Research output per year
Research output per year
Personal profile
Primary fields of research
Jiri Lukas studies protein pathways that orchestrate spatial and temporal dynamics of chromosomes during the mammalian cell cycle and after DNA damage, with an emphasis on how are these mechanisms subverted in cancer and other diseases associated with unstable genomes. His long-term interests include high-content microscopy screens for genome caretakers and real-time imaging of signaling and repair proteins.
Current research
Recent discoveries from Jiri’s lab include:
• Ubiquitin-driven signalling pathways that barcode chromatin near the DNA lesions to assemble repair and signaling proteins
• Heritability of chromosomal lesions generated on unreplicated DNA during mitosis
• The concept of rate imitation of nodal signaling components as a mechanism to confine repair reactions and posttranslational chromatin modifications to damaged loci in the genome
CV
Jiri Lukas
Current position
May 2012–:
Executive director, Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen
Previous positions
2005-2012:
Director and head of research, Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
1993-2005:
Senior scientist and group leader, Danish Cancer Society, Copenhagen, Denmark
1992-1993:
Differentiation Program (Giulio Draetta lab), EMBL, Heidelberg, Germany.
Research topic: cell cycle regulation, mechanisms of cancer
1991-1992:
Researcher, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
1990, 1991:
Department of Biochemistry (Paul Nurse lab), Oxford, UK.
Research topic: cell cycle regulation
1990-1991:
Researcher, Masaryk Institute of Oncology, Brno, Czech Republic
Education
1987-1990:
PhD in Zoology, Institute of Systematic and Ecological Biology, Brno, Czech Republic
1981-1986:
D.V.M. in Veterinary Medicine, Veterinary University, Brno, Czech Republic
Research awards
2016: Fernström Foundation Grand Nordic Prize
2014: Leopold Griffuel Prize
2014: Elected member of the European Academy of Cancer Sciences
2012: Elected member of the Royal Danish Academy of Sciences and Letters
2010: Danish Society for Cancer Research Award
2008: Danish Cancer Society Senior Research Prize
2005: Honorary member of the Learned Society of the Czech Republic
2003: G. J. Mendel Honorary Medal
2003: Novo Nordisk Foundation Prize
2002: Alfred Benzons Foundation Prize
2002: Elected EMBO Member
1995: Young Danish Cancer Researcher Prize
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Faculty of Health and Medical Sciences
- Protein signaling
- Chromosome dynamics
- Cell cycle
- DNA damage
- Replication stress
- Chromatin modifications
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- 12 Similar Profiles
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53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage
Spies, J., Lukas, C., Somyajit, K., Rask, M.-B., Lukas, J. & Neelsen, K. J., 1 Apr 2019, In: Nature Cell Biology. 21, p. 487-497Research output: Contribution to journal › Journal article › Research › peer-review
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Stabilization of chromatin topology safeguards genome integrity
Ochs, F., Karemore, G., Miron, E., Brown, J., Sedlackova, H., Rask, M.-B., Lampe, M., Buckle, V., Schermelleh, L., Lukas, J. & Lukas, C., 24 Oct 2019, In: Nature. 574, 7779, p. 571-574 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy
Bennetzen, M. V., Kosar, M., Bunkenborg, J., Payne, M. R., Bartkova, J., Lindström, M. S., Lukas, J., Andersen, J. S., Bartek, J. & Larsen, D. H., 2 Sept 2018, In: Cell Cycle. 17, 17, p. 2146-2163Research output: Contribution to journal › Journal article › Research › peer-review
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DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Gupta, R., Somyajit, K., Narita, T., Maskey, E., Stanlie, A., Kremer, M., Typas, D., Lammers, M., Mailand, N., Nussenzweig, A., Lukas, J. & Choudhary, C., 3 May 2018, In: Cell. 173, 4, p. 972-988Research output: Contribution to journal › Journal article › Research › peer-review
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Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N. N., Glytsou, C., Pateras, I. S., Swain, U., Souliotis, V. L., Georgakilas, A. G., Geacintov, N., Scorrano, L., Lukas, C., Lukas, J., Livneh, Z., Lygerou, Z., Chowdhury, D., Sørensen, C. S. & Bartek, J. & 1 others, , 2018, In: Genome Biology (Online Edition). 19, p. 1-18 37.Research output: Contribution to journal › Journal article › Research › peer-review
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Redox-sensitive alteration of replisome architecture safeguards genome integrity
Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, F., Rask, M.-B., Choudhary, C. & Lukas, J., 10 Nov 2017, In: Science. 358, 6364, p. 797-802 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Replication Catastrophe: When a Checkpoint Fails because of Exhaustion
Toledo, L., Neelsen, K. J. & Lukas, J., 15 Jun 2017, In: Molecular Cell. 66, 6, p. 735-749 15 p.Research output: Contribution to journal › Review › peer-review
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53BP1 fosters fidelity of homology-directed DNA repair
Ochs, F., Somyajit, K., Altmeyer, M., Rask, M.-B. D., Lukas, J. & Lukas, C., 1 Aug 2016, In: Nature Structural and Molecular Biology. 23, 8, p. 714-21 8 p.Research output: Contribution to journal › Journal article › Research › peer-review