Lars Hviid

2020

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it

Jensen, A. R., Adams, Y. & Hviid, L., 1 Jan 2020, In: Immunological Reviews.

Research output: Contribution to journal › Review › peer-review

17 Citations (Scopus)

2019

Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between Groups A, B, and C

Olsen, R. W., Ecklu-Mensah, G., Bengtsson, A., Ofori, M. F., Kusi, K. A., Koram, K. A., Hviid, L., Adams, Y. & Jensen, A. T. R., 1 Oct 2019, In: Infection and Immunity. 87, 10, e00224-19.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

3 Downloads (Pure)

Comprehensive analysis of Fc-mediated IgM binding to the Plasmodium falciparum erythrocyte membrane protein 1 family in three parasite clones

Quintana, M. D. P., Ecklu-Mensah, G., Tcherniuk, S. O., Ditlev, S. B., Oleinikov, A. V., Hviid, L. & Lopez-Perez, M., 1 Dec 2019, In: Scientific Reports. 9, 1, p. 6050

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Evasion of classical complement pathway activation on Plasmodium falciparum-infected erythrocytes opsonized by PfEMP1-specific IgG

Larsen, M. D., Quintana, M. D. P., Ditlev, S. B., Bayarri-Olmos, R., Ofori, M. F., Hviid, L. & Garred, P., 2019, In: Frontiers in Immunology. 9, 3088.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

36 Downloads (Pure)

Functional antibodies against placental malaria parasites are variant dependent and differ by geographic region

Doritchamou, J., Teo, A., Morrison, R., Arora, G., Kwan, J., Manzella-Lapeira, J., Medina-Maldonado, S., Langhorne, J., Hviid, L., Narum, D. L., Dicko, A., Fried, M. & Duffy, P. E., 2019, In: Infection and Immunity. 87, 7, e00865-18.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Human Vδ1⁺ T cells in the immune response to Plasmodium falciparum infection

Hviid, L., Smith-Togobo, C. & Willcox, B. E., 2019, In: Frontiers in Immunology. 10, 5 p., 259.

Research output: Contribution to journal › Review › peer-review

7 Citations (Scopus)

Looking for needles in the Plasmodial haystack

Hviid, L., 27 Mar 2019, In: mSphere. 4, 2, 3 p., e00146-19.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

36 Downloads (Pure)

2018

A vaccine targeted specifically to prevent cerebral malaria - is there hope?

Hviid, L., Lavstsen, T. & Jensen, A. T., 3 Jul 2018, In: Expert Review of Vaccines. 17, 7, p. 565-567 3 p.

Research output: Contribution to journal › Letter › peer-review

5 Citations (Scopus)

Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes

Ecklu-Mensah, G., Olsen, R. W., Bengtsson, A., Ofori, M. F., Hviid, L., Jensen, A. T. R. & Adams, Y., 2018, In: PLoS ONE. 13, 10, 12 p., e0204177.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

78 Downloads (Pure)

Etiology of placental Plasmodium falciparum malaria in African women

Ofori, M. F., Lamptey, H., Dickson, E. K., Kyei-Baafour, E. & Hviid, L., 20 Jun 2018, In: The Journal of Infectious Diseases. 218, 2, p. 277-281 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

31 Downloads (Pure)

IgG responses to the Plasmodium falciparum antigen VAR2CSA in Colombia are restricted to pregnancy and are not induced by exposure to Plasmodium vivax

Lopez-Perez, M., Larsen, M. D., Bayarri-Olmos, R., Ampomah, P., Stevenson, L., Arévalo-Herrera, M., Herrera, S. & Hviid, L., 1 Aug 2018, In: Infection and Immunity. 86, 8, e00136-18.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

32 Downloads (Pure)

Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation

Castberg, F. C., Maretty, L., Staalsoe, T., Hempel, C., Clasen-Linde, E., Hviid, L. & Kurtzhals, J. A. L., 16 Jan 2018, In: Malaria Journal. 17, 1, 12 p., 34.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

72 Downloads (Pure)

Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria

Partey, F. D., Castberg, F. C., Sarbah, E. W., Silk, S. E., Awandare, G. A., Draper, S. J., Opoku, N., Kweku, M., Ofori, M. F., Hviid, L. & Barfod, L., Jun 2018, In: PLOS ONE. 13, 6, 14 p., e0198371.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

