Etiology of placental Plasmodium falciparum malaria in African women

Michael F Ofori; Helena Lamptey; Emmanuel K Dickson; Eric Kyei-Baafour; Lars Hviid

doi:10.1093/infdis/jiy168

Etiology of placental Plasmodium falciparum malaria in African women

Michael F Ofori, Helena Lamptey, Emmanuel K Dickson, Eric Kyei-Baafour, Lars Hviid

5 Citations (Scopus)

31 Downloads (Pure)

Abstract

Plasmodium falciparum parasites causing placental malaria express the VAR2CSA type of the clonally variant antigen family erythrocyte membrane protein 1 (PfEMP1). This enables evasion of preexisting immunity and results in placental accumulation of infected erythrocytes. We present data on seasonal variation in levels of VAR2CSA-specific immunoglobulin G (IgG) and IgG specific for a placental malaria-unrelated PfEMP1 protein among Ghanaian women at their first antenatal visit. Our results indicate that placental malaria does not require recent exposure to infected mosquitoes, in contrast to malaria in general. This has implications for the impact of insecticide-treated bed nets on placental malaria incidence and for antenatal care in woman with preexisting immunity.

Original language	English
Journal	The Journal of Infectious Diseases
Volume	218
Issue number	2
Pages (from-to)	277-281
Number of pages	5
ISSN	0022-1899
DOIs	https://doi.org/10.1093/infdis/jiy168
Publication status	Published - 20 Jun 2018

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Etiology of Placental Plasmodium falciparum Malaria in African WomenFinal published version, 922 KBLicence: CC BY-NC-ND

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title = "Etiology of placental Plasmodium falciparum malaria in African women",

abstract = "Plasmodium falciparum parasites causing placental malaria express the VAR2CSA type of the clonally variant antigen family erythrocyte membrane protein 1 (PfEMP1). This enables evasion of preexisting immunity and results in placental accumulation of infected erythrocytes. We present data on seasonal variation in levels of VAR2CSA-specific immunoglobulin G (IgG) and IgG specific for a placental malaria-unrelated PfEMP1 protein among Ghanaian women at their first antenatal visit. Our results indicate that placental malaria does not require recent exposure to infected mosquitoes, in contrast to malaria in general. This has implications for the impact of insecticide-treated bed nets on placental malaria incidence and for antenatal care in woman with preexisting immunity.",

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T1 - Etiology of placental Plasmodium falciparum malaria in African women

AU - Ofori, Michael F

AU - Lamptey, Helena

AU - Dickson, Emmanuel K

AU - Kyei-Baafour, Eric

AU - Hviid, Lars

PY - 2018/6/20

Y1 - 2018/6/20

N2 - Plasmodium falciparum parasites causing placental malaria express the VAR2CSA type of the clonally variant antigen family erythrocyte membrane protein 1 (PfEMP1). This enables evasion of preexisting immunity and results in placental accumulation of infected erythrocytes. We present data on seasonal variation in levels of VAR2CSA-specific immunoglobulin G (IgG) and IgG specific for a placental malaria-unrelated PfEMP1 protein among Ghanaian women at their first antenatal visit. Our results indicate that placental malaria does not require recent exposure to infected mosquitoes, in contrast to malaria in general. This has implications for the impact of insecticide-treated bed nets on placental malaria incidence and for antenatal care in woman with preexisting immunity.

AB - Plasmodium falciparum parasites causing placental malaria express the VAR2CSA type of the clonally variant antigen family erythrocyte membrane protein 1 (PfEMP1). This enables evasion of preexisting immunity and results in placental accumulation of infected erythrocytes. We present data on seasonal variation in levels of VAR2CSA-specific immunoglobulin G (IgG) and IgG specific for a placental malaria-unrelated PfEMP1 protein among Ghanaian women at their first antenatal visit. Our results indicate that placental malaria does not require recent exposure to infected mosquitoes, in contrast to malaria in general. This has implications for the impact of insecticide-treated bed nets on placental malaria incidence and for antenatal care in woman with preexisting immunity.

U2 - 10.1093/infdis/jiy168

DO - 10.1093/infdis/jiy168

M3 - Journal article

C2 - 29579263

SN - 0022-1899

VL - 218

SP - 277

EP - 281

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

IS - 2

ER -

Etiology of placental Plasmodium falciparum malaria in African women

Abstract

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