Chuna Ram Choudhary

2019

Acetylation of intrinsically disordered regions regulates phase separation

Saito, M., Hess, D., Eglinger, J., Fritsch, A. W., Kreysing, M., Weinert, B. T., Choudhary, C. & Matthias, P., Jan 2019, In: Nature Chemical Biology. 15, 1, p. 51-61

Research output: Contribution to journal › Journal article › Research › peer-review

60 Citations (Scopus)

Analysis and Interpretation of Protein Post-Translational Modification Site Stoichiometry

Prus, G., Hoegl, A., Weinert, B. T. & Choudhary, C., Nov 2019, In: Trends in Biochemical Sciences. 44, 11, p. 943-960

Research output: Contribution to journal › Review › peer-review

13 Citations (Scopus)

Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation

Hansen, B. K., Gupta, R., Baldus, L., Lyon, D., Narita, T., Lammers, M., Choudhary, C. & Weinert, B. T., 1 Dec 2019, In: Nature Communications. 10, 11 p., 1055.

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

31 Downloads (Pure)

Functions and mechanisms of non-histone protein acetylation

Narita, T., Weinert, B. T. & Choudhary, C., 1 Mar 2019, In: Nature Reviews. Molecular Cell Biology. 20, p. 156-174 19 p.

Research output: Contribution to journal › Review › peer-review

175 Citations (Scopus)

2018

Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint

Wild, T., Budzowska, M., Hellmuth, S., Eibes, S., Karemore, G., Barisic, M., Stemmann, O. & Choudhary, C., 2018, In: Cell Reports. 25, 9, 18 p., 2317-2328.e5.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

63 Downloads (Pure)

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Gupta, R., Somyajit, K., Narita, T., Maskey, E., Stanlie, A., Kremer, M., Typas, D., Lammers, M., Mailand, N., Nussenzweig, A., Lukas, J. & Choudhary, C., 3 May 2018, In: Cell. 173, 4, p. 972-988

Research output: Contribution to journal › Journal article › Research › peer-review

144 Citations (Scopus)

p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

Borisova, M. E., Voigt, A., Tollenaere, M. A. X., Sahu, S. K., Juretschke, T., Kreim, N., Mailand, N., Choudhary, C., Bekker-Jensen, S., Akutsu, M., Wagner, S. A. & Beli, P., 1 Dec 2018, In: Nature Communications. 9, p. 1-16 16 p., 1017.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

98 Downloads (Pure)

STK3 is a therapeutic target for a subset of acute myeloid leukemias

Camgoz, A., Paszkowski-Rogacz, M., Satpathy, S., Wermke, M., Hamann, M. V., von Bonin, M., Choudhary, C., Knapp, S. & Buchholz, F., 22 May 2018, In: OncoTarget. 9, 39, p. 25458-25473 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

Weinert, B. T., Narita, T., Satpathy, S., Srinivasan, B., Hansen, B. K., Schölz, C., Hamilton, W. B., Zucconi, B. E., Wang, W. W., Liu, W. R., Brickman, J. M., Kesicki, E. A., Lai, A., Bromberg, K. D., Cole, P. A. & Choudhary, C., 2018, In: Cell. 174, 1, p. 231-244.e12 27 p.

Research output: Contribution to journal › Journal article › Research › peer-review

91 Citations (Scopus)

2017

Accurate quantification of site-specific acetylation stoichiometry reveals the impact of sirtuin deacetylase CobB on the E. coli acetylome

Weinert, B. T., Satpathy, S., Hansen, B. K., Lyon, D., Jensen, L. J. & Choudhary, C. R., May 2017, In: Molecular and Cellular Proteomics. 16, p. 759-769

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Lasko, L. M., Jakob, C. G., Edalji, R. P., Qiu, W., Montgomery, D., Digiammarino, E. L., Hansen, T. M., Risi, R. M., Frey, R., Manaves, V., Shaw, B., Algire, M., Hessler, P., Lam, L. T., Uziel, T., Faivre, E., Ferguson, D., Buchanan, F. G., Martin, R. L., Torrent, M., & 16 othersChiang, G. G., Karukurichi, K., Langston, J. W., Weinert, B. T., Choudhary, C., de Vries, P., Van Drie, J. H., McElligott, D., Kesicki, E., Marmorstein, R., Sun, C., Cole, P. A., Rosenberg, S. H., Michaelides, M. R., Lai, A. & Bromberg, K. D., 5 Oct 2017, In: Nature. 550, 7674, p. 128-132 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

