Kenneth Thermann Kongstad

2019

¹⁹F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by ¹⁹F NMR

Christensen, M. V., Kongstad, K. T., Sondergaard, T. E., Stærk, D., Nielsen, H. M., Franzyk, H. & Wimmer, R., Apr 2019, In: Journal of Biomolecular N M R. 73, p. 167-182

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora: High-resolution inhibition profiling and PTP1B inhibitory activity

Zhao, Y., Kjaerulff, L., Kongstad, K. T., Heskes, A. M., Møller, B. L. & Stærk, D., Oct 2019, In: Phytochemistry. 166, p. 1-8 112054.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Antidiabetic constituents of Dendrobium officinale as determined by high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition combined with HPLC-PDA-HRMS-SPE-NMR analysis.

Chu, C., Li, T., Pedersen, H. A., Kongstad, K. T., Yan, J. & Stærk, D., Jun 2019, In: Phytochemistry Letters. 31, p. 47-52

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Combined magnetic ligand fishing and high-resolution inhibition profiling for identification of α-glucosidase inhibitory ligands: A new screening approach based on complementary inhibition and affinity profiles.

Wubshet, S. G., Liu, B., Kongstad, K. T., Böcker, U., Petersen, M. J., Li, T., Wang, J. & Stærk, D., 1 Aug 2019, In: Talanta. 200, p. 279-287

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Developing new 4-PIOL and 4-PHP analogues for photoinactivation of gamma-aminobutyric acid type A receptors

Mortensen, M., Krall, J., Kongstad, K. T., Brygger, B. M., Lenzi, O., Francotte, P., Sørensen, T. E., Nielsen, B., Jensen, A. A., Smart, T. G. & Frølund, B., 2019, In: A C S Chemical Neuroscience. 10, p. 4669-4684 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Developing new 4-PIOL and 4-PHP analogues for photo-inactivation of γ-aminobutyric acid type A receptors

Mortensen, M., Krall, J., Kongstad, K. T., Brygger, B. M., Lenzi, O., Francotte, P., Sørensen, T. E., Nielsen, B., Jensen, A. A., Smart, T. G. & Frølund, B., 20 Nov 2019, In: ACS Chemical Neuroscience.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

Krall, J., Bavo, F., Falk-Petersen, C. B., Jensen, C. H., Nielsen, J. O., Tian, Y., Anglani, V., Kongstad, K. T., Piilgaard, L., Nielsen, B., Gloriam, D. E., Kehler, J., Jensen, A. A., Harpsøe, K., Wellendorph, P. & Frølund, B., 14 Mar 2019, In: Journal of Medicinal Chemistry. 62, 5, p. 2798-2813

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

Giraudo, A., Krall, J., Bavo, F., Nielsen, B., Kongstad, K. T., Rolando, B., De Blasio, R., Gloriam, D. E., Löffler, R., Thiesen, L., Harpsøe, K., Frydenvang, K., Boschi, D., Wellendorph, P., Lolli, M. L., Jensen, A. A. & Frølund, B., 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans.

Papathanasiou, T., Springborg, A., Kongstad, K. T., Stærk, D., Møller, K., Taylor, B. K., Lund, T. M. & Werner, M. U., Aug 2019, In: British Journal of Anaesthesia. 123, p. e204-e214

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Identification of α-glucosidase inhibitors in Machilus litseifolia by combined use of high-resolution α-glucosidase inhibition profiling and HPLC-PDA-HRMS-SPE-NMR

Li, T., Kongstad, K. T. & Stærk, D., 22 Feb 2019, In: Journal of Natural Products. 82, p. 249-258

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae

Hansen, A. M., Bonke, G., Hogendorf, W. F. J., Björkling, F., Nielsen, J., Kongstad, K. T., Zabicka, D., Tomczak, M., Urbas, M., Nielsen, P. E. & Franzyk, H., 15 Apr 2019, In: European Journal of Medicinal Chemistry. 168, p. 134-145 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Potential of Myrtus communis Linn. as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic triterpenoids and phloroglucinol derivatives

Liang, C., Stærk, D. & Kongstad, K. T., 2019, (Accepted/In press) In: Journal of Functional Foods.

