Regulation of PCNA-protein interactions for genome stability

Niels Mailand; Ian Gibbs-Seymour; Simon Bekker-Jensen

doi:10.1038/nrm3562

Regulation of PCNA-protein interactions for genome stability

Niels Mailand, Ian Gibbs-Seymour, Simon Bekker-Jensen

225 Citations (Scopus)

Abstract

Proliferating cell nuclear antigen (PCNA) has a central role in promoting faithful DNA replication, providing a molecular platform that facilitates the myriad protein-protein and protein-DNA interactions that occur at the replication fork. Numerous PCNA-associated proteins compete for binding to a common surface on PCNA; hence these interactions need to be tightly regulated and coordinated to ensure proper chromosome replication and integrity. Control of PCNA-protein interactions is multilayered and involves post-translational modifications, in particular ubiquitylation, accessory factors and regulated degradation of PCNA-associated proteins. This regulatory framework allows cells to maintain a fine-tuned balance between replication fidelity and processivity in response to DNA damage.

Original language	English
Journal	Nature Reviews. Molecular Cell Biology
Volume	14
Issue number	5
Pages (from-to)	269-82
Number of pages	14
ISSN	1471-0072
DOIs	https://doi.org/10.1038/nrm3562
Publication status	Published - May 2013

Access to Document

10.1038/nrm3562

Cite this

@article{32aaf0902def4999bd7808b4c5daaeca,

title = "Regulation of PCNA-protein interactions for genome stability",

abstract = "Proliferating cell nuclear antigen (PCNA) has a central role in promoting faithful DNA replication, providing a molecular platform that facilitates the myriad protein-protein and protein-DNA interactions that occur at the replication fork. Numerous PCNA-associated proteins compete for binding to a common surface on PCNA; hence these interactions need to be tightly regulated and coordinated to ensure proper chromosome replication and integrity. Control of PCNA-protein interactions is multilayered and involves post-translational modifications, in particular ubiquitylation, accessory factors and regulated degradation of PCNA-associated proteins. This regulatory framework allows cells to maintain a fine-tuned balance between replication fidelity and processivity in response to DNA damage.",

author = "Niels Mailand and Ian Gibbs-Seymour and Simon Bekker-Jensen",

year = "2013",

month = may,

doi = "10.1038/nrm3562",

language = "English",

volume = "14",

pages = "269--82",

journal = "Nature Reviews Molecular Cell Biology",

issn = "1471-0072",

publisher = "nature publishing group",

number = "5",

}

TY - JOUR

T1 - Regulation of PCNA-protein interactions for genome stability

AU - Mailand, Niels

AU - Gibbs-Seymour, Ian

AU - Bekker-Jensen, Simon

PY - 2013/5

Y1 - 2013/5

N2 - Proliferating cell nuclear antigen (PCNA) has a central role in promoting faithful DNA replication, providing a molecular platform that facilitates the myriad protein-protein and protein-DNA interactions that occur at the replication fork. Numerous PCNA-associated proteins compete for binding to a common surface on PCNA; hence these interactions need to be tightly regulated and coordinated to ensure proper chromosome replication and integrity. Control of PCNA-protein interactions is multilayered and involves post-translational modifications, in particular ubiquitylation, accessory factors and regulated degradation of PCNA-associated proteins. This regulatory framework allows cells to maintain a fine-tuned balance between replication fidelity and processivity in response to DNA damage.

AB - Proliferating cell nuclear antigen (PCNA) has a central role in promoting faithful DNA replication, providing a molecular platform that facilitates the myriad protein-protein and protein-DNA interactions that occur at the replication fork. Numerous PCNA-associated proteins compete for binding to a common surface on PCNA; hence these interactions need to be tightly regulated and coordinated to ensure proper chromosome replication and integrity. Control of PCNA-protein interactions is multilayered and involves post-translational modifications, in particular ubiquitylation, accessory factors and regulated degradation of PCNA-associated proteins. This regulatory framework allows cells to maintain a fine-tuned balance between replication fidelity and processivity in response to DNA damage.

U2 - 10.1038/nrm3562

DO - 10.1038/nrm3562

M3 - Journal article

C2 - 23594953

SN - 1471-0072

VL - 14

SP - 269

EP - 282

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

IS - 5

ER -

Regulation of PCNA-protein interactions for genome stability

Abstract

Access to Document

Fingerprint

Cite this