Kasper Harpsoe

Kasper Harpsøe

Ph.D. and M.Sc. Pharm.

20072019

Research activity per year

Personal profile

CV

Current position:

09/2019 - : Academic Staff, Department of Drug Design and Pharmacology, Faculty of Health and Medical Scineces

Education:

2006: Ph.D., The Danish University of Pharmaceutical Sciences
Title: Computational Studies on Allosteric Modulations of Ionotropic Glutamate Receptors
2001: Master of Science in pharmacy (Cand. Pharm.), The Royal Danish School of Pharmacy
Masters thesis title: Evaluation of MultiSelect and MultiScore - An Evaluation of New Procedures for Predicting Binding Conformation and Binding Affinity

Previous employments:

01/2014 - 08/2015 : Post doc, Department of Drug Design and Pharmacology, Faculty of Health and Medical Scineces

03/2012 - 12/2013: Post doc, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Scineces

11/2011 – 02/2012: Postdoc, Faculty of Pharmaceutical Sciences, University of Copenhagen

12/2007 - 06/2011: Postdoc, Faculty of Pharmaceutical Sciences, University of Copenhagen

07/2007 – 11/2007: Scientific Assistant, Faculty of Pharmaceutical Sciences, University of Copenhagen

07/2006 – 06/2007: Research Scientist (Post Doc.), Arpida A/S, Department of Structural Chemistry

05/2006 – 06/2006: Scientific Assistant, The Danish University of Pharmaceutical Sciences 

05/2003 – 04/2006: Ph.D. Student, The Danish University of Pharmaceutical Sciences (including three months traineeship at Schrödinger Inc. New York)

02/2002 – 04/2003: Clinical Research Associate, Quintiles AB

11/2001 – 01/2002: Pharmacist (temporary position), The Danish Medicines Agency, Department of Clinical Trials.

Research expertises:

- Binding site identification and characterization
- Docking and binding pose evaluation
- Protein-ligand interactions 
- Conformational analysis 
- Structure-based ligand design
- QSAR
- Sequence analysis
- Homology modeling
- Molecular dynamics
- Prediction of protein-ligand binding energy
- Quantum Chemistry calculations

International experience:

2005 - Three month as trainee at Schrödinger.
Performed a validation project on Liaison and gained general experience with the Schrödinger molecular modeling software suite; especially with the extra options and setting available through the command line utilities.

2008 - Two weeks stay with the Carlson research group at University of Michigan.
Gained hands-on experience with setting up Molecular dynamics calculations of large protein-ligand complexes.

 

Primary fields of research

Computational chemistry and molecular modeling in drug design - especially within the target areas of GPCRs, G proteins and ligand-gated ion channels.

Education/Academic qualification

Computational Studies on the Allosteric Modulation of AMPA Receptors

1 May 200330 Apr 2006

Award Date: 23 Aug 2006

Masters thesis title: Evaluation of MultiSelect and MultiScore - An Evaluation of New Procedures for Predicting Binding Conformation and Binding Affinity

1 Sept 199511 Jul 2001

Award Date: 11 Jul 2001

Keywords

  • Faculty of Health and Medical Sciences
  • Molecular Modelling
  • Computational Chemistry
  • Cheminformatics
  • GPCRs
  • Cys-loop receptors

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