Research output per year
Research output per year
Personal profile
Current research
PhD project: Pharmacological characterization of membrane transporters for γ-hydroxybutyric acid (GHB)
GHB is known as the drug of abuse Fantasy, but is also a clinically used drug for treatment of narcolepsy and the compound is present endogenously in the brain. My PhD project focuses on characterizing different membrane transporters for GHB – primarily in regards to synaptic transport as well as transport across the blood-brain barrier. The work is carried out in Associate Professor Petrine Wellendorph’s laboratory and is focused around the field of molecular pharmacology.
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Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters
Giraudo, A., Krall, J., Bavo, F., Nielsen, B., Kongstad, K. T., Rolando, B., De Blasio, R., Gloriam, D. E., Löffler, R., Thiesen, L., Harpsøe, K., Frydenvang, K., Boschi, D., Wellendorph, P., Lolli, M. L., Jensen, A. A. & Frølund, B., 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809Research output: Contribution to journal › Journal article › Research › peer-review
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GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice
Lie, M. E., Gowing, E. K., Johansen, N. B., Dalby, N. O., Thiesen, L., Wellendorph, P. & Clarkson, A. N., 1 Jan 2019, In: Journal of Cerebral Blood Flow and Metabolism. 15 p., 271678X17744123.Research output: Contribution to journal › Journal article › Research › peer-review
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Lack of evidence for synaptic high-affinity γ-hydroxybutyric acid (GHB) transport in rat brain synaptosomes and 11 Na+ -dependent SLC neurotransmitter transporters
Thiesen, L., Frølund, B. & Wellendorph, P., Apr 2019, In: Journal of Neurochemistry. 149, 2, p. 195-210 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacological Characterization of [3H]ATPCA as a Substrate for Studying the Functional Role of the Betaine/GABA Transporter 1 and the Creatine Transporter
Al-Khawaja, A., Haugaard, A. S., Marek, A., Löffler, R., Thiesen, L., Santiveri, M., Damgaard, M., Bundgaard, C., Frølund, B. & Wellendorph, P., 21 Mar 2018, In: A C S Chemical Neuroscience. 9, 3, p. 545–554Research output: Contribution to journal › Journal article › Research › peer-review
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Radiosynthesis and Evaluation of [(11)C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites
Jensen, C. H., Hansen, H. D., Bay, T., Vogensen, S. B., Lehel, S., Thiesen, L., Bundgaard, C., Clausen, R. P., Knudsen, G. M., Herth, M. M., Wellendorph, P. & Frølund, B., 18 Jan 2017, In: A C S Chemical Neuroscience. 8, 1, p. 22-27 6 p.Research output: Contribution to journal › Letter › peer-review
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In vitro and in vivo evidence for active brain uptake of the GHB analogue HOCPCA by the monocarboxylate transporter subtype 1
Thiesen, L., Kehler, J., Clausen, R. P., Frølund, B., Bundgaard, C. & Wellendorph, P., 1 Aug 2015, In: Journal of Pharmacology and Experimental Therapeutics. 354, 2, p. 166-174 9 p.Research output: Contribution to journal › Journal article › Research › peer-review