No photo of Simon Holst Bekker-Jensen
20062019

Research activity per year

Personal profile

Primary fields of research

The overarching aim for our group is to understand the molecular details of cellular stress responses and how they contribute to human diseases such as cancer and aging-related maladies. We are especially interested in understanding the mechanisms by which the MAP kinases p38 and JNK become activated in response to cellular stress insults such as ribosomal impairment, oxidative stress and high osmolarity, and how such signaling drives or protect against pathological cellular changes. Importantly, the same signaling pathways are crucial for inflammatory responses, adding to the relevance of our work for a range of human diseases.

Current research

Mechanisms of MAP kinase activation after diverse stress stimuli.
The molecular mechanisms responsible for activation of p38 and JNK after stress stimuli are vastly understudied compared to the mechanisms governing activation of these kinases after extra-cellular receptor-mediated stimulation. In an attempt to fill this gap in our understanding of cellular stress responses, we are working to identify the unknown or poorly studied signalling components working upstream of MAP kinases. To this end we employ siRNA screens and high-content microscopy techniques combined with a range of biochemical and cell biological techniques.

Identification of novel stress signaling pathways.
Employing proteomics, we are continuously searching for new cellular target of p38 and JNK signalling. We have uncovered a number of such targets, and we are currently undertaking detailed investigation of their biological ramifications. Several of these projects focus on RNA-binding proteins, and regulation of post-transcriptional gene regulation is a common denominator for many effector pathways in cellular stress as well as inflammatory responses.

Requirement of cellular stress responses for cancer development and tumour cell maintenance.
Cancer cells are more metabolically active than normal healthy cells, and consequently they have an increased requirement for functional stress signalling pathways to combat the detrimental effects of reactive oxygen species and other metabolic by-products. We hypothesize that these pathways will represent future targets for therapeutic intervention in cancer therapy. We are investigating these ideas in both cell culture and mouse models.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Keywords

  • Faculty of Health and Medical Sciences
  • Cell stress
  • MAP kinases
  • Ageing
  • Cell biology

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