Research output per year
Research output per year
Personal profile
CV
Education
August 2008: Ph.D. (Analytical Chemistry), Department of Chemistry, University of Copenhagen.
February 2005: Master of Physics and Chemistry, University of Southern Denmark, Odense, Denmark.
May 2002: Bachelor of Chemistry, University of Southern Denmark, Odense, Denmark.
Scientific career
September 2012 - : Associate professor, Department of Pharmacy, University of Copenhagen.
September 2008 – August 2012: Assistant professor, Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen.
September 2009 – February 2010: Visiting researcher in Professor Bernhard Spengler’s research group, Justus-Liebig Universität Giessen, Germany.
May 2005 – August 2008: Ph.D. student, Department of Chemistry, University of Copenhagen.
November 2006 - June 2007: Visiting Ph.D. student in Professor R. Graham Cooks' research group, Purdue University, USA.
September 2002 - December 2004: Teaching assistant, Department of Chemistry, University of Southern Denmark, Odense, Denmark.
July - August 2001: Research scholar, MIC, Technical University of Denmark.
Teaching
Instrumental analytical chemistry / Pharmaceutical analytical chemistry
Mass Spectrometry Coupled to Separation Techniques in Bioanalytical Chemistry
Research
Mass spectrometry, specifically mass spectrometry imaging, surface analysis, instrumental development, ionization techniques and application of mass spectrometry imaging in plant science, drug delivery and pharmacology.
Primary fields of research
I am working with instrumental development of mass spectrometry for use in pharmaceutical analysis. In particular, the work comprises idevelopment and application of techniques for imaging of chemical compounds in biological samples by means of mass spectrometry (mass spectrometry imaging, MSI). More specifically, I am working with the two techniques Desorption Electrospray Ionization (DESI) MSI og Matrix Assisted Laser Desorption Ionization (MALDI)-MSI.
For MALDI-MSI the group has a special MALDI instrument, which by means of sophisticated laser optics and an excellent Orbitrap mass spectrometer enables imaging of biological samples with a very high detail level and very accurate identification of chemical compounds in the sample.
Current research
- development and application of mass spectrometry imaging (MSI), including DESI-MSI and high resolution MALDI-MSI
- application of DESI-MSI for imaging the distribution of drug and metabolites in laboratory animals
- application of high resolution MALDI-MSI in drug delivery studies of the penetration of drugs across various biological membranes
- application of DESI and MALDI-MSI for studies of natural product in plant materials
Knowledge of languages
Danish: Mother tongue
English: Fluent
German: Good
French: Good
Teaching
- indledende kemi samt uorganisk kemi, laboratorieøvelser
- instrumentel analytisk kemi, laboratorieøvelser
- massespektrometri, forelæsninger
Fingerprint
Dive into the research topics where Christian Janfelt is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 6 Similar Profiles
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Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging
Hendel, K. K., Bagger, C., Olesen, U. H., Janfelt, C., Hansen, S. H., Haedersdal, M. & Lerche, C. M., 1 Jan 2019, In: Drug Delivery. 26, 1, p. 244-251 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Visualization of the penetration modifying mechanism of laurocapram by Mass Spectrometry Imaging in buccal drug delivery
Handler, A. M., Marxen, E., Jacobsen, J. & Janfelt, C., 15 Jan 2019, In: European Journal of Pharmaceutical Sciences. 127, p. 276-281 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Buccal delivery of small molecules - Impact of levulinic acid, oleic acid, sodium dodecyl sulfate and hypotonicity on ex vivo permeability and spatial distribution in mucosa
Hansen, S. E., Marxen, E., Janfelt, C. & Jacobsen, J., Dec 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 133, p. 250-257Research output: Contribution to journal › Journal article › Research › peer-review
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Delivery of amitriptyline by intravenous and intraperitoneal administration compared in the same animal by whole-body mass spectrometry imaging of a stable isotope labelled drug substance in mice
Morineau, L., Jacobsen, S. C., Kleberg, K., Hansen, H. S. & Janfelt, C., 2 Dec 2018, In: Expert Opinion on Drug Delivery. 15, 12, p. 1157-1163Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging
Marxen, E., Jin, L., Jacobsen, J., Janfelt, C., Hyrup, B. & Nicolazzo, J. A., 1 Mar 2018, In: Pharmaceutical Research. 35, 3, 12 p., 70.Research output: Contribution to journal › Journal article › Research › peer-review
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MALDI imaging of enzymatic degradation of glycerides by lipase on textile surface
Hall-Andersen, J., Kaasgaard, S. G. & Janfelt, C., Mar 2018, In: Chemistry and Physics of Lipids. 211, p. 100-106Research output: Contribution to journal › Journal article › Research › peer-review
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Permeability Barriers for Nicotine and Mannitol in Porcine Buccal. Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging
Marxen, E., Jacobsen, J., Hyrup, B. & Janfelt, C., 5 Feb 2018, In: Molecular Pharmaceutics. 15, 2, p. 519-526Research output: Contribution to journal › Journal article › Research › peer-review
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The intracellular localization of the vanillin biosynthetic machinery in pods of Vanilla planifolia
Gallage, N. J., Jørgensen, K., Janfelt, C., Nielsen, A. J. Z., Naake, T., Dunski, E., Dalsten, L., Grisoni, M. & Møller, B. L., 1 Feb 2018, In: Plant and Cell Physiology. 59, 2, p. 304-318 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Activities
- 1 Lecture and oral contribution
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Direct and indirect imaging of secondary metabolites and enzymatic reactions in plant material by Desorption Electrospray Ionization
Janfelt, C. (Lecturer)
7 Jun 2012Activity: Talk or presentation types › Lecture and oral contribution