Research output: Contribution to journal › Journal article › Research › peer-review

Simultaneous quantification of high-dose naloxone and naloxone-3-β-D-glucuronide in human plasma by UHPLC-MS/MS

Kongstad, K. T., Papathanasiou, T., Springborg, A., Lund, T. M., Werner, M. U. & Stærk, D., Feb 2019, In: Bioanalysis. 11, p. 165-173

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Unraveling the complexity of complex mixtures by combining high-resolution pharmacological, analytical and spectroscopic techniques: Antidiabetic constituents in Chinese medicinal plants

Zhao, Y., Kongstad, K. T., Liu, Y., He, C. & Stærk, D., 2019, In: Faraday Discussions. 218, p. 202-218

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

2018

4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric gamma-aminobutyric acid receptor binding site

Alessandro, G., Krall, J., Nielsen, B., Sørensen, T. E., Kongstad, K. T., Barbara, R., Donatella, B., Frølund, B. & Lolli, M. L., 5 Oct 2018, In: European Journal of Medicinal Chemistry. 158, p. 311-321 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

Brazilian insulin plant as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of antidiabetic compounds in Myrcia rubella Cambess

Lima, R. D. C. L., Kato, L., Kongstad, K. T. & Stærk, D., Jun 2018, In: Journal of Functional Foods. 45, p. 444-451

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Heterologous production of the widely used natural food colorant carminic acid in Aspergillus nidulans

Frandsen, R. J. N., Khorsand-Jamal, P., Kongstad, K. T., Nafisi, M., Kannangara, R. M., Stærk, D., Okkels, F. T., Binderup, K., Madsen, B., Møller, B. L., Thrane, U. & Mortensen, U. H., 1 Dec 2018, In: Scientific Reports. 8, p. 1-10 10 p., 12853.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

82 Downloads (Pure)

High-resolution PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Miconia albicans

Lima, R. D. C. L., Kongstad, K. T., Kato, L., José das Silva, M., Franzyk, H. & Stærk, D., 2018, In: Molecules. 23, 7, 13 p., 1755.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

37 Downloads (Pure)

On the biosynthetic origin of carminic acid

Rasmussen, S. A., Kongstad, K. T., Khorsand-Jamal, P., Kannangara, R. M., Nafisi, M., Van Dam, A., Bennedsen, M., Madsen, B., Okkels, F. T., Gotfredsen, C. H., Stærk, D., Thrane, U., Mortensen, U. H., Larsen, T. O. & Frandsen, R. J. N., May 2018, In: Insect Biochemistry and Molecular Biology. 96, p. 51-61 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

66 Downloads (Pure)

Quadruple high-resolution α-glucosidase/α-amylase/PTP1B/radical scavenging profiling combined with high-performance liquid chromatography – high-resolution mass spectrometry – solid-phase extraction – nuclear magnetic resonance spectroscopy for identification of antidiabetic constituents in crude root bark of Morus alba L.

Zhao, Y., Kongstad, K. T., Jäger, A. K., Nielsen, J. & Stærk, D., 29 Jun 2018, In: Journal of Chromatography A. 1556, p. 55-63

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Recreational drug use at a major music festival: trend analysis of anonymised pooled urine

Hoegberg, L., Christiansen, C., Søe, J. L., Telving, R., Andreasen, M. F., Stærk, D., Christrup, L. L. & Kongstad, K. T., 3 Apr 2018, In: Clinical Toxicology. 56, p. 245-255 1360496.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

2017

Advancing HPLC-PDA-HRMS-SPE-NMR analysis of coumarins in Coleonema album by use of orthogonal reversed-phase C₁₈ and pentafluorophenyl separations

Lima, R. D. C. L., Gramsbergen, S., Van Staden, J., Jäger, A. K., Kongstad, K. T. & Stærk, D., 28 Apr 2017, In: Journal of Natural Products. 80, 4, p. 1020-1027

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa

Kannangara, R. M., Siukstaite, L., Borch-Jensen, J., Madsen, B., Kongstad, K. T., Stærk, D., Bennedsen, M., Okkels, F. T., Rasmussen, S. A., Larsen, T. O., Frandsen, R. J. N. & Møller, B. L., 1 Dec 2017, In: Nature Communications. 8, 12 p., 1987.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

70 Downloads (Pure)

Characterization of antileishmanial compounds from Lawsonia inermis leaves using semi-high resolution antileishmanial profiling combined with HPLC-HRMS-SPE-NMR

Iqbal, K., Iqbal, J., Stærk, D. & Kongstad, K. T., 31 May 2017, In: Frontiers in Pharmacology. 8, 7 p., 337.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

74 Downloads (Pure)

Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs

Krall, J., Jensen, C. H., Bavo, F., Falk-Petersen, C. B., Haugaard, A. S., Vogensen, S. B., Tian, Y., Nittegaard-Nielsen, M., Sigurdardóttir, S. B., Kehler, J., Kongstad, K. T., Gloriam, D. E., Clausen, R. P., Harpsøe, K., Wellendorph, P. & Frølund, B., 9 Nov 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 9022-9039 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Potential of Polygonum cuspidatum root as an antidiabetic food: Dual high-resolution α-glucosidase and PTP1B inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic constituents