34 Downloads (Pure)

Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools

Castberg, F. C., Sarbah, E. W., Koram, K. A., Opoku, N., Ofori, M. F., Styrishave, B., Hviid, L. & Kurtzhals, J. A. L., 11 Dec 2018, In: Malaria Journal. 17, 1, 464.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

54 Downloads (Pure)

Natural and vaccine-induced acquisition of cross-reactive IgG inhibiting ICAM-1-specific binding of a Plasmodium falciparum PfEMP1 subtype associated specifically with cerebral malaria

Olsen, R. W., Ecklu-Mensah, G., Bengtsson, A., Ofori, M. F., Lusingu, J. P. A., Castberg, F. C., Hviid, L., Adams, Y. & Jensen, A. T. R., 1 Apr 2018, In: Infection and Immunity. 86, 4, 17 p., e00622-17.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

62 Downloads (Pure)

2017

Dansk malariaforskning fra spæd begyndelse til international styrkeposition

Translated title of the contribution: Danish malaria research from the frail beginning to internationally acknowledged researchJepsen, M. P. G., Jepsen, S., Kurtzhals, J. & Hviid, L., 1 Mar 2017, In: Ugeskrift for Laeger. 179, 20, p. 866-869 V10160756.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Malaria parasite evasion of classical complement pathway attack

Larsen, M. D., Ditlev, S., Olmos, R. B., Ampomah, P., Ofori, M. F., Garred, P. & Hviid, L., 2017, In: Molecular Immunology. 89, p. 159-159

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

Lennartz, F., Adams, Y., Bengtsson, A., Olsen, R. W., Turner, L., Ndam, N. T., Ecklu-Mensah, G. D., Moussiliou, A., Ofori, M. F., Gamain, B., Lusingu, J. P., Petersen, J. E. V., Wang, C. W., Nunes-Silva, S., Jespersen, J. S., Lau, C. K. Y., Theander, T. G., Lavstsen, T., Hviid, L. & Higgins, M. K. & 1 others, Jensen, A. T. R., 8 Mar 2017, In: Cell Host & Microbe. 21, 3, p. 403-414 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

64 Citations (Scopus)

441 Downloads (Pure)

2016

Immunoglobulin M: restrainer of inflammation and mediator of immune evasion by Plasmodium falciparum malaria

Pleass, R. J., Moore, S. C., Stevenson, L. & Hviid, L., 1 Feb 2016, In: Trends in Parasitology. 32, 2, p. 108-119 12 p.

Research output: Contribution to journal › Review › peer-review

20 Citations (Scopus)

Orm i toilettet

Translated title of the contribution: Worms in the toiletHviid, L., Møller-Bisgaard, S. & Kurtzhals, J., 15 Feb 2016, In: Ugeskrift for Laeger. 178, 7, 1 p., V67428.

Research output: Contribution to journal › Journal article › Communication

2015

Investigating the function of F_c -specific binding of IgM to Plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosetting

Stevenson, L., Huda, P., Jeppesen, A., Laursen, E. T. F., Rowe, J. A., Craig, A., Streicher, W., Barfod, L. & Hviid, L., 1 Jun 2015, In: Cellular Microbiology. 17, 6, p. 819-31 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

1310 Downloads (Pure)

Multiple Plasmodium falciparum erythrocyte membrane protein 1 variants per genome can bind IgM via its Fc fragment Fcμ

Jeppesen, A., Ditlev, S. B., Soroka, V., Stevenson, E. K., Turner, L., Dzikowski, R., Hviid, L. & Barfod, L., 2015, In: Infection and Immunity. 83, 10, p. 3972-81 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

1030 Downloads (Pure)

PfEMP1 – a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis

Hviid, L. & Jensen, A. T. R., 1 Apr 2015, Advances in Parasitology. Rollinson, D. & Stothard, J. R. (eds.). Vol. 88. p. 51-84 34 p. (Advances in Parasitology).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

63 Citations (Scopus)

Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed

Subramani, R., Quadt, K., Jeppesen, A. E., Hempel, C., Petersen, J. E. V., Hassenkam, T., Hviid, L. & Barfod, L. K., 2015, In: mBio. 6, 5, 7 p., e01456-15.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

571 Downloads (Pure)

Rifins, rosetting, and red blood cells

Wang, C. W. & Hviid, L., 1 Jul 2015, In: Trends in Parasitology. 31, 7, p. 285-6 2 p.

