Klaus Hansen

2020

Going low to reach high: Small-scale ChIP-seq maps new terrain

Fosslie, M., Manaf, A., Lerdrup, M., Hansen, K., Gilfillan, G. D. & Dahl, J. A., 1 Jan 2020, In: Wiley Interdisciplinary Reviews: Systems Biology and Medicine. p. e1465

Research output: Contribution to journal › Review › peer-review

1 Citation (Scopus)

2019

PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells

Agrawal-Singh, S., Lerdrup, M., Gomes, A-L. R., van de Werken, H. J. G., Johansen, J. V., Andersson, R., Sandelin, A., Helin, K. & Hansen, K., 23 Jan 2019, In: eLife. 8, p. 1-32 32 p., e40364.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

85 Downloads (Pure)

Proteogenomic characterization of patient-derived xenografts highlights the role of REST in neuroendocrine differentiation of castration-resistant prostate cancer

Flores-Morales, A., Bergmann, T. B., Lavallee, C., Batth, T. S., Lin, D., Lerdrup, M., Friis, S., Bartels, A., Kristensen, G., Krzyzanowska, A., Xue, H., Fazli, L., Hansen, K., Røder, M. A., Brasso, K., Moreira, J. M., Bjartell, A., Wang, Y., Olsen, J. V., Collins, C. C., & 1 othersIglesias-Gato, D., 15 Jan 2019, In: Clinical Cancer Research. 25, 2, p. 1-15

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion

Brix, D. M., Tvingsholm, S. A., Hansen, M. B., Clemmensen, K. B., Ohman, T., Siino, V., Lambrughi, M., Hansen, K., Puustinen, P., Gromova, I., James, P., Papaleo, E., Varjosalo, M., Moreira, J., Jäättelä, M. & Kallunki, T., 25 Apr 2019, In: Oncogene. 38, p. 3170-3184

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

2018

Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

Shoaib, M., Walter, D., Gillespie, P. J., Izard, F., Fahrenkrog, B., Lleres, D., Lerdrup, M., Johansen, J. V., Hansen, K., Julien, E., Blow, J. J. & Sørensen, C. S., 2018, In: Nature Communications. 9, 1, p. 1-11 11 p., 3704.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

98 Downloads (Pure)

2017

Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia

Göllner, S., Oellerich, T., Agrawal-Singh, S., Schenk, T., Klein, H-U., Rohde, C., Pabst, C., Sauer, T., Lerdrup, M., Tavor, S., Stölzel, F., Herold, S., Ehninger, G., Köhler, G., Pan, K-T., Urlaub, H., Serve, H., Dugas, M., Spiekermann, K., Vick, B., & 8 othersJeremias, I., Berdel, W. E., Hansen, K., Zelent, A., Wickenhauser, C., Müller, L. P., Thiede, C. & Müller-Tidow, C., 1 Jan 2017, In: Nature Medicine. 23, 1, p. 69-78 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

100 Citations (Scopus)

2016

A High-Density Map for Navigating the Human Polycomb Complexome

Hauri, S., Comoglio, F., Seimiya, M., Gerstung, M., Glatter, T., Hansen, K., Aebersold, R., Paro, R., Gstaiger, M. & Beisel, C., 4 Oct 2016, In: Cell Reports. 17, 2, p. 583-595 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

97 Citations (Scopus)

80 Downloads (Pure)

An interactive environment for agile analysis and visualization of ChIP-sequencing data

Lerdrup, M., Johansen, J. V., Agrawal-Singh, S. & Hansen, K., 5 Apr 2016, In: Nature Structural and Molecular Biology. 23, 4, p. 349-57 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

91 Citations (Scopus)

A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ∆FosB Expression

Feyder, M., Södersten, E., Santini, E., Vialou, V., LaPlant, Q., Watts, E. L., Spigolon, G., Hansen, K., Caboche, J., Nestler, E. J. & Fisone, G., 1 Mar 2016, In: Biological Psychiatry.

