Research output per year
Research output per year
Personal profile
Short presentation
Henrik Semb's research focus on elucidating basic mechanism in morphogenesis and how tissue architecture controls cell lineage commitment by using a combination of in vivo and in vitro genetic and cell biological experimental tools. Pancreas organogenesis in the mouse is used as model. We also use human pluripotent stem cells (hESCs/hiPSCs) as tools to study human pancreatic beta cell development and beta cell dysfunction in vitro as well as a source for transplantable beta cells in type 1 diabetes therapy.
For more information please visit the following webpages:
About Henrik Semb: http://danstem.ku.dk/people/semb_staff/semb/
Semb lab: http://danstem.ku.dk/research1/semb_laboratory/
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Faculty of Health and Medical Sciences
- Human Embryonic Stem Cells
- pancreas
- endoderm
- pluripotency
- Induced Pluripotent Stem Cells (iPSC)
- Diabetes
- beta cells
- Insulin
- cell fate
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Dive into the research topics where Tor Henrik Semb is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Mechanosignalling via integrins directs fate decisions of pancreatic progenitors
Mamidi, A., Prawiro, C., Seymour, P. A., de Lichtenberg, K. H., Jackson, A., Serup, P. & Semb, H., 6 Dec 2018, In: Nature. 564, 7734, p. 114-118 5 p.Research output: Contribution to journal › Letter › peer-review
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Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2+ Human Pancreatic Progenitors
Ameri, J., Borup, R., Prawiro, C., Ramond, C., Schachter, K., Scharfmann, R. & Semb, T. H., 4 Apr 2017, In: Cell Reports. 19, 1, p. 36-49 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity
Löf-Öhlin, Z. M., Nyeng, P., Bechard, M. E., Hess, K., Bankaitis, E., Greiner, T. U., Ameri, J., Wright, C. V. & Semb, H., 1 Nov 2017, In: Nature Cell Biology. 19, 11, p. 1313-1325 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reconstructing human pancreatic differentiation by mapping specific cell populations during development
Ramond, C., Glaser, N., Berthault, C., Ameri, J., Kirkegaard, J. S., Hansson, M., Honoré, C., Semb, T. H. & Scharfmann, R., 2017, In: eLife. 6, 22 p., e27564.Research output: Contribution to journal › Journal article › Research › peer-review
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Method for production of insulin-producing cells
Mamidi, A. & Semb, T. H., 2016, IPC No. WO 2016/170067 A1, Priority date 24 Apr 2015Research output: Patent
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Retinol dehydrogenase-10 regulates pancreas organogenesis and endocrine cell differentiation via paracrine retinoic acid signalling
Arregi, I., Climent, M., Iliev, D., Strasser, J., Gouignard, N., Johansson, J. K., Singh, T., Mazur, M., Semb, H., Artner, I., Minichiello, L. & Pera, E. M., Dec 2016, In: Endocrinology. 157, 12, p. 4615-4631 17 p., en20161745.Research output: Contribution to journal › Journal article › Research › peer-review
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β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4
Funa, N. S. A., Schachter, K., Lerdrup, M., Ekberg, J., Hess, K., Dietrich, N., Honore, C., Hansen, K. & Semb, T. H., 4 Jun 2015, In: Cell Stem Cell. 16, 6, p. 639-52 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cdc42/N-WASP signaling links actin dynamics to pancreatic beta cell delamination and differentiation
Kesavan, G., Lieven, O., Mamidi, A., Ohlin, Z. L., Johansson, J. K., Li, W-C., Lommel, S., Greiner, T. U. & Semb, H., Jan 2014, In: Development. 141, 3, p. 685-696 12 p.Research output: Contribution to journal › Journal article › Research › peer-review