TY - JOUR
T1 - Primary cilia and coordination of receptor tyrosine kinase (RTK) and transforming growth factor β (TGF-β) signaling
AU - Christensen, Søren Tvorup
AU - Morthorst, Stine Kjær
AU - Mogensen, Johanne Bay
AU - Pedersen, Lotte Bang
N1 - Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2017/6
Y1 - 2017/6
N2 - Since the beginning of the millennium, research in primary cilia has revolutionized our way of understanding how cells integrate and organize diverse signaling pathways during vertebrate development and in tissue homeostasis. Primary cilia are unique sensory organelles that detect changes in their extracellular environment and integrate and transmit signaling information to the cell to regulate various cellular, developmental, and physiological processes. Many different signaling pathways have now been shown to rely on primary cilia to function properly, and mutations that lead to ciliary dysfunction are at the root of a pleiotropic group of diseases and syndromic disorders called ciliopathies. In this review, we present an overview of primary cilia-mediated regulation of receptor tyrosine kinase (RTK) and transforming growth factor b (TGF-b) signaling. Further, we discuss how defects in the coordination of these pathways may be linked to ciliopathies.
AB - Since the beginning of the millennium, research in primary cilia has revolutionized our way of understanding how cells integrate and organize diverse signaling pathways during vertebrate development and in tissue homeostasis. Primary cilia are unique sensory organelles that detect changes in their extracellular environment and integrate and transmit signaling information to the cell to regulate various cellular, developmental, and physiological processes. Many different signaling pathways have now been shown to rely on primary cilia to function properly, and mutations that lead to ciliary dysfunction are at the root of a pleiotropic group of diseases and syndromic disorders called ciliopathies. In this review, we present an overview of primary cilia-mediated regulation of receptor tyrosine kinase (RTK) and transforming growth factor b (TGF-b) signaling. Further, we discuss how defects in the coordination of these pathways may be linked to ciliopathies.
U2 - 10.1101/cshperspect.a028167
DO - 10.1101/cshperspect.a028167
M3 - Journal article
C2 - 27638178
SN - 1943-0264
VL - 9
JO - Cold Spring Harbor Perspectives in Biology
JF - Cold Spring Harbor Perspectives in Biology
IS - 6
M1 - a028167
ER -