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition

Dahl, J. A., Jung, I., Aanes, H., Greggains, G. D., Manaf, A., Lerdrup, M., Li, G., Kuan, S., Li, B., Lee, A. Y., Preissl, S., Jermstad, I., Haugen, M. H., Suganthan, R., Bjørås, M., Hansen, K., Dalen, K. T., Fedorcsak, P., Ren, B. & Klungland, A., 14 Sept 2016, In: Nature. 537, p. 548–552

Research output: Contribution to journal › Letter › peer-review

231 Citations (Scopus)

Differential regulation of the phosphorylation of Trimethyl-lysine27 histone H3 at serine 28 in distinct populations of striatal projection neurons

Bonito-Oliva, A., Södersten, E., Spigolon, G., Hu, X., Hellysaz, A., Falconi, A., Rodrigues Gomes, A. L., Broberger, C., Hansen, K. & Fisone, G., Aug 2016, In: Neuropharmacology. 107, p. 89-99 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

2015

The lncRNA MIR31HG regulates p16(INK4A) expression to modulate senescence

Montes Resano, M., Nielsen, M. M., Maglieri, G., Jacobsen, A., Højfeldt, J., Agrawal-Singh, S., Hansen, K., Helin, K., van de Werken, H. J. G., Pedersen, J. S. & Lund, A. H., 24 Apr 2015, In: Nature Communications. 6, p. 6967

Research output: Contribution to journal › Journal article › Research › peer-review

108 Citations (Scopus)

β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4

Funa, N. S. A., Schachter, K., Lerdrup, M., Ekberg, J., Hess, K., Dietrich, N., Honore, C., Hansen, K. & Semb, T. H., 4 Jun 2015, In: Cell Stem Cell. 16, 6, p. 639-52 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

71 Citations (Scopus)

2014

Dopamine signaling leads to loss of Polycomb repression and aberrant gene activation in experimental parkinsonism

Södersten, E., Feyder, M., Lerdrup, M., Rodrigues Gomes, A. L., Kryh, H., Spigolon, G., Caboche, J., Fisone, G. & Hansen, K., 1 Sept 2014, In: P L o S Genetics. 10, 9, p. e1004574

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

2013

CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression

Egan, C. M., Nyman, U., Skotte, J., Streubel, G., Turner, S., O'Connell, D. J., Rraklli, V., Dolan, M. J., Chadderton, N., Hansen, K., Farrar, G. J., Helin, K., Holmberg, J. & Bracken, A. P., 12 Aug 2013, In: Developmental Cell. 26, 3, p. 223-36 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

67 Citations (Scopus)

DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding

Schoofs, T., Rohde, C., Hebestreit, K., Klein, H-U., Göllner, S., Schulze, I., Lerdrup, M., Dietrich, N., Agrawal-Singh, S., Witten, A., Stoll, M., Lengfelder, E., Hofmann, W-K., Schlenke, P., Büchner, T., Hansen, K., Berdel, W. E., Rosenbauer, F., Dugas, M. & Müller-Tidow, C., 3 Jan 2013, In: Blood. 121, 1, p. 178-87 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

52 Citations (Scopus)

2012

Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene

Agrawal-Singh, S., Isken, F., Agelopoulos, K., Klein, H-U., Thoennissen, N. H., Koehler, G., Hascher, A., Bäumer, N., Berdel, W. E., Thiede, C., Ehninger, G., Becker, A., Schlenke, P., Wang, Y., McClelland, M., Krug, U., Koschmieder, S., Büchner, T., Yu, D-Y., Singh, S. V., & 4 othersHansen, K., Serve, H., Dugas, M. & Müller-Tidow, C., 8 Mar 2012, In: Blood. 119, 10, p. 2346-57 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

67 Citations (Scopus)

REST-mediated recruitment of polycomb repressor complexes in mammalian cells

Dietrich, N., Lerdrup, M., Landt, E., Agrawal-Singh, S., Bak, M., Tommerup, N., Rappsilber, J., Södersten, E. & Hansen, K., Mar 2012, In: P L o S Genetics (Online). 8, 3, p. e1002494

Research output: Contribution to journal › Journal article › Research › peer-review

105 Citations (Scopus)

2010

Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model

Agrawal-Singh, S., Koschmieder, S., Gelsing, S., Stocking, C., Stehling, M., Thiede, C., Thoennissen, N. H., Köhler, G., Valk, P. J. M., Delwel, R., Mills, K., Bäumer, N., Tickenbrock, L., Hansen, K., Berdel, W. E., Müller-Tidow, C. & Serve, H., 3 Jun 2010, In: Blood. 115, 22, p. 4507-16 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Polycomb Group Protein Displacement and Gene Activation through MSK-Dependent H3K27me3S28 Phosphorylation

