Lotte Bang Pedersen

2019

A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling

Frikstad, K-A. M., Molinari, E., Thoresen, M., Ramsbottom, S. A., Hughes, F., Letteboer, S. J. F., Gilani, S., Schink, K. O., Stokke, T., Geimer, S., Pedersen, L. B., Giles, R. H., Akhmanova, A., Roepman, R., Sayer, J. A. & Patzke, S., 13 Aug 2019, In: Cell Reports. 28, 7, p. 1907-1922, e1-e6

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

30 Downloads (Pure)

Cellular signalling by primary cilia in development, organ function and disease

Anvarian, Z., Mykytyn, K., Mukhopadhyay, S., Pedersen, L. B. & Christensen, S. T., 1 Apr 2019, In: Nature Reviews Nephrology. 15, p. 199-219

Research output: Contribution to journal › Review › peer-review

105 Citations (Scopus)

2018

CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium

Mönnich, M., Borgeskov, L., Breslin, L., Jakobsen, L., Rogowski, M., Doganli, C., Schrøder, J. M., Mogensen, J. B., Blinkenkjær, L., Harder, L. M., Lundberg, E., Geimer, S., Christensen, S. T., Andersen, J. S., Larsen, L. A. & Pedersen, L. B., 6 Mar 2018, In: Cell Reports. 22, 10, p. 2584-2592 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

111 Downloads (Pure)

Challenges for the sustainability of university-run biobanks

Kongsholm, N. C. H., Christensen, S. T., Herrmann, J. R., Larsen, L. A., Minssen, T., Pedersen, L. B., Rajam, N., Tommerup, N., Tupasela, A. M. & Schovsbo, J. H., Aug 2018, In: Biopreservation and Biobanking. 16, 4, p. 312-321 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

62 Downloads (Pure)

IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases

Schmid, F. M., Schou, K. B., Vilhelm, M. J., Holm, M. S., Breslin, L., Farinelli, P., Larsen, L. A., Andersen, J. S., Pedersen, L. B. & Christensen, S. T., 1 Jan 2018, In: Journal of Cell Biology. 217, 1, p. 151-161 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

67 Downloads (Pure)

Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins

Morthorst, S. K., Christensen, S. T. & Pedersen, L. B., Dec 2018, In: F E B S Journal. 285, 24, p. 4535-4564

Research output: Contribution to journal › Review › peer-review

9 Citations (Scopus)

The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development

Rasmussen, K. K., Skat-Rørdam, J., Andersen, P., Warzecha, C. B., Pye, M., Andersen, T. A., Ajbro, K. D., Bendsen, E., Narimatsu, M., Vilhardt, F., Pedersen, L. B., Wrana, J. L., Anderson, R. H., Møllgård, K., Christensen, S. T. & Larsen, L. A., 2018, In: Scientific Reports. 8, 1, 14 p., 9542.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

82 Downloads (Pure)

TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms

Rosengren, T., Larsen, L. J., Pedersen, L. B., Christensen, S. T. & Møller, L. B., 1 Jul 2018, In: Cellular and Molecular Life Sciences. 75, 14, p. 2663-2680 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

48 Downloads (Pure)

2017

KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.

Schou, K. B., Mogensen, J. B., Morthorst, S. K., Nielsen, B. S., Aleliunaite, A., Serra-Marques, A., Fürstenberg, N., Saunier, S., Bizet, A. A., Veland, I. R., Akhmanova, A., Christensen, S. T. & Pedersen, L. B., 30 Jan 2017, In: Nature Communications. 8, 15 p., 14177.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

526 Downloads (Pure)

Primary cilia and coordination of receptor tyrosine kinase (RTK) and transforming growth factor β (TGF-β) signaling

Christensen, S. T., Morthorst, S. K., Mogensen, J. B. & Pedersen, L. B., Jun 2017, In: Cold Spring Harbor Perspectives in Biology. 9, 6, 18 p., a028167.

Research output: Contribution to journal › Journal article › Research › peer-review

44 Citations (Scopus)

Tubulin transport in cilia: how many tubulin cargo-binding sites per IFT particle? (retrospective on DOI 10.1002/bies.201400007)

Pedersen, L. B., 1 Jan 2017, In: BioEssays. 39, 1, 1 p.

