Research output per year
Research output per year
Personal profile
Short presentation
My research is focused on malaria to investigate how malaria parasites inside erythrocytes interact with the host. In particular, I focus on malaria parasites binding to ICAM-1 expressed at the brain endothelium and on the development of a cerebral malaria vaccine.
Current research
Keywords
Receptor-ligand interactions; recombinant protein expression; antigen design; poly- and monoclonal antibody generation and characterization; immunoassays; cell-to-cell adhesion assays; flow cytometry; malaria infected erythrocytes; primary and immortalized cells; vaccine development; VLP
CV
2010 – 2014. PhD, Centre for Medical Parasitology, Faculty of Health and Medical Sciences, University of Copenhagen.
Scientific focus: Vaccine development against cerebral malaria.
2006 – 2008. MSc in Biotechnology, The Technical University of Denmark (DTU).
Scientific focus: Biomedical microbiology and immunology.
2002 – 2006. Engineer in Food Science, The Technical University of Denmark (DTU).
Scientific focus: General food science and food microbiology.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Faculty of Health and Medical Sciences
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Research output
- 11 Journal article
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Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria
Lennartz, F., Adams, Y., Bengtsson, A., Olsen, R. W., Turner, L., Ndam, N. T., Ecklu-Mensah, G. D., Moussiliou, A., Ofori, M. F., Gamain, B., Lusingu, J. P., Petersen, J. E. V., Wang, C. W., Nunes-Silva, S., Jespersen, J. S., Lau, C. K. Y., Theander, T. G., Lavstsen, T., Hviid, L., Higgins, M. K., & 1 others, 8 Mar 2017, In: Cell Host & Microbe. 21, 3, p. 403-414 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mapping the binding site of a cross-reactive Plasmodium falciparum PfEMP1 monoclonal antibody inhibitory of ICAM-1 binding
Lennartz, F., Bengtsson, A., Olsen, R. W., Joergensen, L., Brown, A., Remy, L., Man, P., Forest, E., Barfod, L. K., Adams, Y., Higgins, M. K. & Jensen, A. T. R., 1 Oct 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 7, p. 3273-83 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
18 Citations (Scopus)42 Downloads (Pure) -
Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between Groups A, B, and C
Olsen, R. W., Ecklu-Mensah, G., Bengtsson, A., Ofori, M. F., Kusi, K. A., Koram, K. A., Hviid, L., Adams, Y. & Jensen, A. T. R., 1 Oct 2019, In: Infection and Immunity. 87, 10, e00224-19.Research output: Contribution to journal › Journal article › Research › peer-review
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Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes
Ecklu-Mensah, G., Olsen, R. W., Bengtsson, A., Ofori, M. F., Hviid, L., Jensen, A. T. R. & Adams, Y., 2018, In: PLoS ONE. 13, 10, 12 p., e0204177.Research output: Contribution to journal › Journal article › Research › peer-review
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Natural and vaccine-induced acquisition of cross-reactive IgG inhibiting ICAM-1-specific binding of a Plasmodium falciparum PfEMP1 subtype associated specifically with cerebral malaria
Olsen, R. W., Ecklu-Mensah, G., Bengtsson, A., Ofori, M. F., Lusingu, J. P. A., Castberg, F. C., Hviid, L., Adams, Y. & Jensen, A. T. R., 1 Apr 2018, In: Infection and Immunity. 86, 4, 17 p., e00622-17.Research output: Contribution to journal › Journal article › Research › peer-review
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An analysis of the binding characteristics of a panel of recently selected ICAM-1 binding Plasmodium falciparum patient isolates
Madkhali, A. M., Alkurbi, M. O., Szestak, T., Bengtsson, A., Patil, P. R., Wu, Y., Alharthi, S., Jensen, A. T. R., Pleass, R. & Craig, A. G., 31 Oct 2014, In: PLOS ONE. 9, 10, 8 p., e111518.Research output: Contribution to journal › Journal article › Research › peer-review
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A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies
Bengtsson, A., Joergensen, L., Rask, T. S., Olsen, R. W., Andersen, M. A., Turner, L., Theander, T. G., Hviid, L., Higgins, M. K., Craig, A., Brown, A. & Jensen, A. T. R., 1 Jan 2013, In: Journal of Immunology. 190, 1, p. 240-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transfected HEK293 Cells Expressing Functional Recombinant Intercellular Adhesion Molecule 1 (ICAM-1) - A Receptor Associated with Severe Plasmodium falciparum Malaria
Bengtsson, A., Joergensen, L., Barbati, Z. R., Craig, A., Hviid, L. & Jensen, A. T. R., 25 Jul 2013, In: PLOS ONE. 8, 7, p. e69999Research output: Contribution to journal › Journal article › Research › peer-review