@article{c80db2b0532111dd8d9f000ea68e967b,
title = "Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors.",
abstract = "p16(INK4a), p15(INK4b), p18(INK4c) and p19(INK4d) comprise a family of cyclin-dependent kinase inhibitors and tumor suppressors. We report that the INK4 proteins share the ability to arrest cells in G1, and interact with CDK4 or CDK6 with similar avidity. In contrast, only p18 and particularly p19 are phosphorylated in vivo, and each of the human INK4 proteins shows unique expression patterns dependent on cell and tissue type, and differentiation stage. Thus, the INK4 proteins harbor redundant as well as non-overlapping properties, suggesting distinct regulatory modes, and diverse roles for the individual INK4 family members in cell cycle control, cellular differentiation, and multistep oncogenesis.",
author = "M Thullberg and J Bartkova and S Khan and Klaus Hansen and L R{\"o}nnstrand and J Lukas and M Strauss and J Bartek",
note = "Keywords: Binding, Competitive; Carrier Proteins; Cell Cycle Proteins; Cell Differentiation; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p19; Cyclin-Dependent Kinases; Enzyme Inhibitors; G1 Phase; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, p16; Humans; Multigene Family; Organ Specificity; Phosphorylation; Protein Binding; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Teratocarcinoma; Tretinoin; Tumor Cells, Cultured; Tumor Suppressor Proteins",
year = "2000",
language = "English",
volume = "470",
pages = "161--6",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "2",
}