Clara Prats Gavalda

2020

Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men

Dollerup, O. L., Chubanava, S., Agerholm, M., Søndergård, S. D., Altıntaş, A., Møller, A. B., Høyer, K. F., Ringgaard, S., Stødkilde-Jørgensen, H., Lavery, G. G., Barrès, R., Larsen, S., Prats, C., Jessen, N. & Treebak, J. T., 1 Feb 2020, In: The Journal of Physiology.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

2019

ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations

Graae, A.-S., Grarup, N., Ribel-Madsen, R., Lystbæk, S. H., Boesgaard, T., Staiger, H., Fritsche, A., Wellner, N., Sulek, K., Kjølby, M. F., Backe, M. B., Chubanava, S., Prats, C., Serup, A. K. L., Birk, J. B., Dubail, J., Gillberg, L., Vienberg, S. G., Nykjær, A. & Kiens, B. & 10 others, Wojtaszewski, J., Larsen, S., Apte, S. S., Häring, H.-U., Vaag, A., Zethelius, B., Pedersen, O. B., Treebak, J. T., Hansen, T. & Holst, B., 1 Mar 2019, In: Diabetes. 68, 3, p. 502-514

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training

Halling, J. F., Jessen, H., Nøhr-Meldgaard, J., Buch, B. T., Christensen, N. M., Gudiksen, A., Ringholm, S., Neufer, P. D., Prats, C. & Pilegaard, H., Sept 2019, In: American journal of physiology. Endocrinology and metabolism. 317, 3, p. E513-E525

Research output: Contribution to journal › Journal article › Research › peer-review

2018

Obesity leads to impairments in the morphology and organization of human skeletal muscle lipid droplets and mitochondrial networks, which are resolved with gastric bypass surgery-induced improvements in insulin sensitivity

Kristensen, M. D., Petersen, S. M., Møller, K. E., Lund, M. T., Hansen, M., Hansen, C. N., Courraud, J., Helge, J. W., Dela, F. & Prats, C., Dec 2018, In: Acta Physiologica (Print). 224, 4, 15 p., e13100 .

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Perturbations of NAD⁺ salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscle

Andersen, M. A., Dall, M., Jensen, B. A. H., Prats, C., Madsen, S., Basse, A. L., Graae, A.-S., Risis, S., Goldenbaum, J., Quistorff, B., Larsen, S., Vienberg, S. G. & Treebak, J. T., Apr 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 314, 4, p. E377-E395 19 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study

Larsen, S., Vigelsø, A., Dandanell, S., Prats, C., Dela, F. & Helge, J. W., 2018, In: Journal of Diabetes Research. 2018, 7 p., 9257874 .

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

The dynamic life of the glycogen granule

Prats, C., Graham, T. E. & Shearer, J., 11 May 2018, In: Journal of Biological Chemistry. 293, 19, p. 7089-7098

Research output: Contribution to journal › Review › peer-review

47 Citations (Scopus)

2017

Exercise training protects against aging-induced mitochondrial fragmentation in mouse skeletal muscle in a PGC-1α dependent manner

Halling, J. F., Jørgensen, S. R., Olesen, J., Prats Gavalda, C. & Pilegaard, H., 1 Oct 2017, In: Experimental Gerontology. 96, p. 1-6 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

Macrophage Area Content and Phenotype in Hepatic and Adipose Tissue in Patients with Obesity Undergoing Roux-en-Y Gastric Bypass

Kristensen, M. D., Lund, M. T., Hansen, M., Poulsen, S. S., Ploug, T., Dela, F., Helge, J. W. & Prats, C., Nov 2017, In: Obesity. 25, 11, p. 1921-1931 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Raman probing of lipids, proteins, and mitochondria in skeletal myocytes: a case study on obesity

Brazhe, N. A., Nikelshparg, E. I., Prats, C., Dela, F. & Sosnovtseva, O., Sept 2017, In: Journal of Raman Spectroscopy. 48, 9, p. 1158-1165 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Repeated Excessive Exercise Attenuates the Anti-Inflammatory Effects of Exercise in Older Men

Sahl, R. E., Andersen, P. R., Gronbaek, K., Morville, T. H., Rosenkilde, M., Rasmusen, H. K., Poulsen, S. S., Prats, C., Dela, F. & Helge, J. W., 22 Jun 2017, In: Frontiers in Physiology. 8, 6 p., 407.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

