Research output per year
Research output per year
Personal profile
Primary fields of research
Population PKPD modelling
Current research
Pharmacometrics
We optimise pharmacotherapy and clinical trial designs by characterising pharmacokinetic-pharmacodynamic relationships using mathematical models that identify sources of variability in drug response.
Examples of projects in our group:
•Fixed dose combinations in drug development - Design of Trials for Identifying Optimal Combination Ratios using Advanced Computer Modelling Tools
•Model-based dose finding in clinical drug development
•The development of fixed-dose combinations (FDCs) through improved methodology – regulatory perspective
•Linking rescue medication with pain intensity using PKPD modelling in clinical pain trials
•PK meta-model on morphine and active metabolite based on 22 clinical studies
•PKPD modelling on synergistic effects of gabapentin and morphine
•Modelling on effect of high-dose target-controlled naloxone infusion on pain and hyperalgesia in patients following groin-hernia-repair
•Differences in metabolic activity of CYP enzymes in obese and lean children
Teaching
Pharmacokinetics and Pharmacodynamics on the following courses:
Basic pharmacology, Principles of Pharmacology, Organ-related pharmacology
Elective course in Pharmacokinetics and -dynamics and post graduate MIND courses and PhD course
Fingerprint
Dive into the research topics where Trine Meldgaard Lund is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 6 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Midazolam Pharmacokinetics in Obese and Non-obese Children and Adolescents
Gade, C., Sverrisdóttir, E., Dalhoff, K., Sonne, J., Johansen, M. Ø., Christensen, H. R., Burhenne, J., Mikus, G., Holm, J. C., Lund, T. M. & Holst, H., 1 May 2020, In: Clinical Pharmacokinetics.Research output: Contribution to journal › Journal article › Research › peer-review
-
Body of evidence and approaches applied in the clinical development programme of fixed-dose combinations in the European Union from 2010 to 2016
Nøhr-Nielsen, A., De Bruin, M. L., Thomsen, M., Pipper, C. B., Lange, T., Bjerrum, O. J. & Lund, T. M., Aug 2019, In: British Journal of Clinical Pharmacology. 85, 8, p. 1829-1840 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
-
Dose Finding in the Clinical Development of 60 US Food and Drug Administration-Approved Drugs Compared With Learning vs. Confirming Recommendations
Lyauk, Y. K., Jonker, D. M. & Lund, T. M., 1 Sept 2019, In: Clinical and Translational Science.Research output: Contribution to journal › Journal article › Research › peer-review
-
High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans.
Papathanasiou, T., Springborg, A., Kongstad, K. T., Stærk, D., Møller, K., Taylor, B. K., Lund, T. M. & Werner, M. U., Aug 2019, In: British Journal of Anaesthesia. 123, p. e204-e214Research output: Contribution to journal › Journal article › Research › peer-review
-
Optimizing Dose-Finding Studies for Drug Combinations Based on Exposure-Response Models
Papathanasiou, T., Strathe, A., Overgaard, R. V., Lund, T. M. & Hooker, A. C., 1 Sept 2019, In: The AAPS Journal. 21, 5, p. 95Research output: Contribution to journal › Journal article › Research › peer-review
-
Simultaneous quantification of high-dose naloxone and naloxone-3-β-D-glucuronide in human plasma by UHPLC-MS/MS
Kongstad, K. T., Papathanasiou, T., Springborg, A., Lund, T. M., Werner, M. U. & Stærk, D., Feb 2019, In: Bioanalysis. 11, p. 165-173Research output: Contribution to journal › Journal article › Research › peer-review
-
Feasibility of Exposure-Response Analyses for Clinical Dose-Ranging Studies of Drug Combinations
Papathanasiou, T., Strathe, A., Hooker, A. C., Lund, T. M. & Overgaard, R. V., 1 May 2018, In: The AAPS Journal. 20, 13 p., 64.Research output: Contribution to journal › Journal article › Research › peer-review
-
Analysis of opioid consumption in clinical trials: a simulation based analysis of power of four approaches
Juul, R. V., Nyberg, J., Kreilgaard, M., Christrup, L. L., Simonsson, U. S. H. & Lund, T. M., 1 Aug 2017, In: Journal of Pharmacokinetics and Pharmacodynamics. 44, 4, p. 325-333 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
-
Organizer and chairman for Symposium: The role of genotypes in precision medicine
Lund, T. M. (Participant)
20 Nov 2018Activity: Participating in or organising an event types › Organisation of and participation in conference
-
Organizer of Symposium for Danish Pharmaceutical Society: Optimal Design and Analysis of Clinical Trials
Lund, T. M. (Participant)
9 Nov 2017Activity: Participating in or organising an event types › Organisation of and participation in conference
-
Co-organizer of symposium for Danish Society of Clinical Chemical Pharmacology: Therapeutic Drug Monitoring in the Future
Lund, T. M. (Participant)
8 Nov 2017Activity: Participating in or organising an event types › Organisation of and participation in conference
-
Co-organizer of Workshop at Annual Meeting for Danish Society for Pharmacology: Drug toxicity and overdose (Vitamin D)
Lund, T. M. (Participant)
18 Jan 2017Activity: Participating in or organising an event types › Organisation of and participation in conference
-
Co-organizer of symposium for Danish Clinical Chemical Society: Clinical study design and statistical considerations
Lund, T. M. (Participant)
28 Nov 2016Activity: Participating in or organising an event types › Organisation of and participation in conference
-
Co-organizer of Workshop at Annual Meeting for Danish Society for Pharmacology: Therapeutic Drug Management in psychiatric patients
Lund, T. M. (Participant)
20 Jan 2016Activity: Participating in or organising an event types › Organisation of and participation in conference
-
Lecture: Population PKPD Modelling in Children
Lund, T. M. (Lecturer)
28 Nov 2015Activity: Talk or presentation types › Lecture and oral contribution
-
Co-organizer of symposium for Danish Society for Clinical Chemical Pharmacology: Development of biologics - Pharmaceutical, clinical and analytical challenges
Lund, T. M. (Participant)
29 Oct 2015Activity: Participating in or organising an event types › Organisation of and participation in conference