Poul Hyttel

Short presentation

Brief CURRICULUM VITAE for Poul Hyttel (born September 19, 1954)

1. Academic degrees

2011:                  Dhc (doctor honoris causa)

1988:                  DVSc (doctor medicinae veterinariae)

1982:                  PhD (licentia medicinae veterinariae)

1979:                  DVM (Doctor of Veterinary Medicine, candidatus medicinae veterinarius)

2. Appointments

1990-now:         Professor of Anatomy, Department of Anatomy and Physiology, Royal Veterinary and Agricultural University (KVL); now Department of Veterinary Clinical and Animal Sciences (DVCAS), Faculty of Health and Medical Sciences, University of Copenhagen

1999-2000:       Six months Guest Professorship, Monash University, Melbourne, Australia

1988-1990:       Associate Professor, Department for Animal Reproduction, KVL

1982-1988:       Assistant and Associate Professor, Department of Anatomy, KVL

1979-1982:       PhD-student, Department for Animal Reproduction, KVL

3. Research activities

Pluripotent porcine and human stem cells

A Class I stem cell laboratory has been established at DVCAS approved for work on genetically modified cells. The major contemporary projects focus on (1) establishment of human patient-specific neural in vitro cell models for neurodegenerative disorders by the use of induced pluripotent stem cells (iPSC) (supported by Danish National Advanced Technology Foundation, EU and Innovation Fund Denmark) and (2) basic studies of porcine iPSC for the development of the pig as a translational model for iPSC-based cell therapy (supported by Danish Agency for Science, Technology and Innovation).

In vitro production (IVP) of bovine embryos

Bovine IVP is optimized by improved oocyte maturation and embryo culture technologies. Quantitative genomics is applied for precise selection of donors for ovum pick up, high quality embryos, and fertile recipients (supported by The Danish Council for Strategic Research).

4. Supervision of PhD students

Principal supervisor of 25 PhD students (7 on-going programs).

5. Attraction of grants (over the past 6 years)

Since 1985 accumulation of approximately 130 million DKK (17,4 million €).

2013

• Programme Commission on Health, Food and Welfare of the Danish Council for Strategic Research, Genomic Improvement of Fertilization Traits in Danish and Brazilian Cattle (GIFT), 6,059,520 DKK; 2013-2017 (PI: Haja Kadarmideen).

2012

• EU COST Action Epigenetics and periconception environment - Periconception environment as an epigenomic lever for optimising food production and health in livestock.
• Coordinator of EU IAPP Marie Curie action ”Patient-specific stem cell-derived models for Alzheimer’s disease and related neurodegenerative disorders (STEMMAD), 2,800,000 €.

2011

• Højteknologifonden (Danish National Advanced Technology Foundation), Patient-specific stem cell-derived models for Alzheimer’s disease, 13,972,500 DKK; 2011-2014.
• FNU (Danish Agency for Science, Technology and Innovation), Cell reprogramming – basic developmental studies in the pig, 5,575,732 DKK; 2012-2015.
• USDA, Developmental programming during preimplantation development, 259,645 USD; 2011-2015.
• SHARE PhD stipend, 1,200,000 DKK; 2012-2015.
• DSF (Danish Agency for Science, Technology and Innovation), COGNITO – Novel treatments of cognitive dysfunction, 2,088,000 DKK, 2011-2016.

2008

• EU FP7 Comparative embryonic stem cell research in mammalians “PartnErS” (Grant Agreement Number 218205), 204,523 €, 2008-2012).
• EU FP7 Systems biology approaches to understand cell pluripotency “Plurisys” (Grant Agreement Number 223485), 364,000 €, 2008-2012).
• Højteknologifonden (Danish National Advanced Technology Foundation), 4D CellVision, 1,200,500 DKK, 2009-2013.

2014

• Danish Innovation Foundation. BrainStem – Stem cell center of excellence. 24,000,000 DKK, 2015-2020.
• Danish Innovation Foundation. NeuroStem - Stem cell models for discovery of RNA-mediated regulation in neurodegeneration. 5,000,000 DKK (2015-2019)

2015

• Danish Agency for Science, Technology and Innovation. Establishment of demented dogs as a superior model for Alzheimer's disease. 6,479,280 DKK (2015-2018)

6. Managerial skills and leadership experience

Coordinator of the EU-funded Marie Curie project STEMMAD including activities at universities and SMEs in Hungary, Thailand, and Denmark. Coordinator of several large research projects supported by the Research Councils and the Danish Advanced Technology Foundation. More than 20 years’ experience as Professor and Group Leader of an organization, which presently includes 3 associate professors, a project manager, 3 postdocs, 4 laboratory technicians, 8 PhD students, and a varying number of guest researchers, bachelor, and master students. Director of BrainStem. 

7. Awards and distinguished services

1985:                  Dr. med. h.c. C.O. Jensen’s Memorial Foundation.

1990:                  Brinch's Memorial Foundation.

1991:                  "The golden bull" as teacher of the year at KVL.