65 Downloads (Pure)

2016

Effects of immobilization and aerobic training on proteins related to intramuscular substrate storage and metabolism in young and older men

Vigelsø Hansen, A., Gram, M., Wiuff, C., Hansen, C. N., Prats Gavalda, C., Dela, F. & Helge, J. W., 1 Mar 2016, In: European Journal of Applied Physiology. 116, 3, p. 481-494 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes

Lund, M. T., Kristensen, M. D., Hansen, M., Tveskov, L., Floyd, A. K., Støckel, M., Vainer, B., Poulsen, S. S., Helge, J. W., Prats Gavalda, C. & Dela, F., 1 Aug 2016, In: The Journal of Physiology. 594, 15, p. 4351-4358 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Higher muscle content of perilipin 5 and endothelial lipase protein in trained than untrained middle-aged men

Vigelsø Hansen, A., Prats , C., Ploug, T., Dela, F. & Helge, J. W., 2016, In: Physiological Research. 65, 2, p. 293-302 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate intensity exercise in human skeletal muscle

Vigelsø, A., Gram, M., Dybboe, R., Kuhlman, A. B., Prats Gavalda, C., Greenhaff, P. L., Constantin-Teodosiu, D., Birk, J. B., Wojtaszewski, J., Dela, F. & Helge, J. W., 15 Apr 2016, In: Journal of Physiology. 594, 8, p. 2339-2358 20 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

2015

Three dimensional reconstruction of the human skeletal muscle mitochondrial network as a tool to assess mitochondrial content and structural organization

Dahl, R., Larsen, S., Dohlmann, T. L., Qvortrup, K., Helge, J. W., Dela, F. & Prats Gavalda, C., Jan 2015, In: Acta Physiologica. 213, 1, p. 145-155

Research output: Contribution to journal › Journal article › Research › peer-review

52 Citations (Scopus)

Ultrastructural myocardial changes in seven cats with spontaneous hypertrophic cardiomyopathy

Christiansen, L. B., Prats Gavalda, C., Hyttel, P. & Koch, J., 1 Dec 2015, In: Journal of Veterinary Cardiology. 17 , Suppl. 1, p. S220-S232 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

428 Downloads (Pure)

2014

Akt and Rac1 signalling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance

Sylow, L., Kleinert, M., Pehmøller, C., Prats Gavalda, C., Chiu, T. T., Klip, A., Richter, E. & Jensen, T. E., 2014, In: Cellular Signalling. 26, 2, p. 323-331 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

85 Citations (Scopus)

Exercise interventions to prevent and manage type 2 diabetes: physiological mechanisms

Dela, F., Prats Gavalda, C. & Helge, J. W., 2014, In: Medicine and Sport Science. 60, p. 36-47 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

2013

Adipocyte size and cellular expression of caveolar proteins analyzed by confocal microscopy.

Hulstrøm, V., Prats Gavalda, C. & Vinten, J., 15 Jun 2013, In: American Journal of Physiology: Cell Physiology. 304, 12, p. C1168-75 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

An optimized histochemical method to assess skeletal muscle glycogen and lipid stores reveals two metabolically distinct populations of type I muscle fibers

Prats Gavalda, C., Gomez-Cabello, A., Nordby, P., Andersen, J. L., Helge, J. W., Dela, F., Baba, O. & Ploug, T., 2013, In: PloS one. 8, 10, p. e77774 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

1622 Downloads (Pure)

Ceramide content is higher in type I compared to type II fibers in obesity and type 2 diabetes mellitus

Kristensen, D. B., Prats Gavalda, C., Larsen, S., Ara, I., Dela, F., Helge, J. W. & Larsen, S., Oct 2013, In: Acta Diabetologica.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Contraction-induced lipolysis is not impaired by inhibition of hormone-sensitive lipase in skeletal muscle

Alsted, T. J., Ploug, T., Prats Gavalda, C., Serup, A. K., Høeg, L. D., Schjerling, P., Holm, C., Zimmermann, R., Fledelius, C., Galbo, H. & Kiens, B., Oct 2013, In: Journal of Physiology. 591, 20, p. 5141-5155 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice: impact of PGC-1α

Ringholm, S., Olesen, J., Pedersen, J. T., Brandt, C. T., Halling, J. F., Hellsten, Y., Prats Gavalda, C. & Pilegaard, H., Nov 2013, In: Experimental Gerontology. 48, 11, p. 1311-1318 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

