Research output per year
Research output per year
Personal profile
Short presentation
Hana Sedlackova graduated with MSc from Masaryk University, Brno, Czech Republic . She undertook research project in Lumir Krejci lab (2009-2016), where she focused on biochemical characterization of helicases and nucleases and its role in maintenance of genome integrity.
In 2016, she joined prof Jiri Lukas group at NNF Center for Protein Research as part of the Copenhagen Bioscience PhD Programme. In her PhD project, she studies process of DNA replication and its regulation by the network of multifunctional protein complexes. Combining approaches of biochemistry, molecular biology, genetics and cell biology she is trying to understand the biological significance and balance between two forms of active and inactive MCM helicase (one of the key driver of DNA replication) – the phenomena also known as ‘MCM paradox’.
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Research output
- 3 Journal article
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Stabilization of chromatin topology safeguards genome integrity
Ochs, F., Karemore, G., Miron, E., Brown, J., Sedlackova, H., Rask, M.-B., Lampe, M., Buckle, V., Schermelleh, L., Lukas, J. & Lukas, C., 24 Oct 2019, In: Nature. 574, 7779, p. 571-574 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis
Di Marco, S., Hasanova, Z., Kanagaraj, R., Chappidi, N., Altmannova, V., Menon, S., Sedlackova, H., Langhoff, J., Surendranath, K., Hühn, D., Bhowmick, R., Marini, V., Ferrari, S., Hickson, I. D., Krejci, L. & Janscak, P., 1 Jun 2017, In: Molecular Cell. 66, 5, p. 658-671.e8Research output: Contribution to journal › Journal article › Research › peer-review
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Redox-sensitive alteration of replisome architecture safeguards genome integrity
Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, F., Rask, M.-B., Choudhary, C. & Lukas, J., 10 Nov 2017, In: Science. 358, 6364, p. 797-802 6 p.Research output: Contribution to journal › Journal article › Research › peer-review