Simon Holst Bekker-Jensen

Research output

Research output per year 2006 2012 2013 2015 2016 2019

• 51 Journal article
• 3 Letter
• 3 Review
• 1 Comment/debate

Research output per year

Research output per year

Search results

• 2019

  Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2

  Trulley, P., Snieckute, G., Bekker-Jensen, D., Menon, M. B., Freund, R., Kotlyarov, A., Olsen, J. V., Diaz-Muñoz, M. D., Turner, M., Bekker-Jensen, S., Gaestel, M. & Tiedje, C., 4 Jun 2019, In: Cell Reports. 27, 10, p. 2859-2870.e6 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Heat-Shock Proteins 100%
  • Protein Kinases 88%
  • Protein Isoforms 77%
  • Protein 39%
  • Serine 30%
  2 Citations (Scopus)

  25 Downloads (Pure)

• GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling

  Tollenaere, M. A. X., Tiedje, C., Rasmussen, S., Nielsen, J. C., Vind, A. C., Blasius, M., Batth, T. S., Mailand, N., Olsen, J. V., Gaestel, M. & Bekker-Jensen, S., 26 Mar 2019, In: Cell Reports. 26, 13, p. 3511-3521.e4 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Tristetraprolin 100%
  • Messenger RNA 34%
  • RNA-Binding Proteins 30%
  • RNA Sequencing 25%
  • Proline 18%
  13 Citations (Scopus)

  5 Downloads (Pure)

• Protein aggregation capture on microparticles enables multi-purpose proteomics sample preparation

  Batth, T. S., Tollenaere, M. A. X., Rüther, P. L., Gonzalez-Franquesa, A., Prabhakar, B. S., Bekker-Jensen, S. H., Deshmukh, A. S. & Olsen, J. V., May 2019, In: Molecular and Cellular Proteomics. 18, 5, p. 1027-1035

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sample Preparation Method 100%
  • Proteome 86%
  • Heterogeneity 76%
  • Proteomics 76%
  • Sample Preparation 69%
  31 Citations (Scopus)

  58 Downloads (Pure)

• Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

  Holdgaard, S. G., Cianfanelli, V., Pupo, E., Lambrughi, M., Lubas, M., Nielsen, J. C., Eibes, S., Maiani, E., Harder, L. M., Wesch, N., Foged, M. M., Maeda, K., Nazio, F., de la Ballina, L. R., Dötsch, V., Brech, A., Frankel, L. B., Jäättelä, M., Locatelli, F., Barisic, M., & 8 othersAndersen, J. S., Bekker-Jensen, S., Lund, A. H., Rogov, V. V., Papaleo, E., Lanzetti, L., De Zio, D. & Cecconi, F., 1 Dec 2019, In: Nature Communications. 10, 1, p. 1-19 19 p., 4176.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • mitosis 100%
  • Centrosome 89%
  • integrity 75%
  • Mitosis 70%
  • Autophagy 69%
  18 Citations (Scopus)

  13 Downloads (Pure)

• The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3

  Ronkina, N., Shushakova, N., Tiedje, C., Yakovleva, T., Tollenaere, M. A. X., Scott, A., Batth, T. S., Olsen, J. V., Helmke, A., Bekker-Jensen, S. H., Clark, A. R., Kotlyarov, A. & Gaestel, M., 2019, In: Journal of immunology (Baltimore, Md. : 1950). 203, 8, p. 2291-2300 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • MAP-kinase-activated kinase 3 100%
  • MAP-kinase-activated kinase 2 86%
  • Tristetraprolin 84%
  • Phosphorylation 35%
  • Cytokines 31%
  11 Citations (Scopus)
• 2018

  Alternative translation initiation generates a functionally distinct isoform of the stress-activated kinase MK2

  Trulley, P., Snieckute, G., Bekker-Jensen, D. B., Menon, M. B., Freund, R., Kotlyarov, A., Olsen, J. V., Diaz-Muñoz, M. D., Turner, M., Bekker-Jensen, S. H., Gaestel, M. & Tiedje, C., 2018, In: bioRxiv. 46 p.

