Catalytic-independent roles of UTX-1 in C. elegans development

Julien Vandamme; Anna Elisabetta Salcini

doi:10.4161/worm.22188

Catalytic-independent roles of UTX-1 in C. elegans development

Julien Vandamme, Anna Elisabetta Salcini

Abstract

We recently analyzed the functional roles of UTX-1 during development. utx-1 is an essential gene required for the correct embryonic and post-embryonic development of C. elegans, and it displays an H3K27me3 demethylase activity. Rescue experiments demonstrated that the enzymatic activity of UTX-1 is not relevant for its role in development. The phenotypes associated with loss of UTX-1 might, instead, be a result of compromised functions of an UTX-1-containing complex. Here we discuss the possible mechanisms by which UTX-1 contributes to normal development.

Original language	English
Journal	Worm
Volume	2
Issue number	2
Pages (from-to)	e22188
ISSN	2162-4046
DOIs	https://doi.org/10.4161/worm.22188
Publication status	Published - 1 Apr 2013

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abstract = "We recently analyzed the functional roles of UTX-1 during development. utx-1 is an essential gene required for the correct embryonic and post-embryonic development of C. elegans, and it displays an H3K27me3 demethylase activity. Rescue experiments demonstrated that the enzymatic activity of UTX-1 is not relevant for its role in development. The phenotypes associated with loss of UTX-1 might, instead, be a result of compromised functions of an UTX-1-containing complex. Here we discuss the possible mechanisms by which UTX-1 contributes to normal development.",

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AB - We recently analyzed the functional roles of UTX-1 during development. utx-1 is an essential gene required for the correct embryonic and post-embryonic development of C. elegans, and it displays an H3K27me3 demethylase activity. Rescue experiments demonstrated that the enzymatic activity of UTX-1 is not relevant for its role in development. The phenotypes associated with loss of UTX-1 might, instead, be a result of compromised functions of an UTX-1-containing complex. Here we discuss the possible mechanisms by which UTX-1 contributes to normal development.

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Catalytic-independent roles of UTX-1 in C. elegans development

Abstract

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