Research output: Contribution to journal › Comment/debate › Research › peer-review

2016

Cilia and flagella

Schmid, F. M., Christensen, S. T. & Pedersen, L. B., 2016, Encyclopedia of cell biology. Bradshaw, R. A. & Stahl, P. D. (eds.). 1 ed. Elsevier, Vol. 2. p. 660-676 17 p.

Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Research › peer-review

1 Citation (Scopus)

Endocytic control of cellular signaling at the primary cilium

Pedersen, L. B., Mogensen, J. B. & Christensen, S. T., 1 Sept 2016, In: Trends in Biochemical Sciences. 41, 9, p. 784-797 14 p.

Research output: Contribution to journal › Review › peer-review

57 Citations (Scopus)

Targeting of ASH domain-containing proteins to the centrosome

Verdier, P., Morthorst, S. K. & Pedersen, L. B., 2016, Cilia. Satir, P. & Tvorup Christensen, S. (eds.). Springer, p. 15-33 19 p. (Methods in Molecular Biology, Vol. 1454).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

1 Citation (Scopus)

2015

Ins and outs of GPCR signaling in primary cilia

Schou, K. B., Pedersen, L. B. & Christensen, S. T., 1 Sept 2015, In: E M B O Reports. 16, 9, p. 1099-1113 15 p.

Research output: Contribution to journal › Review › peer-review

92 Citations (Scopus)

PDGFRβ and oncogenic mutant PDGFRα D842V promote disassembly of primary cilia through a PLCγ- and AURKA-dependent mechanism

Nielsen, B. S., Malinda, R. R., Schmid, F. M., Pedersen, S. H. F., Christensen, S. T. & Pedersen, L. B., 2015, In: Journal of Cell Science. 128, p. 3543-3549 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathies

Benmerah, A., Durand, B., Giles, R. H., Harris, T., Kohl, L., Laclef, C., Meilhac, S. M., Mitchison, H. M., Pedersen, L. B., Roepman, R., Swoboda, P., Ueffing, M. & Bastin, P., 31 Mar 2015, In: Cilia. 4, 5, 14 p.

Research output: Contribution to journal › Conference article › Research

5 Citations (Scopus)

75 Downloads (Pure)

2014

A divergent calponin homology (NN–CH) domain defines a novel family: implications for evolution of ciliary IFT complex B proteins

Schou, K. B., Andersen, J. S. & Pedersen, L. B., 1 Apr 2014, In: Bioinformatics. 30, 7, p. 899-902 4 p.

Research output: Contribution to journal › Letter › peer-review

25 Citations (Scopus)

ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis

Goggolidou, P., L. Stevens, J., Agueci, F., Keynton, J., Wheway, G., T. Grimes, D., H. Patel, S., Hilton, H., Morthorst, S. K., DiPaolo, A., J. Williams, D., Sanderson, J., V. Khoronenkova, S., Powles-Glover, N., Ermakov, A., T. Esapa, C., Romero, R., L. Dianov, G., Briscoe, J., A. Johnson, C., & 2 othersPedersen, L. B. & P. Norris, D., 1 Oct 2014, In: Development. 141, p. 3966-3977 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

575 Downloads (Pure)

Cilia and coordination of signaling networks during heart development

Koefoed, K., Veland, I. R., Pedersen, L. B., Larsen, L. A. & Christensen, S. T., 2014, In: Organogenesis. 10, 1, p. 108-125 18 p.

Research output: Contribution to journal › Review › peer-review

49 Citations (Scopus)

Editorial

Pedersen, L. B., 2014, In: Cilia. 3, 8, 2 p.

