Trying to remember: immunological B cell memory to malaria

Lars Hviid; Lea Barfod; Freya J I Fowkes

doi:10.1016/j.pt.2014.12.009

Trying to remember: immunological B cell memory to malaria

Lars Hviid, Lea Barfod, Freya J I Fowkes

27 Citations (Scopus)

Abstract

In areas with stable transmission of Plasmodium falciparum parasites, even partially-protective immunity to malaria is acquired only after years of exposure and several infections. It has long been speculated that malaria parasites are directly able to undermine the establishment and maintenance of immunological memory, and that the often transient antibody responses to this parasite are evidence of such a dysfunction. We propose that long-lived antibody responses may not always be a prerequisite for protection, and that antibody longevity varies in an exposure- and age-dependent manner.

Original language	English
Journal	Trends in Parasitology
Volume	31
Issue number	3
Pages (from-to)	89-94
Number of pages	6
ISSN	1471-4922
DOIs	https://doi.org/10.1016/j.pt.2014.12.009
Publication status	Published - 1 Mar 2015

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title = "Trying to remember: immunological B cell memory to malaria",

abstract = "In areas with stable transmission of Plasmodium falciparum parasites, even partially-protective immunity to malaria is acquired only after years of exposure and several infections. It has long been speculated that malaria parasites are directly able to undermine the establishment and maintenance of immunological memory, and that the often transient antibody responses to this parasite are evidence of such a dysfunction. We propose that long-lived antibody responses may not always be a prerequisite for protection, and that antibody longevity varies in an exposure- and age-dependent manner.",

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AU - Hviid, Lars

AU - Barfod, Lea

AU - Fowkes, Freya J I

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N2 - In areas with stable transmission of Plasmodium falciparum parasites, even partially-protective immunity to malaria is acquired only after years of exposure and several infections. It has long been speculated that malaria parasites are directly able to undermine the establishment and maintenance of immunological memory, and that the often transient antibody responses to this parasite are evidence of such a dysfunction. We propose that long-lived antibody responses may not always be a prerequisite for protection, and that antibody longevity varies in an exposure- and age-dependent manner.

AB - In areas with stable transmission of Plasmodium falciparum parasites, even partially-protective immunity to malaria is acquired only after years of exposure and several infections. It has long been speculated that malaria parasites are directly able to undermine the establishment and maintenance of immunological memory, and that the often transient antibody responses to this parasite are evidence of such a dysfunction. We propose that long-lived antibody responses may not always be a prerequisite for protection, and that antibody longevity varies in an exposure- and age-dependent manner.

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DO - 10.1016/j.pt.2014.12.009

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EP - 94

JO - Trends in Parasitology

JF - Trends in Parasitology

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Trying to remember: immunological B cell memory to malaria

Abstract

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