Human skeletal muscle perilipin 2 and 3 expression varies with insulin sensitivity

Vigelsø Hansen, A., Prats Gavalda, C., Ploug, T., Dela, F. & Helge, J. W., May 2013, In: Journal of Biomedical Science and Engineering. 6, 5A, p. 65-72 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Impaired mitochondrial function in chronically ischemic human heart

Stride, N., Larsen, S., Hey-Mogensen, M., Hansen, C. N., Prats Gavalda, C., Steinbrüchel, D., Køber, L. & Dela, F., 1 Jun 2013, In: American Journal of Physiology: Heart and Circulatory Physiology. 304, 11, p. H1407-14 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

LKB1 regulates lipid oxidation during exercise independently of AMPK

Jeppesen, J. F., Maarbjerg, S. J., Jordy, A. B., Fritzen, A. M., Pehmøller, C., Sylow, L., Serup, A. K. L., Jessen, N., Thorsen, K., Prats Gavalda, C., Qvortrup, K., Dyck, J. R. B., Hunter, R. W., Sakamoto, K., Thomson, D. M., Schjerling, P., Wojtaszewski, J., Richter, E. & Kiens, B., May 2013, In: Diabetes. 62, 5, p. 1490-1499 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

Sylow, L., Jensen, T. E., Kleinert, M., Mouatt, J. R., Maarbjerg, S. J., Jeppesen, J. F., Prats Gavalda, C., Chiu, T. T., Boguslavsky, S., Klip, A., Schjerling, P. & Richter, E., Apr 2013, In: Diabetes. 62, 4, p. 1139-1151 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

95 Citations (Scopus)

Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle

Sylow, L., Jensen, T. E., Kleinert, M., Højlund, K., Kiens, B., Wojtaszewski, J., Prats Gavalda, C., Schjerling, P. & Richter, E., Jun 2013, In: Diabetes. 62, 6, p. 1865-1875 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

114 Citations (Scopus)

Subcellular localization and mechanism of secretion of vascular endothelial growth factor in human skeletal muscle

Høier, B., Prats Gavalda, C., Qvortrup, K., Pilegaard, H., Bangsbo, J. & Hellsten, Y., Sept 2013, In: F A S E B Journal. 27, 9, p. 3496-3504 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

2011

Intracellular compartmentalization of skeletal muscle glycogen metabolism and insulin signalling

Prats Gavalda, C., Gomez-Cabello, A. & Vigelsø Hansen, A., Apr 2011, In: Experimental Physiology. 96, 4, p. 385-390 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

2010

Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation

Axelsen, L. N., Lademann, J. B., Petersen, J. S., Holstein-Rathlou, N.-H., Ploug, T., Prats, C., Pedersen, H. D. & Kjølbye, A. L., Jun 2010, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 298, 6, p. R1560-70

Research output: Contribution to journal › Journal article › Research › peer-review

53 Citations (Scopus)

FAT/CD36 is localized in sarcolemma and in vesicle-like structures in subsarcolemma regions but not in mitochondria

Jeppesen, J., Mogensen, M., Prats, C., Sahlin, K., Madsen, K. & Kiens, B., 1 Jun 2010, In: Journal of Lipid Research. 51, 6, p. 1504-1512 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Muscle ceramide content in man is higher in type I than type II fibers and not influenced by glycogen content

Nordby, P., Prats, C., Kristensen, D., Ekroos, K., Forsberg, G., Andersen, J. L., Ploug, T., Dela, F., Storlien, L. & Helge, J. W., Jul 2010, In: Journal of Applied Physiology. 109, 5, p. 935-943 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes

Rabøl, R., Boushel, R., Almdal, T., Hansen, C. N., Ploug, T., Haugaard, S. B., Prats, C., Madsbad, S., Dela, F., Rabøl, R., Boushel, R., Almdal, T., Hansen, C. N., Ploug, T., Haugaard, S. B., Prats, C., Madsbad, S. & Dela, F., Sept 2010, In: Diabetic Medicine. 12, 9, p. 806-14 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes

Rabøl, R., Boushel, R., Almdal, T., Hansen, C. N., Ploug, T., Haugaard, S. B., Prats Gavalda, C., Madsbad, S. & Dela, F., Sept 2010, In: Diabetes, Obesity and Metabolism Online. 12, 9, p. 806-14 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