Research output: Contribution to journal › Editorial

227 Downloads (Pure)

Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8

Schou, K. B., Morthorst, S. K., Christensen, S. T. & Pedersen, L. B., 2014, In: Cilia. 3, 6, 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1592 Downloads (Pure)

Kif7 keeps cilia tips in shape

Pedersen, L. B. & Akhmanova, A., Jul 2014, In: Nature Cell Biology. 16, 7, p. 623-625 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis

Kypri, E., Christodoulou, A., Maimaris, G., Lethan, M., Markaki, M., Lysandrou, C., Lederer, C., Tavernarakis, N., Geimer, S., Pedersen, L. B. & Santama, N., Feb 2014, In: Cellular and molecular life sciences : CMLS. 71, 3, p. 517-538 22 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

2013

Analysis of microtubule plus-end-tracking proteins in cilia

Larsen, J., Grigoriev, I., Akhmanova, A. & Pedersen, L. B., 2013, Cilia, Part A. Marshall, W. F. (ed.). Elsevier, p. 105-122 18 p. (Methods in Enzymology, Vol. 524).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

3 Citations (Scopus)

Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration

Veland, I. R., Montjean, R., Eley, L., Pedersen, L. B., Schwab, A., Goodship, J., Kristiansen, K., Pedersen, S. H. F., Saunier, S. & Christensen, S. T., 8 Apr 2013, In: P L o S One. 8, 4, 15 p., e60193.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

2166 Downloads (Pure)

TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

Clement, C. A., Ajbro, K. D., Koefoed, K., Vestergaard, M. L., Veland, I. R., Perestrello Ramos H de Jesus, M., Pedersen, L. B., Benmerah, A., Andersen, C. Y., Larsen, L. A. & Christensen, S. T., 27 Mar 2013, In: Cell Reports. 3, 6, p. 1806-1814 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

169 Citations (Scopus)

116 Downloads (Pure)

2012

A proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins

Jiang, K., Toedt, G., Gouveia, S. M., Davey, N. E., Hua, S., Vaart, B. V. D., Grigoriev, I., Larsen, J., Pedersen, L. B., Bezstarosti, K., Lince-Faria, M., Demmers, J., Steinmetz, M. O., Gibson, T. J. & Akhmanova, A., 9 Oct 2012, In: Current biology : CB. 22, 19, p. 1800-1807 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

127 Citations (Scopus)

Primary cilia and aberrant cell signaling in epithelial ovarian cancer

Egeberg, D. L., Lethan, M., Manguso, R., Schneider, L., Awan, A., Jørgensen, T. S., Byskov, A. G., Pedersen, L. B. & Christensen, S. T., 10 Aug 2012, In: Cilia. 1, 15, 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

48 Citations (Scopus)

1152 Downloads (Pure)

Primary cilia and coordination of receptor tyrosine kinase (RTK) signaling

Christensen, S. T., Clement, C. A., Satir, P. & Pedersen, L. B., Jan 2012, In: Journal of Pathology. 226, 2, p. 172-184 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

110 Citations (Scopus)

Regulating intraflagellar transport

Pedersen, L. B. & Christensen, S. T., Sept 2012, In: Nature Cell Biology. 14, 9, p. 904-906 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

The ciliary cytoskeleton

Pedersen, L. B., Schrøder, J. M., Satir, P. & Christensen, S. T., Jan 2012, In: Comprehensive Physiology. 2, 1, p. 779-803 25 p.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

2011

EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms

Schrøder, J. M., Larsen, J., Komarova, Y., Akhmanova, A., Thorsteinsson, R. I., Grigoriev, I., Manguso, R., Christensen, S. T., Pedersen, S. H. F., Geimer, S. & Pedersen, L. B., 1 Aug 2011, In: Journal of Cell Science. 124, p. 2539-51 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

74 Citations (Scopus)

2010

The primary cilium at a glance

Satir, P., Pedersen, L. B. & Christensen, S. T., 15 Feb 2010, In: Journal of Cell Science. 123, Pt 4, p. 499-503 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

312 Citations (Scopus)

2009

Primary cilia and signaling pathways in mammalian development, health and disease

Veland, I. R., Awan, A., Pedersen, L. B., Yoder, B. K. & Christensen, S. T., 2009, In: NEPHRON PHYSIOLOGY. 111, 3, p. p39-53

Research output: Contribution to journal › Journal article › Research › peer-review

195 Citations (Scopus)

The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium

Schneider, L., Stock, C-M., Dieterich, P., Jensen, B. H., Pedersen, L. B., Satir, P., Schwab, A., Christensen, S. T. & Pedersen, S. F., 2009, In: Journal of Cell Biology. 185, 1, p. 163-76 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

72 Citations (Scopus)

Using quantitative PCR to Identify Kinesin-3 Genes that are Upregulated During Growth Arrest in MouseNIH3T3 Cells

Thorsteinsson, R., Christensen, S. T. & Pedersen, L. B., 2009, Methods in Cell Biology. Sloboda, R. D. (ed.). Academic Press, Vol. 94. p. 66-86

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

Using quantitative PCR to identify kinesin-3 genes that are upregulated during growth arrest in mouse NIH3T3 cells.

