencing

Kielpinski, L. J., Boyd, M., Sandelin, A. & Vinther, J., 2013, In: Methods in molecular biology (Clifton, N.J.). 1038, p. 213-31 19 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis

Madsen, D. H., Jürgensen, H. J., Ingvarsen, S., Melander, M. C., Albrechtsen, R., Hald, A., Holmbeck, K., Bugge, T. H., Behrendt, N. & Engelholm, L. H., 5 Aug 2013, In: PloS one. 8, 8, p. e71261

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding

Schoofs, T., Rohde, C., Hebestreit, K., Klein, H-U., Göllner, S., Schulze, I., Lerdrup, M., Dietrich, N., Agrawal-Singh, S., Witten, A., Stoll, M., Lengfelder, E., Hofmann, W-K., Schlenke, P., Büchner, T., Hansen, K., Berdel, W. E., Rosenbauer, F., Dugas, M. & Müller-Tidow, C., 3 Jan 2013, In: Blood. 121, 1, p. 178-87 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

52 Citations (Scopus)

Research output

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