Differences between glycogen biogenesis in fast- and slow-twitch rabbit muscle

TY - JOUR

T1 - Differences between glycogen biogenesis in fast- and slow-twitch rabbit muscle

AU - Cussó, R

AU - Lerner, L R

AU - Cadefau, J

AU - Gil, M

AU - Prats, C

AU - Gasparotto, M

AU - Krisman, C R

N1 - Keywords: Animals; Glucose-6-Phosphate; Glycogen; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Rabbits

PY - 2003

Y1 - 2003

N2 - Skeletal muscle glycogen is an essential energy substrate for muscular activity. The biochemical properties of the enzymes involved in de novo synthesis of glycogen were analysed in two types of rabbit skeletal muscle fiber (fast- and slow-twitch). Glycogen concentration was higher in fast-twitch muscle than in slow-twitch muscle, but the latter contained many more small intermediate-acceptor molecules that could act as glycogen synthase substrates. The enzymes involved in de novo synthesis of glycogen in fast-twitch muscle were strongly stimulated by Glc-6-P, but those in slow-twitch muscle were not.

AB - Skeletal muscle glycogen is an essential energy substrate for muscular activity. The biochemical properties of the enzymes involved in de novo synthesis of glycogen were analysed in two types of rabbit skeletal muscle fiber (fast- and slow-twitch). Glycogen concentration was higher in fast-twitch muscle than in slow-twitch muscle, but the latter contained many more small intermediate-acceptor molecules that could act as glycogen synthase substrates. The enzymes involved in de novo synthesis of glycogen in fast-twitch muscle were strongly stimulated by Glc-6-P, but those in slow-twitch muscle were not.

M3 - Journal article

C2 - 12595075

SN - 0304-4165

VL - 1620

SP - 65

EP - 71

JO - B B A - General Subjects

JF - B B A - General Subjects

IS - 1-3

ER -