Research output per year
Research output per year
Personal profile
Education/Academic qualification
Interfering with membrane type matrix metalloproteases in processes of extracellular matrix turnover
Award Date: 13 Apr 2012
Award Date: 14 May 2007
External positions
Biopharmaceuticals Research Unit, Novo Nordisk A/S, Måløv, Denmark.
1 Jul 2013 → 31 Dec 2014
Biopharmaceuticals Research Unit, Novo Nordisk A/S, Måløv, Denmark.
1 Jun 2012 → 30 Jun 2013
The Finsen Laboratory, Faculty of Health Sciences, Rigshospitalet, University of Copenhagen
1 Jun 2007 → 28 Feb 2008
Fingerprint
Dive into the research topics where Signe Ziir Ingvarsen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers
Nielsen, C. F., van Putten, S. M., Lund, I. K., Melander, M. C., Nørregaard, K. S., Jürgensen, H. J., Reckzeh, K., Christensen, K. R., Ingvarsen, S. Z., Gårdsvoll, H., Jensen, K. E., Hamerlik, P., Engelholm, L. H. & Behrendt, N., 2017, In: OncoTarget. 8, 27, p. 44605-44624 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180
Engelholm, L. H., Carlsen Melander, E. M., Hald, A., Persson, M., Madsen, D. H., Jürgensen, H. J., Johansson, K., Nielsen, C., Nørregaard, K. S., Ingvarsen, S. Z., Kjaer, A., Trovik, C. S., Lærum, O. D., Bugge, T. H., Eide, J. & Behrendt, N., 1 Jan 2016, In: Journal of Pathology. 238, 1, p. 120-33 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells
Gaublomme, D., Buyens, T., De Groef, L., Stakenborg, M., Janssens, E., Ingvarsen, S., Porse, A., Behrendt, N. & Moons, L., Jun 2014, In: Journal of Neurochemistry. 129, 6, p. 966-979 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP
Shiryaev, S. A., Remacle, A. G., Golubkov, V. S., Ingvarsen, S., Porse, A., Behrendt, N., Cieplak, P. & Strongin, A. Y., 2 Dec 2013, In: Oncogenesis. 2, p. e80Research output: Contribution to journal › Journal article › Research › peer-review
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Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis
Madsen, D. H., Jürgensen, H. J., Ingvarsen, S., Melander, M. C., Albrechtsen, R., Hald, A., Holmbeck, K., Bugge, T. H., Behrendt, N. & Engelholm, L. H., 5 Aug 2013, In: PloS one. 8, 8, p. e71261Research output: Contribution to journal › Journal article › Research › peer-review
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Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis
Ingvarsen, S., Porse, A., Erpicum, C., Maertens, L., Jürgensen, H. J., Madsen, D. H., Melander, M. C., Gårdsvoll, H., Høyer-Hansen, G., Noel, A., Holmbeck, K., Engelholm, L. H. & Behrendt, N., 12 Apr 2013, In: Journal of Biological Chemistry. 288, 15, p. 10195-204 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis
Madsen, D. H., Jürgensen, H. J., Ingvarsen, S. Z., Melander, M. C., Vainer, B., Egerod, K. L., Hald, A., Rønø, B., Madsen, C. A., Bugge, T. H., Engelholm, L. H. & Behrendt, N., May 2012, In: Journal of Pathology. 227, 1, p. 94-105 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo
Lund, I. K., Rasch, M. G., Ingvarsen, S., Pass, J., Madsen, D. H., Engelholm, L. H., Behrendt, N. & Høyer-Hansen, G., 2012, In: Frontiers in Pharmacology. 3, p. 122Research output: Contribution to journal › Journal article › Research › peer-review