Research output per year
Research output per year
Personal profile
CV
Education
2006 Ph.D., Open University, United Kingdom
2000 M.Sc., University of Copenhagen
Career
2010-
Assistant Professor, Biotech Research and Innovation Centre
2006 - 2010
Post.doc., Biotech Research and Innovation Centre
2004 - 2006
Ph.D. Student, Biotech Research and Innovation Centre
2002 - 2003
Ph.D. Student, European Institute of Oncology, Dept of Experimental Oncology
2000 - 2002
Scientific Assistant, European Institute of Oncology, Dept of Experimental Oncology
Primary fields of research
The role of histone lysine demethylation in cancerCurrent research
The role of histone lysine demethylation in cancerFields of interest
Transcription, chromatin and cancerExpertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance
Agger, K., Nishimura, K., Miyagi, S., Messling, J-E., Rasmussen, K. D. & Helin, K., 3 Oct 2019, In: Blood. 134, 14, p. 1154-1158 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis
Backe, M. B., Jin, C., Andreone, L., Sankar, A., Agger, K., Helin, K., Madsen, A. N., Poulsen, S. S., Bysani, M., Bacos, K., Ling, C., Javier Perone, M., Holst, B. & Mandrup-Poulsen, T., 2019, In: Journal of Diabetes Research. 2019, 15 p., 5451038.Research output: Contribution to journal › Journal article › Research › peer-review
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Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development
Pedersen, M. T., Kooistra, S. M., Radzisheuskaya, A., Laugesen, A., Johansen, J. V., Hayward, D. G., Nilsson, J., Agger, K. & Helin, K., 15 Jul 2016, In: E M B O Journal. 35, 14, p. 1550-64 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
Cooper, S., Grijzenhout, A., Underwood, E., Ancelin, K., Zhang, T., Nesterova, T. B., Anil-Kirmizitas, B., Bassett, A., Kooistra, S. M., Agger, K., Helin, K., Heard, E. & Brockdorff, N., 28 Nov 2016, In: Nature Communications. 7, 8 p., 13661.Research output: Contribution to journal › Journal article › Research › peer-review
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Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells
Agger, K., Miyagi, S., Pedersen, M. T., Kooistra, S. M., Johansen, J. V. & Helin, K., 1 Jun 2016, In: Genes & Development. 30, 11, p. 1278-88 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Demethylase JMJD2C Localizes to H3K4me3 Positive Transcription Start Sites and Is Dispensable for Embryonic Development
Pedersen, M. T., Agger, K., Laugesen, A., Johansen, J. V., Cloos, P. A. C., Christensen, J. A. & Helin, K., Mar 2014, In: Molecular and Cellular Biology.Research output: Contribution to journal › Journal article › Research › peer-review
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Histone lysine demethylases as targets for anticancer therapy
Højfeldt, J. W., Agger, K. & Helin, K., Dec 2013, In: Nature Reviews. Drug Discovery. 12, 12, p. 917-30 14 p.Research output: Contribution to journal › Review › peer-review
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Inhibitors of histone demethylases
Lohse, B., Kristensen, J. L., Kristensen, L. H., Agger, K., Helin, K., Gajhede, M. & Clausen, R. P., 15 Jun 2011, In: Bioorganic & Medicinal Chemistry. 19, 12, p. 3625-3636 11 p.Research output: Contribution to journal › Review › peer-review