Zhao, Y., Chen, M. X., Kongstad, K. T., Jäger, A. K. & Stærk, D., 7 Jun 2017, In: Journal of Agricultural and Food Chemistry. 65, p. 4421-4427

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

Synthesis of C-glucosylated octaketide anthraquinones in Nicotiana benthamiana using a multispecies-based biosynthetic pathway

Andersen-Ranberg, J., Kongstad, K. T., Nafisi, M., Stærk, D., Okkels, F. T., Mortensen, U. H., Møller, B. L., Frandsen, R. J. N. & Kannangara, R. M., 5 Oct 2017, In: ChemBioChem. 18, 19, p. 1893-1897 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

2016

Accelerating drug lead discovery from nature by high-resolution bioactivity profiling combined with HPLC-HRMS-SPE-NMR

Kongstad, K. T., Nyberg, N. T., Wubshet, S. G. & Staerk, D., Dec 2016, In: Planta Medica. 81, S 01

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Characterization of midazolam metabolism in locusts: The role of CYP3A4-like enzyme in the formation of 1'-OH and 4-OH midazolam

Olsen, L. R., Gabel-Jensen, C., Wubshet, S. G., Kongstad, K. T., Janfelt, C., Badolo, L. & Hansen, S. H., 1 Feb 2016, In: Xenobiotica. 46, 2, p. 99–107 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Edible seaweed as future functional food: Identification of α-glucosidase inhibitors by combined use of high-resolution α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR

Liu, B., Kongstad, K. T., Wiese, S., Jäger, A. K. & Stærk, D., 15 Jul 2016, In: Food Chemistry. 203, p. 16-22 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

51 Citations (Scopus)

Expanding the landscape of diterpene structural diversity by stereochemically controlled combinatorial biosynthesis

Andersen-Ranberg, J., Kongstad, K. T., Nielsen, M. T., Bjerg Jensen, N., Pateraki, I., Bach, S. S., Hamberger, B., Zerbe, P., Stærk, D., Bohlmann, J., Møller, B. L. & Hamberger, B. R., 5 Feb 2016, In: Angewandte Chemie International Edition. 55, 6, p. 2142-2146 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

94 Citations (Scopus)

479 Downloads (Pure)

High-resolution PTP1B inhibition profiling combined with high-performance liquid chromatography - high-resolution mass spectrometry - solid-phase extraction - nuclear magnetic resonance spectroscopy: Proof-of-concept and antidiabetic constituents in crude extract of Eremophila lucida

Tahtah, Y., Wubshet, S. G., Kongstad, K. T., Heskes, A. M., Pateraki, I., Møller, B. L., Jäger, A. & Stærk, D., 1 Apr 2016, In: Fitoterapia. 110, p. 52-58 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

HPLC-HRMS-SPE-NMR combined with high resolution in vitro screening for natural fungicides

Kongstad, K. T., Wubshet, S. G., Kjellerup, L., Winther, A. & Staerk, D., Dec 2016, In: Planta Medica. 82, S 01

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

HPLC-HRMS-SPE-NMR for accelerated identification of compounds in complex plant extracts: New coumarine derivatives from Coleonema album (Thunb.) Bartl. & Wendl

de Cássia Lemos Lima, R., Gramsbergen, S. M., Van Staden, J., Jäger, A. K., Kongstad, K. T. & Stærk, D., Dec 2016, In: Planta Medica. 82, S 01

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

HPLC-SPE-NMR for combinatorial biosynthetic investigations – expanding the landscape of diterpene structural diversity

Kongstad, K. T., Andersen-Ranberg, J., Hamberger, B. R. & Stærk, D., 2016. 1 p.

Research output: Contribution to conference › Poster › Research

110 Downloads (Pure)

Identification of PTP1B and α-glucosidase inhibitory serrulatanes from Eremophila spp. by combined use of dual high-resolution PTP1B and α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR

Wubshet, S. G., Tahtah, Y., Heskes, A. M., Kongstad, K. T., Pateraki, I., Hamberger, B. R., Møller, B. L. & Stærk, D., 22 Apr 2016, In: Journal of Natural Products. 79, 4, p. 1063-1072 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

Ligand-fishing and bioactivity-correlated metabolomics for accelerated discovery of antidiabetic drug leads

Nyberg, N. T., Wubshet, S. G., Kongstad, K. T. & Staerk, D., Dec 2016, In: Planta Medica. 82, S 01