1997-1998:          President of the International Embryo Transfer Society (IETS).

1998:                  Carlsberg’s Research Award for promotion of agricultural research (100,000 DKK).

2010:                  DLT Smith Short Visitorship, University of Saskatchewan, Saskatoon, Canada.

2011:                  Doctor honoris causa, University of Antwerpen, Belgium.

2014:                  Ridder af 1. grad af Dannebrogsordenen.

2015:                  “Saly’s horse” as teacher of the year at University of Copenhagen.

8. Bibliometrics and selected publications

More than 220 publications in international refereed journals, H-index: 51, 8575 citations per July 21, 2015(Google Scholar).

Freude, K., Pires, C., Hyttel, P. and Hall, V. (2014): Induced Pluripotent Stem Cells Derived from Alzheimer’s Disease Patients: The Promise, the Hope and the Path Ahead. J. Clin. Med. 3:1402-1436; doi:10.3390/jcm3041402.

Høffding, M.K. and Hyttel, P. (2014): Ultrastructural visualization of the mesenchymal-to-epithelial transition during reprogramming of human fibroblasts to induced pluripotent stem cells. Stem Cell Res 14:39–53.

Hall, V.J. and Hyttel, P. (2014): Breaking Down Pluripotency in the Porcine Embryo Reveals Both a Premature and Reticent Stem Cell State in the Inner Cell Mass and Unique Expression Profiles of the Naive and Primed Stem Cell States. Stem Cells and Dev. 23:2030-2045.

Rasmussen, M.A., Holst, B., Tümer, Z., Johnsen, M.G., Zhou, S., Stummann, T.C., Hyttel, P. and Clausen, C. (2014): Transient p53 suppression increases reprogramming of human fibroblasts without affecting apoptosis and DNA damage.  Stem Cell Reports, 12:609-616.

Hall, V., Hinrichs, K., Lazzari, G., Betts, D.H. and Hyttel, P. (2013): Early embryonic development, assisted reproductive technologies, and pluripotent stem cell biology in domestic mammals. Vet. J. 197:128–142.

Hall, V., Kristensen, M., Rasmussen, M., Ujhelly, O., Dinnyés, A. and Hyttel, P. (2012): Temporal repression of endogenous pluripotency genes during reprogramming of porcine induced pluripotent stem cells. Cellular Reprogramming, 3:1-13.

Deshmukh, R., Oestrup, O., Strejcek, F., Vejlsted, M., Lucas-Hahn, A., Petersen, B., Li, J., Callesen, H., Niemann, H. and Hyttel, P. (2012): Early aberrations in chromatin dynamics in embryos produced under in vitro conditions. Cellular Reprogramming 14:225-234.

Gao, Y., Jammes, H., Rasmussen, M.A., Oestrup, O., Beaujean, N., Hall, V. and Hyttel, P. (2011): Epigenetic regulation of gene expression in porcine epiblast, hypoblast, trophectoderm and epiblast-derived neural progenitor cells. Epigenetics 6:9, 1149-1161.

Gao, Y., Hyttel, P., Hall, V.J. (2011): Dynamic changes in epigenetic marks and gene expression during porcine epiblast specification. Cell Reprogram. 13:345-60.

Rasmussen, M., Hall, V.J., Carter, T. and Hyttel, P. (2011): Directed differentiation of porcine epiblast-derived neural progenitor cells into neurons and glia. Stem Cell Research 7:124–136.

Wolf, X.A., Serup, P. and Hyttel, P. (2011): Three-Dimensional immunohistochemical characterization of lineage commitment by localization of T and FOXA2 in porcine peri-implantation embryos. Dev. Dyn. 240:890-7.

Petkov, S.G., Marks, H., Klein, T., Garcia, R.S., Gao, Y., Stunnenberg, H. and Hyttel, P. (2011): In vitro culture and characterization of putative porcine embryonic germ cells derived from the domestic breeds and Yucatan mini pig embryos at days 20-24 of gestation. Stem Cell Res. 6:226-237.

Deshmukh, R.S, Østrup, O., Østrup, E., Vejlsted, M., Niemann, H., Lucas-Hahn, A., Petersen, B., Li, J., Callesen, H. and Hyttel, P. (2011): DNA methylation in porcine preimplantation embryos developed in-vivo and produced by in-vitro fertilization, parthenogenetic activation and somatic cell nuclear transfer. Epigenetics 6:1-11.

Wolf, X., Serup, P., Hyttel, P. (2011): Three-dimensional localisation of NANOG, OCT4 and E-CADHERIN in porcine pre- and peri-implantation embryos. Dev. Dyn. 240:204-210.

Deshmukh, R.S, Østrup, O., Østrup, E., Vejlsted, M., Niemann, H., Lucas-Hahn, A., Petersen, B., Li, J., Callesen, H. and Hyttel, P. (2011): DNA methylation in porcine preimplantation embryos developed in-vivo and produced by in-vitro fertilization, parthenogenetic activation and somatic cell nuclear transfer. Epigenetics 6:1-11.