213 Citations (Scopus)

lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1

Chakraborty, D., Paszkowski-Rogacz, M., Berger, N., Ding, L., Mircetic, J., Fu, J., Iesmantavicius, V., Choudhary, C., Anastassiadis, K., Stewart, A. F. & Buchholz, F., 12 Dec 2017, In: Cell Reports. 21, 11, p. 3012-3021 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

105 Downloads (Pure)

Redox-sensitive alteration of replisome architecture safeguards genome integrity

Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, F., Rask, M-B., Choudhary, C. & Lukas, J., 10 Nov 2017, In: Science. 358, 6364, p. 797-802 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

53 Citations (Scopus)

2016

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex

Starnes, L. M., Su, D., Pikkupeura, L. M., Weinert, B. T., Santos, M. A., Mund, A., Soria, R., Cho, Y-W., Pozdnyakova, I., Kubec Højfeldt, M., Lages Lino Vala, A., Yang, W., López-Méndez, B., Lee, J-E., Peng, W., Yuan, J., Ge, K., Montoya, G., Nussenzweig, A., Choudhary, C. R., & 1 othersDaniel, J. A., 15 Jan 2016, In: Genes & Development. 30, 2, p. 149-163 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

72 Downloads (Pure)

Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover

Nguyen, T. H., Andrejeva, D., Gupta, R., Choudhary, C. R., Hong, X., Eichhorn, P. JA., Loya, A. C. & Cohen, S. M., 29 Mar 2016, In: Cell Discovery. 2, 13 p., 16001.

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

179 Downloads (Pure)

Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance

Pinela da Silva, S. C., Altmannova, V., Luke-Glaser, S., Henriksen, P., Gallina, I., Yang, X., Choudhary, C. R., Luke, B., Krejci, L. & Lisby, M., 15 Mar 2016, In: Genes & Development. 30, 6, p. 700-717 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

161 Downloads (Pure)

SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes

Wagner, S. A., Satpathy, S., Beli, P. & Choudhary, C. R., 1 Sept 2016, In: E M B O Journal. 35, 17, p. 1868-1884

Research output: Contribution to journal › Journal article › Research › peer-review

76 Citations (Scopus)

The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity

Wild, T., Larsen, M. S. Y., Narita, T., Schou, J., Nilsson, J. & Choudhary, C. R., 1 Mar 2016, In: Cell Reports. 14, 8, p. 1829-40 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

2015

Acetylation site specificities of lysine deacetylase inhibitors in human cells

Schölz, C., Weinert, B. T., Wagner, S. A., Beli, P., Miyake, Y., Qi, J., Jensen, L. J., Streicher, W., McCarthy, A. R., Westwood, N. J., Lain, S., Cox, J., Matthias, P., Mann, M., Bradner, J. E. & Choudhary, C. R., 1 Apr 2015, In: Nature Biotechnology. 33, p. 415–423

Research output: Contribution to journal › Journal article › Research › peer-review

159 Citations (Scopus)

Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions

Weinert, B. T., Moustafa, T., Iesmantavicius, V., Zechner, R. & Choudhary, C. R., 3 Nov 2015, In: E M B O Journal. 34, 21, p. 2620-2632 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

77 Citations (Scopus)

Avoiding abundance bias in the functional annotation of posttranslationally modified proteins

Schölz, C., Lyon, D., Refsgaard, J. C., Jensen, L. J., Choudhary, C. R. & Weinert, B. T., 1 Nov 2015, In: Nature Methods. 12, p. 1003-4 2 p.

Research output: Contribution to journal › Comment/debate › Research › peer-review

24 Citations (Scopus)

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

Thorslund, T., Ripplinger, A., Hoffmann, S., Wild, T., Uckelmann, M., Villumsen, B., Narita, T., Sixma, T. K., Choudhary, C. R., Bekker-Jensen, S. & Mailand, N., 19 Nov 2015, In: Nature. 527, 7578, p. 389-93 5 p.

Research output: Contribution to journal › Letter › peer-review

199 Citations (Scopus)

261 Downloads (Pure)

Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits

Acosta-Alvear, D., Cho, M. Y., Wild, T., Buchholz, T. J., Lerner, A. G., Simakova, O., Hahn, J., Korde, N., Landgren, O., Maric, I., Choudhary, C. R., Walter, P., Weissman, J. S. & Kampmann, M., 1 Sept 2015, In: eLife. 4, p. 1-19 e08153.