  Research output: Contribution to journal › Journal article › Research

  • Protein Isoforms 100%
  • Phosphotransferases 95%
  • GC Rich Sequence 23%
  • G-Quadruplexes 22%
  • RNA Helicases 21%

• Osmotic Stress Blocks Mobility and Dynamic Regulation of Centriolar Satellites

  Nielsen, J. C., Nordgaard, C., Tollenaere, M. A. X. & Bekker-Jensen, S., Jul 2018, In: Cells. 7, 7, 20 p., 65.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Centrosome 100%
  • Biological Role 99%
  • Osmotic Pressure 95%
  • Inducer 92%
  • Compound Mobility 60%
  36 Downloads (Pure)

• p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

  Borisova, M. E., Voigt, A., Tollenaere, M. A. X., Sahu, S. K., Juretschke, T., Kreim, N., Mailand, N., Choudhary, C., Bekker-Jensen, S., Akutsu, M., Wagner, S. A. & Beli, P., 1 Dec 2018, In: Nature Communications. 9, p. 1-16 16 p., 1017.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • phosphorylation 100%
  • metabolism 88%
  • Ultraviolet Rays 73%
  • ultraviolet radiation 70%
  • deoxyribonucleic acid 64%
  22 Citations (Scopus)

  98 Downloads (Pure)
• 2016

  Activation of the ATR kinase by the RPA-binding protein ETAA1

  Haahr, P., Hoffmann, S., Tollenaere, M. A. X., Ho, T., Toledo Lazaro, L. I., Mann, M., Bekker-Jensen, S., Räschle, M. & Mailand, N., 27 Oct 2016, In: Nature Cell Biology. 18, 11, p. 1196–1207

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ewing's Sarcoma 100%
  • Neoplasm Antigens 87%
  • Carrier Proteins 69%
  • Phosphotransferases 63%
  • human ETAA1 protein 51%
  106 Citations (Scopus)

  1235 Downloads (Pure)

• H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

  Saredi, G., Huang, H., Hammond, C. M., Alabert, C., Bekker-Jensen, S., Forne, I., Reverón-Gómez, N., Foster, B. M., Mlejnkova, L., Bartke, T., Cejka, P., Mailand, N., Imhof, A., Patel, D. J. & Groth, A., 30 Jun 2016, In: Nature. 534, 7609, p. 714-8 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Histones 100%
  • DNA Repair 98%
  • Chromatin 94%
  • DNA Replication 71%
  • Ankyrin Repeat 51%
  84 Citations (Scopus)

• Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

  Schwertman, P., Bekker-Jensen, S. & Mailand, N., 1 Jun 2016, In: Nature Reviews. Molecular Cell Biology. 17, 6, p. 379-94 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Double-Stranded DNA Breaks 100%
  • Ubiquitin 87%
  • Genomic Instability 31%
  • Maintenance 20%
  • Genome 19%
  167 Citations (Scopus)

• SCAI promotes DNA double-strand break repair in distinct chromosomal contexts

  Hansen, R. K., Mund, A., Poulsen, S. L., Sandoval, M., Klement, K., Tsouroula, K., Tollenaere, M. A. X., Räschle, M., Soria, R., Offermanns, S., Worzfeld, T., Grosse, R., Brandt, D. T., Rozell, B., Mann, M., Cole, F., Soutoglou, E., Goodarzi, A. A., Daniel, J. A., Mailand, N., & 1 othersBekker-Jensen, S., 1 Dec 2016, In: Nature Cell Biology. 18, 12, p. 1357–1366

  Research output: Contribution to journal › Letter › peer-review

  • Double-Stranded DNA Breaks 100%
  • Chromatin 42%
  • Neoplasms 28%
  • Homologous Recombination 21%
  • Recombinases 13%
  14 Citations (Scopus)

  146 Downloads (Pure)

• SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling

  Airik, R., Schueler, M., Airik, M., Cho, J., Ulanowicz, K. A., Porath, J. D., Hurd, T. W., Bekker-Jensen, S., Schrøder, J. M., Andersen, J. S. & Hildebrandt, F., 2016, In: P L o S One. 11, 5, 19 p., e0156081.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • centrosomes 100%
  • Hedgehogs 97%
  • Erinaceidae 93%
  • Mouse 93%
  • Centrosome 92%
  9 Citations (Scopus)

  100 Downloads (Pure)

• Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO

  Diehl, C., Akke, M., Bekker-Jensen, S., Mailand, N., Streicher, W. & Wikström, M., 10 Jun 2016, In: Journal of Biological Chemistry. 291, 24, p. 12658-12672 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CREB-Binding Protein 100%
  • Epitope 70%
  • Ubiquitin 69%
  • Protein Binding 68%
  • Binding Site 48%
  14 Citations (Scopus)

• TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress

  Hoffmann, S., Smedegaard, S., Nakamura, K., Mortuza, G. B., Räschle, M., Ibañez de Opakua, A., Oka, Y., Feng, Y., Blanco, F. J., Mann, M., Montoya, G., Groth, A., Bekker-Jensen, S. & Mailand, N., 1 Jan 2016, In: The Journal of Cell Biology. 212, 1, p. 63-75

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Genomic Instability 100%
  • Ligases 99%
  • Proliferating Cell Nuclear Antigen 98%
  • Ubiquitin 91%
  • DNA Replication 54%
  41 Citations (Scopus)

  591 Downloads (Pure)
• 2015

  Centriolar satellites: key mediators of centrosome functions

  Tollenaere, M. A. X., Mailand, N. & Bekker-Jensen, S., Jan 2015, In: Cellular and molecular life sciences : CMLS. 73, 1, p. 11-23 13 p.

  Research output: Contribution to journal › Review › peer-review

  • Centrosome 100%
  • Neurogenesis 42%
  • Protein Transport 22%
  • Cues 17%
  • Maintenance 14%
  59 Citations (Scopus)

• Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

  Thorslund, T., Ripplinger, A., Hoffmann, S., Wild, T., Uckelmann, M., Villumsen, B., Narita, T., Sixma, T. K., Choudhary, C. R., Bekker-Jensen, S. & Mailand, N., 19 Nov 2015, In: Nature. 527, 7578, p. 389-93 5 p.

  Research output: Contribution to journal › Letter › peer-review

  • Ubiquitin 100%
  • Histones 93%
  • Ubiquitination 89%
  • DNA Damage 86%
  • Chromatin 58%
  199 Citations (Scopus)

  261 Downloads (Pure)

• Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage

  Gibbs-Seymour, I., Markiewicz, E., Bekker-Jensen, S., Mailand, N. & Hutchison, C. J., 1 Apr 2015, In: Aging Cell. 14, 2, p. 162-9 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lamin Type A 100%
  • DNA Damage 62%
  • Tumor Suppressor p53-Binding Protein 1 17%
  • Tudor Domain 17%
  • Fibroblasts 15%
  31 Citations (Scopus)

• p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1

  Tollenaere, M. A. X., Villumsen, B. H., Blasius, M., Nielsen, J. C., Wagner, S. A., Bartek, J., Beli, P., Mailand, N. & Bekker-Jensen, S., 30 Nov 2015, In: Nature Communications. 6, p. 1-12 12 p., 10075.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Centrosome 100%
  • 14-3-3 Proteins 55%
  • Phosphorylation 55%
  • Effector 43%
  • Cytoplasm 32%
  28 Citations (Scopus)

• Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells

  Bursomanno, S., Beli, P., Khan, A. M., Minocherhomji, S., Wagner, S. A., Bekker-Jensen, S., Mailand, N., Choudhary, C. R., Hickson, I. D. & Liu, Y., Jan 2015, In: DNA Repair. 25, p. 84-96 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteome 100%
  • DNA Replication 96%
  • Sumoylation 64%
  • Aphidicolin 51%
  • Protein 39%
  28 Citations (Scopus)

• Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

  Räschle, M., Smeenk, G., Hansen, R. K., Temu, T., Oka, Y., Hein, M. Y., Nagaraj, N., Long, D. T., Walter, J. C., Hofmann, K., Storchova, Z., Cox, J., Bekker-Jensen, S., Mailand, N. & Mann, M., 1 May 2015, In: Science (New York, N.Y.). 348, 6234, p. 539- 10 p., 1253671.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteomics 100%
  • DNA 60%
  • Chromatin 57%
  • DNA Repair 40%
  • Mass Spectrometry 39%
  95 Citations (Scopus)

  202 Downloads (Pure)

• RNF138 joins the HR team

  Bekker-Jensen, S. & Mailand, N., 1 Nov 2015, In: Nature Cell Biology. 17, 11, p. 1375-7 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Double-Stranded DNA Breaks 100%
  • Ubiquitin-Protein Ligases 49%
  • Homologous Recombination 49%
  • DNA 24%
  2 Citations (Scopus)

• Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway

  Oka, Y., Bekker-Jensen, S. & Mailand, N., 12 May 2015, In: E M B O Journal. 34, p. 1385-1398

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitins 100%
  • Fanconi Anemia 89%
  • DNA Repair 31%
  • Protein 27%
  • Heterodimerization 24%
  9 Citations (Scopus)

• Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

  Gibbs-Seymour, I., Oka, Y., Rajendra, E., Weinert, B. T., Passmore, L. A., Patel, K. J., Olsen, J. V., Choudhary, C. R., Bekker-Jensen, S. & Mailand, N., 8 Jan 2015, In: Molecular Cell. 57, 1, p. 150-64 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Fanconi Anemia 100%
  • Sumoylation 75%
  • Ubiquitin 75%
  • DNA Damage 65%
  • Ligases 40%
  79 Citations (Scopus)
• 2014

  Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response Signaling

  Airik, R., Slaats, G. G., Guo, Z., Weiss, A-C., Khan, N., Ghosh, A., Hurd, T. W., Bekker-Jensen, S., Schrøder, J. M., Elledge, S. J., Andersen, J. S., Kispert, A., Castelli, M., Boletta, A., Giles, R. H. & Hildebrandt, F., 1 Nov 2014, In: Journal of the American Society of Nephrology:JASN. 25, 11, p. 2573-83 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ciliopathies 100%
  • Retinaldehyde 99%
  • DNA Damage 58%
  • Retinal Degeneration 49%
  • Kidney 36%
  40 Citations (Scopus)

• UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells

  Oka, Y., Varmark, H., Vitting-Seerup, K., Beli, P., Waage, J. E., Hakobyan, A., Mistrik, M., Choudhary, C. R., Rohde, M., Bekker-Jensen, S. & Mailand, N., Sept 2014, In: E M B O Reports. 15, 9, p. 956-964 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromatids 100%
  • Cohesion 96%
  • RNA Precursors 89%
  • Ubiquitins 39%
  • Spliceosomes 36%
  26 Citations (Scopus)
• 2013

  A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis

  Villumsen, B. H., Danielsen, J. R., Povlsen, L., Sylvestersen, K. B., Merdes, A., Beli, P., Yang, Y-G., Choudhary, C. R., Nielsen, M. L., Mailand, N. & Bekker-Jensen, S., 27 Nov 2013, In: E M B O Journal. 32, 23, p. 3029-3040

  Research output: Contribution to journal › Journal article › Research › peer-review

  • UV Radiation 100%
  • Displacement 70%
  • Heat 63%
  • Ubiquitination 62%
  • Block Like Crystal 58%
  73 Citations (Scopus)

• ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

  Toledo Lazaro, L. I., Altmeyer, M., Rask, M-B., Lukas, C., Larsen, D. H., Povlsen, L. K., Bekker-Jensen, S., Mailand, N., Bartek, J. & Lukas, J., 21 Nov 2013, In: Cell. 155, 5, p. 1088-1103 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Single-Stranded DNA 100%
  • Cell Nucleus 48%
  • Reduction 42%
  • DNA Damage 41%
  • Hypersensitivity 38%
  420 Citations (Scopus)

• Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

  Damgaard, R. B., Fiil, B. K., Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, S., Jost, P. J., Ehl, S., Mailand, N. & Gyrd-Hansen, M., Aug 2013, In: E M B O Journal. 5, p. 1278-1295 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lymphoproliferative Syndrome, X-Linked, 2 100%
  • Mutation 54%
  • Apoptosis 39%
  • Pattern Recognition 19%
  • Oligomerization 16%
  96 Citations (Scopus)

• OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

  Fiil, B. K., Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, S., Mailand, N., Choudhary, C. R., Komander, D. & Gyrd-Hansen, M., 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Polyubiquitin 100%
  • Ubiquitination 74%
  • Nod2 Signaling Adaptor Protein 66%
  • Ubiquitin 17%
  • Receptors, Tumor Necrosis Factor, Type I 12%
  144 Citations (Scopus)

• Regulation of PCNA-protein interactions for genome stability

  Mailand, N., Gibbs-Seymour, I. & Bekker-Jensen, S., May 2013, In: Nature Reviews. Molecular Cell Biology. 14, 5, p. 269-82 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Genomic Instability 100%
  • Proliferating Cell Nuclear Antigen 98%
  • Nuclear Proteins 94%
  • Proteins 26%
  • Ubiquitination 19%
  225 Citations (Scopus)

• RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

  Poulsen, S. L., Hansen, R. K., Wagner, S. A., van Cuijk, L., van Belle, G. J., Streicher, W., Wikström, M., Choudhary, C. R., Houtsmuller, A. B., Marteijn, J. A., Bekker-Jensen, S. & Mailand, N., 10 Jun 2013, In: Journal of Cell Biology. 201, 6, p. 797-807 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ligases 100%
  • Ubiquitin 91%
  • DNA Damage 79%
  • Ubiquitination 61%
  • Sumoylation 30%
  97 Citations (Scopus)

• The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases

  Mosbech, A., Lukas, C., Bekker-Jensen, S. & Mailand, N., 7 Jun 2013, In: Journal of Biological Chemistry. 288, p. 16579-16587 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Double-Stranded DNA Breaks 100%
  • Ligases 95%
  • Histone 93%
  • Ubiquitin 87%
  • Enzymes 47%
  82 Citations (Scopus)
• 2012

  A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

  Luijsterburg, M. S., Acs, K., Ackermann, L., Wiegant, W. W., Bekker-Jensen, S., Larsen, D. H., Khanna, K. K., van Attikum, H., Mailand, N. & Dantuma, N. P., 30 May 2012, In: E M B O Journal. 31, 11, p. 2511-27 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ligases 100%
  • Histone 97%
  • Ubiquitin 91%
  • Chromatin 80%
  • Chromatin Assembly and Disassembly 80%
  75 Citations (Scopus)

• DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

  Danielsen, J. M. R., Povlsen, L. K., Villumsen, B. H., Streicher, W., Nilsson, J., Wikström, M., Bekker-Jensen, S. & Mailand, N., Apr 2012, In: Journal of Cell Biology. 197, 2, p. 179-87 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sumoylation 100%
  • Zinc Fingers 84%
  • DNA 41%
  • Chromatin 39%
  • Ubiquitination 32%
  91 Citations (Scopus)

• DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

  Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, C., Hartmann-Petersen, R., Lukas, J., Choudhary, C. R., Pocock, R. D. J., Bekker-Jensen, S. & Mailand, N., Nov 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitin 100%
  • DNA Damage 86%
  • Proliferating Cell Nuclear Antigen 80%
  • Anaphase-Promoting Complex-Cyclosome 36%
  • DNA-Directed DNA Polymerase 27%
  120 Citations (Scopus)

• Histone displacement during nucleotide excision repair

  Dinant, C., Bartek, J. & Bekker-Jensen, S., 17 Oct 2012, In: International Journal of Molecular Sciences (Online). 13, 10, p. 13322-13337 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • chromatin 100%
  • nucleotides 96%
  • Nucleotides 95%
  • Histone 82%
  • Histones 72%
  6 Citations (Scopus)

• Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

  Poulsen, M., Lukas, C., Lukas, J., Bekker-Jensen, S. & Mailand, N., Apr 2012, In: Journal of Cell Biology. 197, 2, p. 189-99 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Double-Stranded DNA Breaks 100%
  • Ubiquitin 87%
  • Chromatin 77%
  • Ubiquitination 56%
  • Ubiquitin-Protein Ligases 19%
  80 Citations (Scopus)

• ICLs: a chicken without an egg

  Bekker-Jensen, S. & Mailand, N., Jun 2012, In: Nature Reviews. Molecular Cell Biology. 13, 6, p. 342

  Research output: Contribution to journal › Review › peer-review

• RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells

  Østergaard, V. H., Pentzold, C., Pedersen, R. T., Iosif, S., Alpi, A., Bekker-Jensen, S., Mailand, N. & Lisby, M., 1 Nov 2012, In: D N A Repair. 11, 11, p. 892–905 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Camptothecin 100%
  • Ubiquitination 84%
  • Cell Viability 77%
  • Chickens 75%
  • DNA Damage 67%
  20 Citations (Scopus)

• Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

  Povlsen, L. K., Beli, P., Wagner, S. A., Poulsen, S. L., Sylvestersen, K. B., Poulsen, J. W., Nielsen, M. L., Bekker-Jensen, S., Mailand, N. & Choudhary, C. R., Oct 2012, In: Nature Cell Biology. 14, 10, p. 1089-98 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitination 100%
  • DNA Damage 80%
  • Proliferating Cell Nuclear Antigen 66%
  • DNA Replication 30%
  • DNA-Directed DNA Polymerase 17%
  156 Citations (Scopus)