Research output: Contribution to journal › Journal article › Commissioned › peer-review

9 Citations (Scopus)

Trying to remember: immunological B cell memory to malaria

Hviid, L., Barfod, L. & Fowkes, F. J. I., 1 Mar 2015, In: Trends in Parasitology. 31, 3, p. 89-94 6 p.

Research output: Contribution to journal › Review › peer-review

27 Citations (Scopus)

α2-macroglobulin can crosslink multiple Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) molecules and may facilitate adhesion of parasitized erythrocytes

Stevenson, L., Laursen, E., Cowan, G. J., Bandoh, B., Barfod, L., Cavanagh, D. R., Andersen, G. R. & Hviid, L., 1 Jul 2015, In: P L o S Pathogens. 11, 7, p. 1-19 19 p., e1005022.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

1126 Downloads (Pure)

2014

B-cell responses to pregnancy-restricted and -unrestricted Plasmodium falciparum erythrocyte membrane protein 1 antigens in Ghanaian women naturally exposed to malaria parasites

Ampomah, P., Stevenson, L., Ofori, M. F., Barfod, L. & Hviid, L., May 2014, In: Infection and Immunity. 82, 5, p. 1860-71 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

1794 Downloads (Pure)

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites

Sleebs, B. E., Lopaticki, S., Marapana, D. S., O'Neill, M. T., Rajasekaran, P., Gazdik, M., Günther, S., Whitehead, L. W., Lowes, K. N., Barfod, L., Hviid, L., Shaw, P. J., Hodder, A. N., Smith, B. J., Cowman, A. F. & Boddey, J. A., 2014, In: P L o S Biology. 12, 7, p. e1001897

Research output: Contribution to journal › Journal article › Research › peer-review

81 Citations (Scopus)

1834 Downloads (Pure)

Kinetics of B Cell responses to Plasmodium falciparum erythrocyte membrane protein 1 in Ghanaian women naturally exposed to malaria parasites

Ampomah, P., Stevenson, L., Ofori, M. F., Barfod, L. & Hviid, L., 1 Jun 2014, In: Journal of Immunology. 192, 11, p. 5236-44 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

1233 Downloads (Pure)

Modeling malaria infection and immunity against variant surface antigens in Príncipe island, West Africa

Bandeiras, C., Trovoada, M. J., Gonçalves, L. A., Marinho, C. R. F., Turner, L., Hviid, L., Penha-Gonçalves, C. & Gomes, M. G. M., 10 Feb 2014, In: PloS one. 9, 2, p. e88110

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

1091 Downloads (Pure)

2013

A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies

Bengtsson, A., Joergensen, L., Rask, T. S., Olsen, R. W., Andersen, M. A., Turner, L., Theander, T. G., Hviid, L., Higgins, M. K., Craig, A., Brown, A. & Jensen, A. T. R., 1 Jan 2013, In: Journal of Immunology. 190, 1, p. 240-9 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

71 Citations (Scopus)

23 Downloads (Pure)

Cytokine response to pregnancy-associated recrudescence of Plasmodium berghei infection in mice with pre-existing immunity to malaria

Megnekou, R., Staalsoe, T. & Hviid, L., 1 Nov 2013, In: Malaria Journal. 12, 1, p. 387

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Plasmodium falciparum Expressing Domain Cassette 5 Type PfEMP1 (DC5-PfEMP1) Bind PECAM1

Berger, S. S., Turner, L., Wang, C. W., Petersen, J. E. V., Kraft, M., Lusingu, J. P. A., Mmbando, B., Marquard, A. M., Bengtsson, D. B. A. C., Hviid, L., Nielsen, M. A., Theander, T. G. & Lavstsen, T., 9 Jul 2013, In: PloS one. 8, 7, p. e69117

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

Transfected HEK293 Cells Expressing Functional Recombinant Intercellular Adhesion Molecule 1 (ICAM-1) - A Receptor Associated with Severe Plasmodium falciparum Malaria