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells

Bursomanno, S., Beli, P., Khan, A. M., Minocherhomji, S., Wagner, S. A., Bekker-Jensen, S., Mailand, N., Choudhary, C. R., Hickson, I. D. & Liu, Y., Jan 2015, In: DNA Repair. 25, p. 84-96 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells

Ding, L., Paszkowski-Rogacz, M., Winzi, M., Chakraborty, D., Theis, M., Singh, S., Ciotta, G., Poser, I., Roguev, A., Chu, W. K., Choudhary, C. R., Mann, M., Stewart, A. F., Krogan, N. & Buchholz, F., 26 Aug 2015, In: Cell Systems. 1, 2, p. 141-151 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation

Satpathy, S., Wagner, S. A., Beli, P., Gupta, R., Kristiansen, T. A., Malinova, D., Francavilla, C., Tolar, P., Bishop, G. A., Hostager, B. S. & Choudhary, C. R., 1 Jun 2015, In: Molecular Systems Biology. 11, 6, 810.

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

Gibbs-Seymour, I., Oka, Y., Rajendra, E., Weinert, B. T., Passmore, L. A., Patel, K. J., Olsen, J. V., Choudhary, C. R., Bekker-Jensen, S. & Mailand, N., 8 Jan 2015, In: Molecular Cell. 57, 1, p. 150-64 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

79 Citations (Scopus)

2014

Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae

Weinert, B. T., Iesmantavicius, V., Moustafa, T., Schölz, C., Wagner, S. A., Magnes, C., Zechner, R. & Choudhary, C. R., 31 Jan 2014, In: Molecular Systems Biology. 10, 1, p. 716 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

146 Citations (Scopus)

A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response

Blasius, M., Wagner, S. A., Choudhary, C. R., Bartek, J. & Jackson, S. P., 15 Sept 2014, In: Genes & Development. 28, 18, p. 1977-1982 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

Convergence of Ubiquitylation and Phosphorylation Signaling in Rapamycin-Treated Yeast Cells

Iesmantavicius, V., Weinert, B. T. & Choudhary, C. R., Aug 2014, In: Molecular & Cellular Proteomics. 13, 8, p. 1979-92 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

41 Citations (Scopus)

Specificity and commonality of the phosphoinositide-binding proteome analyzed by quantitative mass spectrometry

Jungmichel, S., Sylvestersen, K. B., Choudhary, C. R., Nguyen, S., Mann, M. & Nielsen, M. L., 13 Feb 2014, In: Cell Reports. 6, 3, p. 578-91 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

The growing landscape of lysine acetylation links metabolism and cell signalling

Choudhary, C. R., Weinert, B. T., Nishida, Y., Verdin, E. & Mann, M., Aug 2014, In: Nature Reviews. Molecular Cell Biology. 15, 8, p. 536-50 15 p.

Research output: Contribution to journal › Review › peer-review

725 Citations (Scopus)

Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF-β

J D'Souza, R. C., Knittle, A. M., Nagaraj, N., van Dinther, M., Choudhary, C. R., Ten Dijke, P., Mann, M. & Sharma, K., 22 Jul 2014, In: Science Signaling. 7, 335, p. rs5 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells

Oka, Y., Varmark, H., Vitting-Seerup, K., Beli, P., Waage, J. E., Hakobyan, A., Mistrik, M., Choudhary, C. R., Rohde, M., Bekker-Jensen, S. & Mailand, N., Sept 2014, In: E M B O Reports. 15, 9, p. 956-964 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

2013

Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli

Weinert, B. T., Iesmantavicius, V., Wagner, S. A., Schölz, C., Gummesson, B., Beli, P., Nyström, T. & Choudhary, C. R., 25 Jul 2013, In: Molecular Cell. 51, 2, p. 265-272 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

252 Citations (Scopus)

A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis

Villumsen, B. H., Danielsen, J. R., Povlsen, L., Sylvestersen, K. B., Merdes, A., Beli, P., Yang, Y-G., Choudhary, C. R., Nielsen, M. L., Mailand, N. & Bekker-Jensen, S., 27 Nov 2013, In: E M B O Journal. 32, 23, p. 3029-3040

Research output: Contribution to journal › Journal article › Research › peer-review

73 Citations (Scopus)

Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation

Weinert, B. T., Schölz, C., Wagner, S. A., Iesmantavicius, V., Su, D., Daniel, J. A. & Choudhary, C. R., 29 Aug 2013, In: Cell Reports. 4, 4, p. 842-51 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