Gehani, S. S., Agrawal-Singh, S., Dietrich, N., Christophersen, N. S., Helin, K. & Hansen, K., Sept 2010, In: Molecular Cell. 39, 6, p. 886-900 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

138 Citations (Scopus)

2009

Epigenetic inheritance through self-recruitment of the polycomb repressive complex 2

Hansen, K. & Helin, K., 1 Apr 2009, In: Epigenetics. 4, 3, p. 133-8 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

2008

A model for transmission of the H3K27me3 epigenetic mark

Hansen, K. H., Bracken, A. P., Pasini, D., Dietrich, N., Gehani, S. S., Monrad, A., Rappsilber, J., Lerdrup, M. & Helin, K., 2008, In: Nature Cell Biology. 10, 11, p. 1291-300 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

509 Citations (Scopus)

Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.

Pasini, D., Hansen, K. H., Christensen, J., Agger, K., Cloos, P. A. C. & Helin, K., 2008, In: Genes & Development. 22, 10, p. 1345-55 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

243 Citations (Scopus)

Erratum: A model for transmission of the H3K27me3 epigenetic mark (Nature Cell Biology (2008) vol. 10 (1291-1300))

Hansen, K. H., Bracken, A. P., Pasini, D., Dietrich, N., Gehani, S. S., Monrad, A., Rappsilber, J., Lerdrup, M. & Helin, K., 12 Nov 2008, In: Nature Cell Biology. 10, 11

Research output: Contribution to journal › Comment/debate › Research › peer-review

Regulation of Stem Cell Differentiation by Histone Methyltransferases and Demethylases

Pasini, D., Bracken, A. P., Agger, K., Christensen, J. A., Hansen, K., Cloos, P. A. C. & Helin, K., 2008, In: Cold Spring Harbor Symposia on Quantitative Biology. 73, p. 253-63 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

2007

Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.

Dietrich, N., Bracken, A. P., Trinh, E., Schjerling, C. K., Koseki, H., Rappsilber, J., Helin, K. & Hansen, K., 2007, In: EMBO Journal. 26, 6, p. 1637-48 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

147 Citations (Scopus)

Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation.

Hauge, C., Antal, T. L., Hirschberg, D., Doehn, U., Thorup, K., Idrissova, L., Hansen, K., Jensen, O. N., Jørgensen, T. J., Biondi, R. M. & Frödin, M., 2007, In: EMBO Journal. 26, 9, p. 2251-61 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

76 Citations (Scopus)

RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.

Christensen, J., Agger, K., Cloos, P. A. C., Pasini, D., Rose, S., Sennels, L., Rappsilber, J., Hansen, K., Salcini, A. E. & Helin, K., 2007, In: Cell. 128, 6, p. 1063-76 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

390 Citations (Scopus)

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.

Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J-C., Hansen, K. H. & Helin, K., 2007, In: Genes & Development. 21, 5, p. 525-30 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

668 Citations (Scopus)

2006

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.

Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H. & Helin, K., 2006, In: Genes & Development. 20, 9, p. 1123-36 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

942 Citations (Scopus)

Immunoprecipitation of Proteins under Nondenaturing Conditions

Lukas, J., Bartek, J. & Hansen, K., 1 Dec 2006, Cell Biology, Four-Volume Set. Elsevier Science Inc., Vol. 4. p. 253-258 6 p.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

1 Citation (Scopus)

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.

Cloos, P. A. C., Christensen, J., Agger, K., Maiolica, A., Rappsilber, J., Antal, T., Hansen, K. H. & Helin, K., 2006, In: Nature. 442, 7100, p. 307-11 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

566 Citations (Scopus)

2003

Protein phosphatase 2A associates with Rb2/p130 and mediates retinoic acid-induced growth suppression of ovarian carcinoma cells.

Vuocolo, S., Purev, E., Zhang, D., Bartek, J., Hansen, K., Soprano, D. R. & Soprano, K. J., 2003, In: Journal of Biological Chemistry. 278, 43, p. 41881-9 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

2002

Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.

Farkas, T., Hansen, K., Holm, K., Lukas, J. & Bartek, J., 2002, In: Journal of Biological Chemistry. 277, 30, p. 26741-52 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

56 Citations (Scopus)

2001

Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block.

