Immunoglobulin M: restrainer of inflammation and mediator of immune evasion by Plasmodium falciparum malaria

TY - JOUR

T1 - Immunoglobulin M

T2 - restrainer of inflammation and mediator of immune evasion by Plasmodium falciparum malaria

AU - Pleass, Richard J

AU - Moore, Shona C

AU - Stevenson, Liz

AU - Hviid, Lars

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Immunoglobulin M (IgM) is an ancient antibody class that is found in all vertebrates, with the exception of coelacanths, and is indispensable in both innate and adaptive immunity. The equally ancient human malaria parasite, Plasmodium falciparum, formed an intimate relationship with IgM with which it co-evolved. In this article, we discuss the association between IgM and human malaria parasites, building on several recent publications that implicate IgM as a crucial molecule that determines both host and parasite survival. Consequently, a better understanding of this association may lead to the development of improved intervention strategies.

AB - Immunoglobulin M (IgM) is an ancient antibody class that is found in all vertebrates, with the exception of coelacanths, and is indispensable in both innate and adaptive immunity. The equally ancient human malaria parasite, Plasmodium falciparum, formed an intimate relationship with IgM with which it co-evolved. In this article, we discuss the association between IgM and human malaria parasites, building on several recent publications that implicate IgM as a crucial molecule that determines both host and parasite survival. Consequently, a better understanding of this association may lead to the development of improved intervention strategies.

U2 - 10.1016/j.pt.2015.09.007

DO - 10.1016/j.pt.2015.09.007

M3 - Review

C2 - 26597020

SN - 1471-4922

VL - 32

SP - 108

EP - 119

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 2

ER -