Research output per year
Research output per year
Personal profile
Primary fields of research
The research interests are centered around the DNA mimic PNA (peptide nucleic acid), and the chemical biology and medicinal chemistry properties and applications of derivatives of this molecule. This includes drug discovery (antisense antibiotics, muscular dystrophy, cystic fibrosis), gene targeting and antisense principles in general and cellular and in vivo delivery and administration of biopharmaceuticals. Additional interests cover origin of life prebiotic systems and the effects of oxidative stress on cellular RNA.
Current research
- Discovery of PNA and peptide based antibiotics against resistant Gram-negative bacterial infections
- Quorum sensing inhibitors as cystic fibrosis drugs
- Antisense drugs for Duchenne muscular dystrophy
- Antisense drug delivery and in vivo administration
Keywords
- Faculty of Health and Medical Sciences
- Gene targeting
- PNA
- RNA interference
- Drug delivery
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Dive into the research topics where Peter E. Nielsen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 6 Similar Profiles
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Cooperative Cellular Uptake and Activity of Octaarginine Antisense Peptide Nucleic acid (PNA) Conjugates
Ghavami, M., Shiraishi, T. & Nielsen, P. E., Oct 2019, In: Biomolecules. 9, 10, 554.Research output: Contribution to journal › Journal article › Research › peer-review
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Downregulation of TdT Expression through Splicing Modulation by Antisense Peptide Nucleic Acid (PNA)
Montazersaheb, S., Kazemi, M., Nabat, E., Nielsen, P. E. & Hejazi, M. S., 2019, In: Current Pharmaceutical Biotechnology. 20, 2, p. 168-178 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae
Hansen, A. M., Bonke, G., Hogendorf, W. F. J., Björkling, F., Nielsen, J., Kongstad, K. T., Zabicka, D., Tomczak, M., Urbas, M., Nielsen, P. E. & Franzyk, H., 15 Apr 2019, In: European Journal of Medicinal Chemistry. 168, p. 134-145 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Optimization of lung infection model with carbapenemase producing Klebsiella pneumoniae ST258 (KPC-2) for intranasal treatment in neutropenic NMRI mice
Goncalves Cavaco, L. M., Hjortkjær, C. B., Rasmussen, C., Nielsen, P. E. & Lundberg, C. V., 17 Apr 2019.Research output: Contribution to conference › Poster › Research › peer-review
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PNA length restriction of antibacterial activity of peptide-PNA conjugates in Escherichia coli through effects of the inner membrane
Goltermann, L., Yavari, N., Zhang, M., Ghosal, A. & Nielsen, P. E., 2019, In: Frontiers in Microbiology. 10, MAY, 8 p., 1032.Research output: Contribution to journal › Journal article › Research › peer-review
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Effective photo-enhancement of cellular activity of fluorophore-octaarginine antisense PNA conjugates correlates with singlet oxygen formation, endosomal escape and chromophore lipophilicity
Yarani, R., Shiraishi, T. & Nielsen, P. E., 1 Dec 2018, In: Scientific Reports. 8, 11 p., 638.Research output: Contribution to journal › Journal article › Research › peer-review
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An antisense peptide nucleic acid against Pseudomonas aeruginosa inhibiting bacterial-induced inflammatory responses in the cystic fibrosis IB3-1 cellular model system
Montagner, G., Bezzerri, V., Cabrini, G., Fabbri, E., Borgatti, M., Lampronti, I., Finotti, A., Nielsen, P. E. & Gambari, R., 1 Jun 2017, In: International Journal of Biological Macromolecules. 99, p. 492-498 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antisense PNA antibiotics against multiresistant Gram-negative bacteria
Nielsen, P. E., Björkling, F. & Franzyk, H., 2017, In: International Journal of Molecular Medicine. 40, Suppl. 1, p. S22 1 p., Abstract 169.Research output: Contribution to journal › Conference abstract in journal › Research
Activities
- 1 Editor of Series
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Humana Press - Springer Verlag (Publisher)
Nielsen, P. E. (Editor)
2014Activity: Publication peer-review and editorial work types › Editor of Series › Research