Endocytic control of cellular signaling at the primary cilium

Lotte Bang Pedersen; Johanne Bay Mogensen; Søren Tvorup Christensen

doi:10.1016/j.tibs.2016.06.002

Endocytic control of cellular signaling at the primary cilium

Lotte Bang Pedersen, Johanne Bay Mogensen, Søren Tvorup Christensen

Cell Biology and Physiology

57 Citations (Scopus)

Abstract

Primary cilia are dynamic signaling organelles that project from the cell surface to sense diverse chemical, physical and morphogenetic cues. Ciliary defects therefore cause diseases (ciliopathies) that affect multiple organs in developing and adult organisms. Cilia-mediated signaling involves the orchestrated movement of signaling proteins in and out of the ciliary compartment, including movement of receptors such as the Sonic Hedgehog (Shh) receptor Patched 1 (PTCH1), Smoothened (SMO), and various other G protein-coupled receptors (GPCRs), as well as transforming growth factor β (TGF-β) receptors I and II (TGF-β-RI/II). We provide here a current understanding of trafficking events associated with cilia-mediated signaling, with emphasis on the involvement of clathrin-dependent receptor-mediated endocytosis in regulating ciliary Shh and TGF-β signaling.

Original language	English
Journal	Trends in Biochemical Sciences
Volume	41
Issue number	9
Pages (from-to)	784-797
Number of pages	14
ISSN	0968-0004
DOIs	https://doi.org/10.1016/j.tibs.2016.06.002
Publication status	Published - 1 Sept 2016

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title = "Endocytic control of cellular signaling at the primary cilium",

abstract = "Primary cilia are dynamic signaling organelles that project from the cell surface to sense diverse chemical, physical and morphogenetic cues. Ciliary defects therefore cause diseases (ciliopathies) that affect multiple organs in developing and adult organisms. Cilia-mediated signaling involves the orchestrated movement of signaling proteins in and out of the ciliary compartment, including movement of receptors such as the Sonic Hedgehog (Shh) receptor Patched 1 (PTCH1), Smoothened (SMO), and various other G protein-coupled receptors (GPCRs), as well as transforming growth factor β (TGF-β) receptors I and II (TGF-β-RI/II). We provide here a current understanding of trafficking events associated with cilia-mediated signaling, with emphasis on the involvement of clathrin-dependent receptor-mediated endocytosis in regulating ciliary Shh and TGF-β signaling.",

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T1 - Endocytic control of cellular signaling at the primary cilium

AU - Pedersen, Lotte Bang

AU - Mogensen, Johanne Bay

AU - Christensen, Søren Tvorup

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Primary cilia are dynamic signaling organelles that project from the cell surface to sense diverse chemical, physical and morphogenetic cues. Ciliary defects therefore cause diseases (ciliopathies) that affect multiple organs in developing and adult organisms. Cilia-mediated signaling involves the orchestrated movement of signaling proteins in and out of the ciliary compartment, including movement of receptors such as the Sonic Hedgehog (Shh) receptor Patched 1 (PTCH1), Smoothened (SMO), and various other G protein-coupled receptors (GPCRs), as well as transforming growth factor β (TGF-β) receptors I and II (TGF-β-RI/II). We provide here a current understanding of trafficking events associated with cilia-mediated signaling, with emphasis on the involvement of clathrin-dependent receptor-mediated endocytosis in regulating ciliary Shh and TGF-β signaling.

AB - Primary cilia are dynamic signaling organelles that project from the cell surface to sense diverse chemical, physical and morphogenetic cues. Ciliary defects therefore cause diseases (ciliopathies) that affect multiple organs in developing and adult organisms. Cilia-mediated signaling involves the orchestrated movement of signaling proteins in and out of the ciliary compartment, including movement of receptors such as the Sonic Hedgehog (Shh) receptor Patched 1 (PTCH1), Smoothened (SMO), and various other G protein-coupled receptors (GPCRs), as well as transforming growth factor β (TGF-β) receptors I and II (TGF-β-RI/II). We provide here a current understanding of trafficking events associated with cilia-mediated signaling, with emphasis on the involvement of clathrin-dependent receptor-mediated endocytosis in regulating ciliary Shh and TGF-β signaling.

U2 - 10.1016/j.tibs.2016.06.002

DO - 10.1016/j.tibs.2016.06.002

M3 - Review

C2 - 27364476

SN - 0968-0004

VL - 41

SP - 784

EP - 797

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 9

ER -

Endocytic control of cellular signaling at the primary cilium

Abstract

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