Regulation of Stem Cell Differentiation by Histone Methyltransferases and Demethylases

TY - JOUR

T1 - Regulation of Stem Cell Differentiation by Histone Methyltransferases and Demethylases

AU - Pasini, D

AU - Bracken, A P

AU - Agger, K

AU - Christensen, Jesper Aagaard

AU - Hansen, Klaus

AU - Cloos, P A C

AU - Helin, K

PY - 2008

Y1 - 2008

N2 - The generation of different cell types from stem cells containing identical genetic information and their organization into tissues and organs during development is a highly complex process that requires defined transcriptional programs. Maintenance of such programs is epigenetically regulated and the factors involved in these processes are often essential for development. The activities required for cell-fate decisions are frequently deregulated in human tumors, and the elucidation of the molecular mechanisms that regulate these processes is therefore important for understanding both developmental processes and tumorigenesis.

AB - The generation of different cell types from stem cells containing identical genetic information and their organization into tissues and organs during development is a highly complex process that requires defined transcriptional programs. Maintenance of such programs is epigenetically regulated and the factors involved in these processes are often essential for development. The activities required for cell-fate decisions are frequently deregulated in human tumors, and the elucidation of the molecular mechanisms that regulate these processes is therefore important for understanding both developmental processes and tumorigenesis.

U2 - 10.1101/sqb.2008.73.009

DO - 10.1101/sqb.2008.73.009

M3 - Journal article

C2 - 19022750

SN - 0091-7451

VL - 73

SP - 253

EP - 263

JO - Cold Spring Harbor Symposia on Quantitative Biology

JF - Cold Spring Harbor Symposia on Quantitative Biology

ER -