2009

Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization

Prats, C., Helge, J. W., Nordby, P., Qvortrup, K., Ploug, T., Dela, F. & Wojtaszewski, J., 2009, In: Journal of Biological Chemistry. 284, 23, p. 15692-15700 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

64 Citations (Scopus)

2008

Denervation and high-fat diet reduce insulin signaling in T-tubules in skeletal muscle of living mice

Lauritzen, H. P. M. M., Ploug, T., Ai, H., Donsmark, M., Prats, C. & Galbo, H., 2008, In: Diabetes. 57, 1, p. 13-23 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

Denervation and high-fat diet reduce insulin signaling in T-tubules in skeletal muscle of living mice

Lauritzen, H. P. M., Ploug, T., Ai, H., Donsmark, M., Prats Gavalda, C. & Galbo, H., Jan 2008, In: Diabetes. 57, 1, p. 13-23 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

2007

Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle

Hütter, E., Skovbro, M., Lener, B., Prats, C., Rabøl, R., Dela, F. & Jansen-Dürr, P., 2007, In: Aging Cell. 6, 2, p. 245-56 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

97 Citations (Scopus)

2006

Blood vessels and desmin control the positioning of nuclei in skeletal muscle fibers

Ralston, E., Lu, Z., Biscocho, N., Soumaka, E., Mavroidis, M., Prats, C., Lømo, T., Capetanaki, Y. & Ploug, T., 2006, In: Journal of Cellular Physiology. 209, 3, p. 874-882 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine.

Prats, C., Donsmark, M., Qvortrup, K., Londos, C., Sztalryd, C., Holm, C., Galbo, H. & Ploug, T., 2006, In: Journal of Lipid Research. 47, 11, p. 2392-9 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

77 Citations (Scopus)

Imaging of insulin signaling in skeletal muscle of living mice shows major role of T-tubules.

Lauritzen, H. P. M. M., Ploug, T., Prats, C., Tavaré, J. M. & Galbo, H., 2006, In: Diabetes. 55, 5, p. 1300-6 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

2005

Disturbances of the sarcoplasmic reticulum and transverse tubular system in 24-h electrostimulated fast-twitch skeletal muscle

Frías, J. A., Cadefau, J. A., Prats, C., Morán, M., Megías, A. & Cussó, R., 2005, In: BBA General Subjects. 1668, 1, p. 64-74 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Metallothionein-mediated antioxidant defense system and its response to exercise training are impaired in human type 2 diabetes

Scheede-Bergdahl, C., Penkowa, M., Hidalgo, J., Olsen, D. B., Schjerling, P., Prats, C., Boushel, R. & Dela, F., 2005, In: Diabetes. 54, 11, p. 3089-94 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

Phosphorylation-dependent translocation of glycogen synthase to a novel structure during glycogen resynthesis.

Prats, C., Cadefau, J. A., Cussó, R., Qvortrup, K., Nielsen, J. N., Wojtaszewski, J., Hardie, D. G., Stewart, G., Hansen, B. F. & Ploug, T., 2005, In: Journal of Biological Chemistry. 280, 24, p. 23165-72 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

53 Citations (Scopus)

2003

Differences between glycogen biogenesis in fast- and slow-twitch rabbit muscle

Cussó, R., Lerner, L. R., Cadefau, J., Gil, M., Prats, C., Gasparotto, M. & Krisman, C. R., 2003, In: BBA General Subjects. 1620, 1-3, p. 65-71 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

2002

Glycogen depletion and resynthesis during 14 days of chronic low-frequency stimulation of rabbit muscle

Prats, C., Bernal, C., Cadefau, J. A., Frias, J., Tibolla, M. & Cussó, R., 2002, In: BBA General Subjects. 1573, 1, p. 68-74 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

2001

The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise

Aschenbach, W. G., Suzuki, Y., Breeden, K., Prats, C., Hirshman, M. F., Dufresne, S. D., Sakamoto, K., Vilardo, P. G., Steele, M., Kim, J. H., Jing, S. L., Goodyear, L. J. & DePaoli-Roach, A. A., 2001, In: Journal of Biological Chemistry. 276, 43, p. 39959-67 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

93 Citations (Scopus)

Clara Prats Gavalda

Research output

Search results