Hansen, K., Farkas, T., Lukas, J., Holm, K., Rönnstrand, L. & Bartek, J., 2001, In: EMBO Journal. 20, 3, p. 422-32 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

80 Citations (Scopus)

2000

Determination of drug effect on tumour cells, host animal toxicity and drug pharmacokinetics in a hollow-fibre model in rats.

Jonsson, E., Friberg, L. E., Karlsson, M. O., Hassan, S. B., Freijs, A., Hansen, K. & Larsson, R., 2000, In: Cancer Chemotherapy and Pharmacology. 46, 6, p. 493-500 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors.

Thullberg, M., Bartkova, J., Khan, S., Hansen, K., Rönnstrand, L., Lukas, J., Strauss, M. & Bartek, J., 2000, In: FEBS Letters. 470, 2, p. 161-6 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

1999

Dissecting functions of the retinoblastoma tumor suppressor and the related pocket proteins by integrating genetic, cell biology, and electrophoretic techniques.

Hansen, K., Lukas, J., Holm, K., Kjerulff, A. A. & Bartek, J., 1999, In: Electrophoresis. 20, 2, p. 372-81 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis.

Rönnstrand, L., Siegbahn, A., Rorsman, C., Johnell, M., Hansen, K. & Heldin, C. H., 1999, In: Journal of Biological Chemistry. 274, 31, p. 22089-94 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

1998

Metastasis-associated Mts1 (S100A4) protein modulates protein kinase C phosphorylation of the heavy chain of nonmuscle myosin

Kriajevska, M., Tarabykina, S., Bronstein, I., Maitland, N., Lomonosov, M., Hansen, K., Georgiev, G. & Lukanidin, E., 17 Apr 1998, In: Journal of Biological Chemistry. 273, 16, p. 9852-9856 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

130 Citations (Scopus)

1997

Association of coatomer proteins with the beta-receptor for platelet-derived growth factor.

Hansen, K., Rönnstrand, L., Rorsman, C., Hellman, U. & Heldin, C. H., 1997, In: Biochemical and Biophysical Research Communications. 235, 3, p. 455-60 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

Lukas, J., Herzinger, T., Hansen, K., Moroni, M. C., Resnitzky, D., Helin, K., Reed, S. I. & Bartek, J., 1997, In: Genes & Development. 11, 11, p. 1479-92 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

316 Citations (Scopus)

PDGF-induced phosphorylation of Tyr28 in the N-terminus of Fyn affects Fyn activation.

Hansen, K., Alonso, G., Courtneidge, S. A., Rönnstrand, L. & Heldin, C. H., 1997, In: Biochemical and Biophysical Research Communications. 241, 2, p. 355-62 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Phosphorylation of a 72-kDa protein in PDGF-stimulated cells which forms complex with c-Crk, c-Fyn and Eps15.

Hansen, K., Rönnstrand, L., Claesson-Welsh, L. & Heldin, C. H., 1997, In: FEBS Letters. 409, 2, p. 195-200 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Serine protein kinase activity associated with rotavirus phosphoprotein NSP5.

Blackhall, J., Fuentes, A., Hansen, K. & Magnusson, G., 1997, In: Journal of Virology. 71, 1, p. 138-44 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

1996

Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.

Hansen, K., Johnell, M., Siegbahn, A., Rorsman, C., Engström, U., Wernstedt, C., Heldin, C. H. & Rönnstrand, L., 1996, In: EMBO Journal. 15, 19, p. 5299-313 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

104 Citations (Scopus)

1994

Direct interaction between Shc and the platelet-derived growth factor beta-receptor.

Yokote, K., Mori, S., Hansen, K., McGlade, J., Pawson, T., Heldin, C. H. & Claesson-Welsh, L., 1994, In: Journal of Biological Chemistry. 269, 21, p. 15337-43 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

135 Citations (Scopus)

1993

Application of two‐dimensional gel analysis to identification and characterization of tyrosine phosphorylated substrates for growth factor receptors

Hansen, K. & Møller, J. V., 1 Jan 1993, In: Electrophoresis. 14, 1, p. 112-126 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

1990

The concentration of ouabain binding sites in biopsies of uterine muscle

Everts, M. E., Skajaa, K. & Hansen, K., 1 Jan 1990, In: Acta Physiologica Scandinavica. 139, 3, p. 503-510 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Klaus Hansen

Research output

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