Primary fields of research

The research activities of my group are directed towards interrogating the signaling pathways controlling cellular and whole body glucose and lipid homeostasis in cell-based and animal models. To resolve the physiological role of genes, proteins, and pathways that regulate insulin action and adiposity, we use transgenic animals harboring mutant and wild-type forms of candidate genes or knockout deletions. We are developing in vitro and in vivo methods to assess the functional role of novel targets in type 2 diabetes and obesity pathogenesis as well as performing clinical and experimental studies for genotype/phenotype interactions to identify diabetes risk and mechanisms underlying diabetes pathogenesis.