Mads Gyrd-Hansen

Research activity per year

CV

Research Experience

2008-
Post. Doc. at Biotech Research & Innovation Centre, Copenhagen, DK

2006-2008
Post. Doc. at The Institute of Cancer Research, London, UK

2005-2006
Post. Doc. at the Danish Cancer Society, Copenhagen, DK

2004- 2005
Research assistant at the Danish Cancer Society, Copenhagen, DK

Primary fields of research

Ubiquitin-mediated signalling
Inhibitor of Apoptosis proteins
Survival signalling in cancer cells

Current research

Regulation of ubiquitin-mediated IkappaB kinase (IKK) signalling by Inhibitor of Apoptosis proteins

Fields of interest

Biological function of non-degradative ubiquitin modifications in signal transduction pathways, epigenetic regulation of cellular programming and disease

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

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21 Journal article
2 Review

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
Nachbur, U., Stafford, C. A., Bankovacki, A., Zhan, Y., Lindqvist, L. M., Fiil, B. K., Khakham, Y., Ko, H.-J., Sandow, J. J., Falk, H., Holien, J. K., Chau, D., Hildebrand, J., Vince, J. E., Sharp, P. P., Webb, A. I., Jackman, K. A., Mühlen, S., Kennedy, C. L. & Lowes, K. N. & 8 others, Murphy, J. M., Gyrd-Hansen, M., Parker, M. W., Hartland, E. L., Lew, A. M., Huang, D. C. S., Lessene, G. & Silke, J., 17 Mar 2015, In: Nature Communications. 6, 13 p., 6442.
Research output: Contribution to journal › Journal article › Research › peer-review
61 Citations (Scopus)
Met1-linked Ubiquitination in Immune Signalling
Fiil, B. K. & Gyrd-Hansen, M., 1 Oct 2014, In: F E B S Journal. 81, 19, p. 4337-50 14 p.
Research output: Contribution to journal › Review › peer-review
41 Citations (Scopus)
Molecular basis and regulation of OTULIN-LUBAC interaction
Elliott, P. R., Al-Saoudi, S. V., Marco-Casanova, P., Fiil, B. K., Keusekotten, K., Mailand, N., Freund, S. M. V., Gyrd-Hansen, M. & Komander, D., 8 May 2014, In: Molecular Cell. 54, 3, p. 335-348 14 p.
Research output: Contribution to journal › Journal article › Research › peer-review
108 Citations (Scopus)

1638 Downloads (Pure)
XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation
Yabal, M., Müller, N., Adler, H., Knies, N., Groß, C. J., Damgaard, R. B., Kanegane, H., Ringelhan, M., Kaufmann, T., Heikenwälder, M., Strasser, A., Groß, O., Ruland, J., Peschel, C., Gyrd-Hansen, M. & Jost, P. J., 26 Jun 2014, In: Cell Reports. 7, 6, p. 1796-1808
Research output: Contribution to journal › Journal article › Research › peer-review
147 Citations (Scopus)
Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling
Damgaard, R. B., Fiil, B. K., Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, S., Jost, P. J., Ehl, S., Mailand, N. & Gyrd-Hansen, M., Aug 2013, In: E M B O Journal. 5, p. 1278-1295 18 p.
Research output: Contribution to journal › Journal article › Research › peer-review
96 Citations (Scopus)
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing met1-linked polyubiquitin
Keusekotten, K., Elliott, P. R., Kulathu, Y., Wauer, T., Hospenthal, M. K., Komander, D., Glockner, L., Krappmann, D., Fiil, B. K., Damgaard, R. B., Gyrd-Hansen, M. & Hofmann, K., 6 Jun 2013, In: Cell. 153, 6, p. 1312-1326 15 p.
Research output: Contribution to journal › Journal article › Research › peer-review
259 Citations (Scopus)
OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling
Fiil, B. K., Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, S., Mailand, N., Choudhary, C. R., Komander, D. & Gyrd-Hansen, M., 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.
Research output: Contribution to journal › Journal article › Research › peer-review
144 Citations (Scopus)
X-linked inhibitor of apoptosis (XIAP) deficiency: The spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis
Speckmann, C., Lehmberg, K., Albert, M. H., Damgaard, R. B., Fritsch, M., Gyrd-Hansen, M., Rensing-Ehl, A., Vraetz, T., Grimbacher, B., Salzer, U., Fuchs, I., Ufheil, H., Belohradsky, B. H., Hassan, A., Cale, C. M., Elawad, M., Strahm, B., Schibli, S., Lauten, M. & Kohl, M. & 10 others, Meerpohl, J. J., Rodeck, B., Kolb, R., Eberl, W., Soerensen, J., von Bernuth, H., Lorenz, M., Schwarz, K.-U., zur Stadt, U. & Ehl, S., 1 Oct 2013, In: Clinical Immunology. 149, 1, p. 133-141 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
104 Citations (Scopus)