Bengtsson, A., Joergensen, L., Barbati, Z. R., Craig, A., Hviid, L. & Jensen, A. T. R., 25 Jul 2013, In: PLOS ONE. 8, 7, p. e69999

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

16 Downloads (Pure)

2012

Aligned hemozoin crystals in curved clusters in malarial red blood cells revealed by nanoprobe X-ray Fe fluorescence and diffraction

Kapishnikov, S., Berthing, T., Hviid, L., Dierolf, M., Menzel, A., Pfeiffer, F., Als-Nielsen, J. & Leiserowitz, L., 10 Jul 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11184-7 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia

Boeuf, P. S., Loizon, S., Awandare, G. A., Tetteh, J. K., Addae, M. M., Adjei, G. O., Goka, B., Kurtzhals, J. A., Puijalon, O., Hviid, L., Akanmori, B. D. & Behr, C., 2012, In: Malaria Journal. 11, 1, p. 253

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

The density of knobs on Plasmodium falciparum-infected erythrocytes depends on developmental age and varies among isolates

Quadt, K. A., Barfod, L., Andersen, D., Bruun, J., Gyan, B., Hassenkam, T., Ofori, M. F. & Hviid, L., 20 Sept 2012, In: P L o S One. 7, 9, p. e45658

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

2011

Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1

Barfod, L., Dalgaard, M. B., Pleman, S. T., Ofori, M. F., Pleass, R. J. & Hviid, L., 26 Jul 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 30, p. 12485-90 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

58 Citations (Scopus)

The case for PfEMP1-based vaccines to protect pregnant women against Plasmodium falciparum malaria

Hviid, L., Oct 2011, In: Expert Review of Vaccines. 10, 10, p. 1405-14 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

2010

Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants

Barfod, L., Dobrilovic, T., Magistrado, P., Khunrae, P., Viwami, F., Bruun, J., Dahlbäck, M., Bernasconi, N. L., Fried, M., John, D., Duffy, P. E., Salanti, A., Lanzavecchia, A., Lim, C. T., Ndam, N. T., Higgins, M. K. & Hviid, L., 15 Dec 2010, In: Journal of Immunology. 185, 12, p. 7553-61 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

43 Citations (Scopus)

Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children

Cham, G. K. K., Turner, L., Kurtis, J. D., Mutabingwa, T., Fried, M., Jensen, A. T. R., Lavstsen, T., Hviid, L., Duffy, P. E. & Theander, T. G., Nov 2010, In: Infection and Immunity. 78, 11, p. 4653-9 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

11 Downloads (Pure)

Immune selection and within-host competition can structure the repertoire of variant surface antigens in Plasmodium falciparum -a mathematical model

van Noort, S. P., Nunes, M. C., Weedall, G. D., Hviid, L. & Gomes, M. G. M., 2010, In: PLoS ONE. 5, 3, p. e9778

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Of mice and women: rodent models of placental malaria

Hviid, L., Marinho, C. R. F., Staalsoe, T. & Penha-Gonçalves, C., Aug 2010, In: Trends in Parasitology. 26, 8, p. 412-9 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs

Joergensen, L. M., Salanti, A., Dobrilovic, T., Barfod, L., Hassenkam, T., Theander, T. G., Hviid, L. & Arnot, D. E., 2010, In: Malaria Journal. 9, 1, p. 100

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development

Hviid, L., 2010, In: Human Vaccines. 6, 1, p. 84-89 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

55 Citations (Scopus)

2009

Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens

Soerli, J., Barfod, L., Lavstsen, T., Bernasconi, N. L., Lanzavecchia, A. & Hviid, L., 2009, In: Parasite Immunology. 31, 6, p. 341-6 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Pregnancy-associated malaria in a rural community of Ghana

Ofori, M., Ansah, E., Agyepong, I., Ofori-Adjei, D., Hviid, L. & Akanmori, B., 2009, In: Ghana Medical Journal. 43, 1, p. 13-8 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Unraveling the impact of malaria exposure before birth

Hviid, L., 2009, In: PLoS Medicine. 6, 7, p. e1000117

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Variant-specific immunity to Plasmodium berghei in pregnant mice

Megnekou, R., Hviid, L. & Staalsoe, T., 2009, In: Infection and Immunity. 77, 5, p. 1827-34 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Lars Hviid

Research output

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