Short presentation

The research of my laboratory is focused on the spatio-temporal organization and regulation of homologous recombination (HR) and its role in maintaining genome integrity. We take a cell biological and genetic approach to study HR in the yeast Saccharomyces cerevisiae and in vertebrate cell lines. Particular areas of interest are regulation of chromatin structure during HR, post-translational modification of HR proteins and the molecular architecture of HR complexes in living cells. We are particularly interested in understanding molecular mechanisms relevant to cancer predisposition, neurological disorders and premature ageing syndromes, and in utilizing genetic recombination as a tool to generate combinatorial genetic libraries for biopharmaceutical applications.

For more information visit http://www1.bio.ku.dk/english/research/fg/transkription/

CV

Education

25/10/2000     

Ph.D. degree, Department of Molecular and Structural Biology, Aarhus University, Denmark. Field: Science.

Thesis: The molecular mechanism of type 1B topoisomerases and the catalytic inhibitor camptothecin.

1996-2000     

Graduate studies, Aarhus University, Department of Molecular and Structural Biology, Denmark.

Project: The catalytic mechanism of topoisomerase I and the action of topoisomerase I directed drugs.

1992-1996     

Undergraduate studies at the Department of Molecular and Structural Biology, Aarhus University, Denmark.

Professional / Work Experience

2014- 

Professor in Genome Integrity, Department of Biology, University of Copenhagen

2004-2014     

Associate Professor, Department of Biology, University of Copenhagen, Denmark

2000-2004        

Post doctoral fellow, Department of Genetics and Development, Columbia University, New York, USA

Grants and awards

2009                  

European Research Council, Starting Independent Researcher Grant

Managerial experience

2015-                                                                                                                                                    

Vice-head of Department for research, Department of Biology, University of Copenhagen.

2010-2015                                                                                                                                            

Head of Section. I headed the Section of Functional Genomics at the Department of Biology, University of Copenhagen.