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

The α-glucosidase and PTP1B inhibitory effect of 45 medicinal plants extracts

Liu, B., Kongstad, K. T., Jäger, A. K. & Staerk, D., Dec 2016, In: Planta Medica. 81, S 01, p. 1 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

2015

Combined use of high-resolution α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR for investigation of antidiabetic principles in crude plant extracts

Kongstad, K. T., Özdemir, C., Barzak, A., Wubshet, S. G. & Stærk, D., 5 Feb 2015, In: Journal of Agricultural and Food Chemistry. 63, 8, p. 2257-2263 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

Dual High-Resolution α-Glucosidase and Radical Scavenging Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of Minor and Major Constituents Directly from the Crude Extract of Pueraria lobata

Liu, B., Kongstad, K. T., Qinglei, S., Nyberg, N., Jäger, A. & Stærk, D., 27 Feb 2015, In: Journal of Natural Products. 78, 2, p. 294–300 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

Flipped Learning in Organic Chemistry for Life Sciences – Experiences and Considerations

Kongstad, K. T., 24 Aug 2015, Pedagogical Projects 2014. Vol. 7. p. 125-147 (Improving University Science Teaching and Learning; No. 1-2, Vol. 7).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

Fungal plasma membrane H⁺-ATPase inhibitory activity of o-hydroxybenzylated flavanones and chalcones from Uvaria chamae P. Beauv

Kongstad, K. T., Wubshet, S. G., Kjellerup, L., winther, A-M. L. & Stærk, D., 26 Jun 2015, In: Fitoterapia. 105, p. 102-106 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

High-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of bioactive constituents in crude extract of Pueraria lobata

Liu, B., Kongstad, K. T., Nyberg, N., Qinglei, S., Jäger, A. K. & Stærk, D., 26 Aug 2015.

Research output: Contribution to conference › Poster › Research

720 Downloads (Pure)

High-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of bioactive constituents in crude extract of Pueraria lobata

Liu, B., Kongstad, K. T., Nyberg, N., Qinglei, S., Jäger, A. & Stærk, D., 2015.

Research output: Contribution to conference › Poster › Research

760 Downloads (Pure)

High-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of bioactive constituents in crude extract of Pueraria lobata

Liu, B., Kongstad, K. T., Nyberg, N. T., Sun, Q., Jager, A. K. & Staerk, D., Nov 2015, In: Planta Medica. 81, 16, p. 1437-1437

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Identification of Fungal Plasma Membrane H⁺-ATPase Inhibitors in Lecaniodiscus cupanioides by HPLC-HRMS-SPE-NMR

Straadt, I. K., Kongstad, K. T. & Stærk, D., 2015.

Research output: Contribution to conference › Poster › Research

676 Downloads (Pure)

Triple aldose reductase/α-glucosidase/radical scavenging high-resolution profiling combined with high-performance liquid chromatography – high-resolution mass spectrometry – solid-phase extraction – nuclear magnetic resonance spectroscopy for identification of antidiabetic constituents in crude extract of Radix Scutellariae

Tahtah, Y., Kongstad, K. T., Wubshet, S. G., Nyberg, N., Jønsson, L. H., Jäger, A. K., Qinglei, S. & Stærk, D., 2015, In: Journal of Chromatography A. 1408, p. 125-132 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

2014

5-(Piperidin-4-yl)-3-Hydroxypyrazole: A Novel Scaffold for Probing the Orthosteric γ-Aminobutyric Acid Type A Receptor Binding Site

Krall, J., Kongstad, K. T., Nielsen, B., Sørensen, T. E., Balle, T., Jensen, A. A. & Frølund, B., 1 Nov 2014, In: ChemMedChem. 9, 11, p. 2475-2485 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

High-resolution screening combined with HPLC–HRMS–SPE–NMR for identification of fungal plasma membrane H⁺-ATPase inhibitors from plants

Kongstad, K., Wubshet, S. G., Johannesen, A., Kjellerup, L., winther, A-M. L., Jäger, A. & Stærk, D., 18 Jun 2014, In: Journal of Agricultural and Food Chemistry. 62, 24, p. 5595-5602 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

High-resolution α-amylase assay combined with high-performance liquid chromatography−solid-phase extraction−nuclear magnetic resonance spectroscopy for expedited identification of α-amylase inhibitors – proof of concept and α-amylase inhibitor in cinnamon.

Okutan, L., Kongstad, K. T., Jäger, A. & Stærk, D., 26 Nov 2014, In: Journal of Agricultural and Food Chemistry. 62, 47, p. 11465-11471 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

44 Citations (Scopus)

Kenneth Thermann Kongstad

Research output

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