• The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

  Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W. W-L., Fiil, B. K., Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C., Ruland, J., Bekker-Jensen, S., Mailand, N., Kaufmann, T., Strasser, A., Walczak, H., Silke, J., Jost, P. J. & Gyrd-Hansen, M., 29 Jun 2012, In: Molecular Cell. 46, 6, p. 746-58 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ligases 100%
  • Ubiquitin 91%
  • Innate Immunity 84%
  • Lymphoproliferative Syndrome, X-Linked, 2 80%
  • Apoptosis 55%
  242 Citations (Scopus)

• TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

  Gudjónsson, T., Altmeyer, M. F., Savic, V., Toledo Lazaro, L. I., Dinant, C., Grøfte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, S., Mailand, N., Neumann, B., Heriche, J-K., Shearer, R., Saunders, D., Bartek, J., Lukas, J. & Lukas, C., 17 Aug 2012, In: Cell. 150, 4, p. 697-709 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitination 100%
  • Histone 98%
  • Spreading 97%
  • Chromatin 81%
  • Chromosomes 72%
  204 Citations (Scopus)

• Ubiquitin and the DNA damage response: a new handle on histones

  Bekker-Jensen, S. & Mailand, N., 1 Sept 2012, In: Cell Cycle. 11, 17, p. 3153 1 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review

  2 Citations (Scopus)
• 2011

  53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

  Lukas, C., Savic, V., Bekker-Jensen, S., Doil, C., Neumann, B., Pedersen, R. S., Grøfte, M., Chan, K. L., Hickson, I. D., Bartek, J. & Lukas, J., 1 Mar 2011, In: Nature Cell Biology. 13, 3, p. 243-53 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromosomes 100%
  • Genome 85%
  • Chromatin 74%
  • DNA 70%
  • condensin complexes 67%
  426 Citations (Scopus)

• Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level

  Danielsen, J. M. R., Sylvestersen, K. B., Bekker-Jensen, S., Szklarczyk, D., Poulsen, J. W., Horn, H., Jensen, L. J., Mailand, N. & Nielsen, M. L., 1 Mar 2011, In: Molecular and Cellular Proteomics. 10, 3, p. M110.003590

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitination 100%
  • Lysine 89%
  • Lysine Residue 51%
  • Ubiquitin 34%
  • Modification 25%
  215 Citations (Scopus)

• The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks

  Bekker-Jensen, S. & Mailand, N., 16 Sept 2011, In: FEBS Letters. 585, p. 2914-2919 6 p.

  Research output: Contribution to journal › Review › peer-review

  • Double-Stranded DNA Breaks 100%
  • Ubiquitin 87%
  • Chromatin 77%
  • Protein 36%
  • Genome 29%
  89 Citations (Scopus)
• 2010

  Assembly and function of DNA double-strand break repair foci in mammalian cells

  Bekker-Jensen, S. & Mailand, N., 10 Dec 2010, In: D N A Repair. 9, 12, p. 1219-28 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Double-Stranded DNA Breaks 100%
  • Mammalian Cell 90%
  • Ionizing Radiation 53%
  • Protein 36%
  • DNA Repair 32%
  250 Citations (Scopus)

• HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

  Bekker-Jensen, S., Danielsen, J. M. R., Fugger, K., Gromova, I., Nerstedt, A., Bartek, J., Lukas, J. & Mailand, N., Jan 2010, In: Nature Cell Biology. 12, 1, p. 80-6; sup pp 1-12

  Research output: Contribution to journal › Letter › peer-review

  • Ubiquitin 100%
  • DNA Repair 92%
  • Chromosomes 78%
  • DNA Damage 49%
  • Ligases 31%
  208 Citations (Scopus)
• 2009

  Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

  Carson, C. T., Orazio, N. I., Lee, D. V., Suh, J., Bekker-Jensen, S., Araujo, F. D., Lakdawala, S. S., Lilley, C. E., Bartek, J., Lukas, J. & Weitzman, M. D., 2009, In: EMBO Journal. 28, 6, p. 652-62 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adenoviridae Infections 100%
  • Ataxia Telangiectasia 93%
  • Virus Diseases 54%
  • Immobilization 50%
  • DNA Damage 42%
  76 Citations (Scopus)