TY - JOUR
T1 - Primary cilia and coordination of receptor tyrosine kinase (RTK) signaling
AU - Christensen, Søren Tvorup
AU - Clement, Christian Alexandro
AU - Satir, Peter
AU - Pedersen, Lotte Bang
N1 - Special Issue: The Cell Biology of Disease
PY - 2012/1
Y1 - 2012/1
N2 - Primary cilia are microtubule-based sensory organelles that coordinate signalling pathways in cell-cycle control, migration, differentiation and other cellular processes critical during development and for tissue homeostasis. Accordingly, defects in assembly or function of primary cilia lead to a plethora of developmental disorders and pathological conditions now known as ciliopathies. In this review, we summarize the current status of the role of primary cilia in coordinating receptor tyrosine kinase (RTK) signalling pathways. Further, we present potential mechanisms of signalling crosstalk and networking in the primary cilium and discuss how defects in ciliary RTK signalling are linked to human diseases and disorders.
AB - Primary cilia are microtubule-based sensory organelles that coordinate signalling pathways in cell-cycle control, migration, differentiation and other cellular processes critical during development and for tissue homeostasis. Accordingly, defects in assembly or function of primary cilia lead to a plethora of developmental disorders and pathological conditions now known as ciliopathies. In this review, we summarize the current status of the role of primary cilia in coordinating receptor tyrosine kinase (RTK) signalling pathways. Further, we present potential mechanisms of signalling crosstalk and networking in the primary cilium and discuss how defects in ciliary RTK signalling are linked to human diseases and disorders.
U2 - 10.1002/path.3004
DO - 10.1002/path.3004
M3 - Journal article
C2 - 21956154
SN - 0022-3417
VL - 226
SP - 172
EP - 184
JO - Journal of Pathology
JF - Journal of Pathology
IS - 2
ER -