Thorsteinsson, R. I., Christensen, S. T. & Pedersen, L. B., 1 Jan 2009, In: Methods in Cell Biology. 94, p. 66-86 21 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

2008

Assembly of primary cilia.

Pedersen, L. B., Veland, I. R., Schrøder, J. M. & Christensen, S. T., 2008, In: Developmental Dynamics. 237, p. 1993-2006 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

153 Citations (Scopus)

Intraflagellar Transport (IFT) Role in Ciliary Assembly, Resorption and Signalling

Pedersen, L. B. & Rosenbaum, J. L., 2008, In: Current Topics in Developmental Biology. 85, p. 23-61 38 p.

Research output: Contribution to journal › Journal article › Research › peer-review

366 Citations (Scopus)

2007

Chlamydomonas FAP133 is a dynein intermediate chain associated with the retrograde intraflagellar transport motor

Rompolas, P., Pedersen, L. B., Patel-King, R. & King, S., 2007, In: Journal of Cell Science. 120, p. 3653-3665 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

78 Citations (Scopus)

EB1 is required for primary cilia assembly in fibroblasts.

Schrøder, J. M., Schneider, L., Christensen, S. T. & Pedersen, L. B., 2007, In: Current Biology. 17, 13, p. 1134-9 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

50 Citations (Scopus)

Kroppens indre antenner

Pedersen, L. B. & Christensen, S. T., 2007, In: Aktuel Naturvidenskab. 2, p. 10-13

Research output: Contribution to journal › Journal article › Communication

Sensory cilia and integration of signal transduction in human health and disease.

Christensen, S. T., Pedersen, L. B., Schneider, L. & Satir, P., 2007, In: Traffic - International Journal of Intracellular Transport. 8, 2, p. 97-109 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

189 Citations (Scopus)

The lissencephaly protein Lis1 is present in motile mammalian cilia and requires outer arm dynein for targeting to Chlamydomonas flagella.

Pedersen, L. B., Rompolas, P., Christensen, S. T., Rosenbaum, J. L. & King, S. M., 2007, In: Journal of Cell Science. 120, Pt 5, p. 858-67 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

2006

Dissecting the molecular mechanisms of intraflagellar transport in Chlamydomonas.

Pedersen, L. B., Geimer, S. & Rosenbaum, J. L., 2006, In: Current Biology. 16, 5, p. 450-459

Research output: Contribution to journal › Journal article › Research › peer-review

115 Citations (Scopus)

2005

ATP Production in Chlamydomonas reinhardtii Flagella by Glycolytic Enzymes

Mitchell, B. F., Pedersen, L. B., Feely, M., Rosenbaum, J. L. & Mitchell, D. R., 2005, In: Molecular Biology of the Cell. 16, 10, p. 4509-18 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

78 Citations (Scopus)

Chlamydomonas IFT172 is encoded by FLA11, interacts with CrEB1, and regulates IFT at the flagellar tip.

Pedersen, L. B., Miller, M. S., Geimer, S., Leitch, J. M., Rosenbaum, J. L. & Cole, D. G., 2005, In: Current Biology. 15, 3, p. 262-6 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

109 Citations (Scopus)

2003

The Microtubule plus end-tracking protein EB1 is localized to the flagellar tip and basal bodies in Chlamydomonas reinhardtii.

Pedersen, L. B., Geimer, S., Sloboda, R. D. & Rosenbaum, J. L., 2003, In: Current Biology. 13, 22, p. 1969-74 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

90 Citations (Scopus)

2000

Analysis of the Function of a Putative 2,3-Diphosphoglyceric Acid-Dependent Phosphoglycerate Mutase from Bacillus subtilis

Pearson, C. L., Loshon, C. A., Setlow, P., Pedersen, L. B. & Setlow, B., 2000, In: Journal of Bacteriology. 182, 14, p. 4121-3 2 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Lotte Bang Pedersen

Research output

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