Cilia and coordination of signaling networks during heart development

TY - JOUR

T1 - Cilia and coordination of signaling networks during heart development

AU - Koefoed, Karen

AU - Veland, Iben Rønn

AU - Pedersen, Lotte Bang

AU - Larsen, Lars Allan

AU - Christensen, Søren Tvorup

PY - 2014

Y1 - 2014

N2 - Primary cilia are unique sensory organelles that coordinate a wide variety of different signaling pathways to control cellular processes during development and in tissue homeostasis. Defects in function or assembly of these antenna-like structures are therefore associated with a broad range of developmental disorders and diseases called ciliopathies. Recent studies have indicated a major role of different populations of cilia, including nodal and cardiac primary cilia, in coordinating heart development, and defects in these cilia are associated with congenital heart disease. Here, we present an overview of the role of nodal and cardiac primary cilia in heart development.

AB - Primary cilia are unique sensory organelles that coordinate a wide variety of different signaling pathways to control cellular processes during development and in tissue homeostasis. Defects in function or assembly of these antenna-like structures are therefore associated with a broad range of developmental disorders and diseases called ciliopathies. Recent studies have indicated a major role of different populations of cilia, including nodal and cardiac primary cilia, in coordinating heart development, and defects in these cilia are associated with congenital heart disease. Here, we present an overview of the role of nodal and cardiac primary cilia in heart development.

U2 - 10.4161/org.27483

DO - 10.4161/org.27483

M3 - Review

C2 - 24345806

SN - 1547-6278

VL - 10

SP - 108

EP - 125

JO - Organogenesis

JF - Organogenesis

IS - 1

ER -