RNF138 joins the HR team

Simon Bekker-Jensen; Niels Mailand

doi:10.1038/ncb3262

RNF138 joins the HR team

2 Citations (Scopus)

Abstract

Two studies show that the E3 ubiquitin ligase RNF138 is recruited to DNA double-strand break sites, where it ubiquitylates key repair factors to promote DNA-end resection and homologous recombination. These findings add insights into the multilayered regulatory mechanisms underlying DNA double-strand break repair pathway choice in mammalian cells.

Original language	English
Journal	Nature Cell Biology
Volume	17
Issue number	11
Pages (from-to)	1375-7
Number of pages	3
ISSN	1465-7392
DOIs	https://doi.org/10.1038/ncb3262
Publication status	Published - 1 Nov 2015

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RNF138 joins the HR team

Abstract

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