Alerting the immune system via stromal cells is central to the prevention of tumor growth

TY - JOUR

T1 - Alerting the immune system via stromal cells is central to the prevention of tumor growth

AU - Navikas, Shohreh

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Anticancer immunotherapies are highly desired. Conversely, unwanted inflammatory or immune responses contribute to oncogenesis, tumor progression, and cancer-related death. For non-immunogenic therapies to inhibit tumor growth, they must promote, not prevent, the activation of anticancer immune responses. Here, the central immunoregulatory role of brain-specific stromal cells and neurons as well as their ability to maintain an immunological balance and prevent the development of glioblastoma is discussed.

AB - Anticancer immunotherapies are highly desired. Conversely, unwanted inflammatory or immune responses contribute to oncogenesis, tumor progression, and cancer-related death. For non-immunogenic therapies to inhibit tumor growth, they must promote, not prevent, the activation of anticancer immune responses. Here, the central immunoregulatory role of brain-specific stromal cells and neurons as well as their ability to maintain an immunological balance and prevent the development of glioblastoma is discussed.

U2 - 10.4161/onci.27091

DO - 10.4161/onci.27091

M3 - Journal article

C2 - 24501690

SN - 2162-4011

VL - 2

SP - e27091

JO - OncoImmunology

JF - OncoImmunology

IS - 12

ER -