Research output per year
Research output per year
Personal profile
Primary fields of research
Population PKPD modelling
Current research
Pharmacometrics
We optimise pharmacotherapy and clinical trial designs by characterising pharmacokinetic-pharmacodynamic relationships using mathematical models that identify sources of variability in drug response.
Examples of projects in our group:
•Fixed dose combinations in drug development - Design of Trials for Identifying Optimal Combination Ratios using Advanced Computer Modelling Tools
•Model-based dose finding in clinical drug development
•The development of fixed-dose combinations (FDCs) through improved methodology – regulatory perspective
•Linking rescue medication with pain intensity using PKPD modelling in clinical pain trials
•PK meta-model on morphine and active metabolite based on 22 clinical studies
•PKPD modelling on synergistic effects of gabapentin and morphine
•Modelling on effect of high-dose target-controlled naloxone infusion on pain and hyperalgesia in patients following groin-hernia-repair
•Differences in metabolic activity of CYP enzymes in obese and lean children
Teaching
Pharmacokinetics and Pharmacodynamics on the following courses:
Basic pharmacology, Principles of Pharmacology, Organ-related pharmacology
Elective course in Pharmacokinetics and -dynamics and post graduate MIND courses and PhD course
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Midazolam Pharmacokinetics in Obese and Non-obese Children and Adolescents
Gade, C., Sverrisdóttir, E., Dalhoff, K., Sonne, J., Johansen, M. Ø., Christensen, H. R., Burhenne, J., Mikus, G., Holm, J. C., Lund, T. M. & Holst, H., 1 May 2020, In: Clinical Pharmacokinetics.Research output: Contribution to journal › Journal article › Research › peer-review
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Body of evidence and approaches applied in the clinical development programme of fixed-dose combinations in the European Union from 2010 to 2016
Nøhr-Nielsen, A., De Bruin, M. L., Thomsen, M., Pipper, C. B., Lange, T., Bjerrum, O. J. & Lund, T. M., Aug 2019, In: British Journal of Clinical Pharmacology. 85, 8, p. 1829-1840 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dose Finding in the Clinical Development of 60 US Food and Drug Administration-Approved Drugs Compared With Learning vs. Confirming Recommendations
Lyauk, Y. K., Jonker, D. M. & Lund, T. M., 1 Sept 2019, In: Clinical and Translational Science.Research output: Contribution to journal › Journal article › Research › peer-review
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High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans.
Papathanasiou, T., Springborg, A., Kongstad, K. T., Stærk, D., Møller, K., Taylor, B. K., Lund, T. M. & Werner, M. U., Aug 2019, In: British Journal of Anaesthesia. 123, p. e204-e214Research output: Contribution to journal › Journal article › Research › peer-review
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Optimizing Dose-Finding Studies for Drug Combinations Based on Exposure-Response Models
Papathanasiou, T., Strathe, A., Overgaard, R. V., Lund, T. M. & Hooker, A. C., 1 Sept 2019, In: The AAPS Journal. 21, 5, p. 95Research output: Contribution to journal › Journal article › Research › peer-review
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Simultaneous quantification of high-dose naloxone and naloxone-3-β-D-glucuronide in human plasma by UHPLC-MS/MS
Kongstad, K. T., Papathanasiou, T., Springborg, A., Lund, T. M., Werner, M. U. & Stærk, D., Feb 2019, In: Bioanalysis. 11, p. 165-173Research output: Contribution to journal › Journal article › Research › peer-review
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Feasibility of Exposure-Response Analyses for Clinical Dose-Ranging Studies of Drug Combinations
Papathanasiou, T., Strathe, A., Hooker, A. C., Lund, T. M. & Overgaard, R. V., 1 May 2018, In: The AAPS Journal. 20, 13 p., 64.Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of opioid consumption in clinical trials: a simulation based analysis of power of four approaches
Juul, R. V., Nyberg, J., Kreilgaard, M., Christrup, L. L., Simonsson, U. S. H. & Lund, T. M., 1 Aug 2017, In: Journal of Pharmacokinetics and Pharmacodynamics. 44, 4, p. 325-333 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Organizer and chairman for Symposium: The role of genotypes in precision medicine
Trine Meldgaard Lund (Participant)
20 Nov 2018Activity: Participating in or organising an event types › Organisation of and participation in conference
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Organizer of Symposium for Danish Pharmaceutical Society: Optimal Design and Analysis of Clinical Trials
Trine Meldgaard Lund (Participant)
9 Nov 2017Activity: Participating in or organising an event types › Organisation of and participation in conference
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Co-organizer of symposium for Danish Society of Clinical Chemical Pharmacology: Therapeutic Drug Monitoring in the Future
Trine Meldgaard Lund (Participant)
8 Nov 2017Activity: Participating in or organising an event types › Organisation of and participation in conference
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Co-organizer of Workshop at Annual Meeting for Danish Society for Pharmacology: Drug toxicity and overdose (Vitamin D)
Trine Meldgaard Lund (Participant)
18 Jan 2017Activity: Participating in or organising an event types › Organisation of and participation in conference
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Co-organizer of symposium for Danish Clinical Chemical Society: Clinical study design and statistical considerations
Trine Meldgaard Lund (Participant)
28 Nov 2016Activity: Participating in or organising an event types › Organisation of and participation in conference
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Co-organizer of Workshop at Annual Meeting for Danish Society for Pharmacology: Therapeutic Drug Management in psychiatric patients
Trine Meldgaard Lund (Participant)
20 Jan 2016Activity: Participating in or organising an event types › Organisation of and participation in conference
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Lecture: Population PKPD Modelling in Children
Trine Meldgaard Lund (Lecturer)
28 Nov 2015Activity: Talk or presentation types › Lecture and oral contribution
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Co-organizer of symposium for Danish Society for Clinical Chemical Pharmacology: Development of biologics - Pharmaceutical, clinical and analytical challenges
Trine Meldgaard Lund (Participant)
29 Oct 2015Activity: Participating in or organising an event types › Organisation of and participation in conference