Research output per year
Research output per year
Personal profile
Current research
DNA-protein crosslinks (DPCs) are common DNA lesions caused by widely used chemotherapeutics, like cisplatin, but also by byproducts of the cellular metabolism, such as aldehydes. If left urepaired DPCs are likely to promote genome instability, predisposing for cancer and aging. Using Xenopus egg extract as a model system, I aim to identify the key factors required for processing DPCs, and to delineate their mechanisms of action. This will be instrumental for understanding how a very common and toxic lesion like a DPC is recognized and repaired also in humans.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts
Larsen, N. B., Gao, A. O., Sparks, J. L., Gallina, I., Wu, R. A., Mann, M., Räschle, M., Walter, J. C. & Duxin, J. P., 7 Feb 2019, In: Molecular Cell. 73, 3, p. 574-588.e7 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
Pinela da Silva, S. C., Altmannova, V., Luke-Glaser, S., Henriksen, P., Gallina, I., Yang, X., Choudhary, C. R., Luke, B., Krejci, L. & Lisby, M., 15 Mar 2016, In: Genes & Development. 30, 6, p. 700-717 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination
Pinela da Silva, S. C., Altmannova, V., Eckert-Boulet, N. V., Kolesar, P., Gallina, I., Hang, L., Chun, I., Arneric, M., Zhao, X., Buron, L. D., Mortensen, U. H., Krejci, L. & Lisby, M., 1 Jun 2016, In: D N A Repair. 42, p. 11-25 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TopBP1-mediated DNA processing during mitosis
Gallina, I., Christiansen, S. K., Pedersen, R. T., Lisby, M. & Østergaard, V. H., 17 Jan 2016, In: Cell Cycle. 15, 2, p. 176-183 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control
Gallina, I., Colding, C. S., Henriksen, P., Beli, P., Nakamura, K., Offman, J., Barfred, D. P., Pinela da Silva, S. C., Hoffmann, E., Groth, A., Choudhary, C. & Lisby, M., Mar 2015, In: Nature Communications. 6, 16 p., 6533.Research output: Contribution to journal › Journal article › Research › peer-review
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TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability
Germann, S. M., Schramke, V., Pedersen, R. T., Gallina, I., Eckert-Boulet, N., Oestergaard, V. H. & Lisby, M., 6 Jan 2014, In: Journal of Cell Biology. 204, 1, p. 45-59 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New aspects of protein stability and turnover in the regulation of genome integrity: the role of Cmr1 and Rad56
Gallina, I., 2013, Department of Biology, Faculty of Science, University of Copenhagen. 195 p.Research output: Book/Report › Ph.D. thesis
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Physical mapping and cloning of RAD56
Mathiasen, D. P., Gallina, I., Germann, S. M., Hamou, W., Eléouët, M., Thodberg, S., Eckert-Boulet, N., Game, J. & Lisby, M., 25 Apr 2013, In: Gene. 519, 1, p. 182-186 5 p.Research output: Contribution to journal › Journal article › Research › peer-review