377 Citations (Scopus)

OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

Fiil, B. K., Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, S., Mailand, N., Choudhary, C. R., Komander, D. & Gyrd-Hansen, M., 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

144 Citations (Scopus)

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

Poulsen, S. L., Hansen, R. K., Wagner, S. A., van Cuijk, L., van Belle, G. J., Streicher, W., Wikström, M., Choudhary, C. R., Houtsmuller, A. B., Marteijn, J. A., Bekker-Jensen, S. & Mailand, N., 10 Jun 2013, In: Journal of Cell Biology. 201, 6, p. 797-807 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

97 Citations (Scopus)

2012

DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, C., Hartmann-Petersen, R., Lukas, J., Choudhary, C. R., Pocock, R. D. J., Bekker-Jensen, S. & Mailand, N., Nov 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

120 Citations (Scopus)

Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae

Henriksen, P., Wagner, S. A., Weinert, B. T., Sharma, S., Bacinskaja, G., Rehman, M., Juffer, A. H., Walther, T. C., Lisby, M. & Choudhary, C. R., Nov 2012, In: Molecular & Cellular Proteomics. 11, 11, p. 1510-1522 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

182 Citations (Scopus)

Proteomic analyses reveal divergent ubiquitylation site patterns in murinetissues

Wagner, S. A., Beli, P., Weinert, B. T., Schölz, C. F., Kelstrup, C. D., Young, C., Nielsen, M. L., Olsen, J. V., Brakebusch, C. & Choudhary, C. R., Dec 2012, In: Molecular & Cellular Proteomics.

Research output: Contribution to journal › Journal article › Research › peer-review

189 Citations (Scopus)

Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns

Lundby, A., Hansen, K. L., Weinert, B. T., Breinholt Bekker-Jensen, D., Secher, A., Skovgaard, T., Kelstrup, C., Dmytriyev, A., Choudhary, C. R., Lundby, C. & Olsen, J. V., 30 Aug 2012, In: Cell Reports. 2, 2, p. 419-431 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

355 Citations (Scopus)

Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3

Sol, E. M., Wagner, S. A., Weinert, B. T., Kumar, A., Kim, H-S., Deng, C-X. & Choudhary, C. R., 7 Dec 2012, In: PloS one. 7, 12, p. e50545

Research output: Contribution to journal › Journal article › Research › peer-review

97 Citations (Scopus)

Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response

Beli, P., Lukashchuk, N., Wagner, S. A., Weinert, B. T., Olsen, J. V., Baskcomb, L., Mann, M., Jackson, S. P. & Choudhary, C. R., 27 Apr 2012, In: Molecular Cell. 46, 2, p. 212-25 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

196 Citations (Scopus)

SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control

Reddy, P. N. G., Serve, H., Brandts, C. H., Sargin, B., Choudhary, C., Müller-Tidow, C., Berdel, W. E., Stein, S. & Grez, M., 23 Aug 2012, In: Blood. 120, 8, p. 1691-1702 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

Povlsen, L. K., Beli, P., Wagner, S. A., Poulsen, S. L., Sylvestersen, K. B., Poulsen, J. W., Nielsen, M. L., Bekker-Jensen, S., Mailand, N. & Choudhary, C. R., Oct 2012, In: Nature Cell Biology. 14, 10, p. 1089-98 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

156 Citations (Scopus)

2011

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1

Blasius, M., Forment, J. V., Thakkar, N., Wagner, S. A., Choudhary, C. R. & Jackson, S. P., 18 Aug 2011, In: Genome Biology (Online Edition). 12, 8, p. R78

Research output: Contribution to journal › Journal article › Research › peer-review

91 Citations (Scopus)

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

Wagner, S. A., Beli, P., Weinert, B. T., Nielsen, M. L., Cox, J., Mann, M. & Choudhary, C. R., 1 Oct 2011, In: Molecular and Cellular Proteomics. 10, 10, p. M111.013284

Research output: Contribution to journal › Journal article › Research › peer-review

575 Citations (Scopus)

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

Wild, P., Farhan, H., McEwan, D. G., Wagner, S., Rogov, V. V., Brady, N. R., Richter, B., Korac, J., Waidmann, O., Choudhary, C., Dötsch, V., Bumann, D. & Dikic, I., 8 Jul 2011, In: Science. 333, 6039, p. 228-33 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

824 Citations (Scopus)

Chuna Ram Choudhary

Research output

Search results