Human Vδ1+ T cells in the immune response to Plasmodium falciparum infection

Lars Hviid; Cecilia Smith-Togobo; Benjamin E Willcox

doi:10.3389/fimmu.2019.00259

Human Vδ1⁺ T cells in the immune response to Plasmodium falciparum infection

Lars Hviid^*, Cecilia Smith-Togobo, Benjamin E Willcox

^*Corresponding author for this work

7 Citations (Scopus)

Abstract

Naturally acquired protective immunity to Plasmodium falciparum malaria is mainly antibody-mediated. However, other cells of the innate and adaptive immune system also play important roles. These include so-called unconventional T cells, which express a aã T-cell receptor (TCR) rather than the δ TCR expressed by the majority of T cells-the conventional T cells. The aã T-cell compartment can be divided into distinct subsets. One expresses a TCR involving Vδ9 and Vä2, while another major subset uses instead a TCR composed of Vä1 paired with one of several types of ã chains. The former of these subsets uses a largely semi-invariant TCR repertoire and responds in an innate-like fashion to pyrophosphate antigens generated by various stressed host cells and infectious pathogens, including P. falciparum. In this short review, we focus instead on the Vä1 subset, which appears to have a more adaptive immunobiology, but which has been much less studied in general and in malaria in particular. We discuss the evidence that Vä1+ cells do indeed play a role in malaria and speculate on the function and specificity of this cell type, which is increasingly attracting the attention of immunologists.

Original language	English
Article number	259
Journal	Frontiers in Immunology
Volume	10
Number of pages	5
ISSN	1664-3224
DOIs	https://doi.org/10.3389/fimmu.2019.00259
Publication status	Published - 2019

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Cite this

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title = "Human Vδ1+ T cells in the immune response to Plasmodium falciparum infection",

abstract = "Naturally acquired protective immunity to Plasmodium falciparum malaria is mainly antibody-mediated. However, other cells of the innate and adaptive immune system also play important roles. These include so-called unconventional T cells, which express a a{\~a} T-cell receptor (TCR) rather than the δ TCR expressed by the majority of T cells-the conventional T cells. The a{\~a} T-cell compartment can be divided into distinct subsets. One expresses a TCR involving Vδ9 and V{\"a}2, while another major subset uses instead a TCR composed of V{\"a}1 paired with one of several types of {\~a} chains. The former of these subsets uses a largely semi-invariant TCR repertoire and responds in an innate-like fashion to pyrophosphate antigens generated by various stressed host cells and infectious pathogens, including P. falciparum. In this short review, we focus instead on the V{\"a}1 subset, which appears to have a more adaptive immunobiology, but which has been much less studied in general and in malaria in particular. We discuss the evidence that V{\"a}1+ cells do indeed play a role in malaria and speculate on the function and specificity of this cell type, which is increasingly attracting the attention of immunologists.",

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doi = "10.3389/fimmu.2019.00259",

language = "English",

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journal = "Frontiers in Immunology",

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T1 - Human Vδ1+ T cells in the immune response to Plasmodium falciparum infection

AU - Hviid, Lars

AU - Smith-Togobo, Cecilia

AU - Willcox, Benjamin E

PY - 2019

Y1 - 2019

N2 - Naturally acquired protective immunity to Plasmodium falciparum malaria is mainly antibody-mediated. However, other cells of the innate and adaptive immune system also play important roles. These include so-called unconventional T cells, which express a aã T-cell receptor (TCR) rather than the δ TCR expressed by the majority of T cells-the conventional T cells. The aã T-cell compartment can be divided into distinct subsets. One expresses a TCR involving Vδ9 and Vä2, while another major subset uses instead a TCR composed of Vä1 paired with one of several types of ã chains. The former of these subsets uses a largely semi-invariant TCR repertoire and responds in an innate-like fashion to pyrophosphate antigens generated by various stressed host cells and infectious pathogens, including P. falciparum. In this short review, we focus instead on the Vä1 subset, which appears to have a more adaptive immunobiology, but which has been much less studied in general and in malaria in particular. We discuss the evidence that Vä1+ cells do indeed play a role in malaria and speculate on the function and specificity of this cell type, which is increasingly attracting the attention of immunologists.

AB - Naturally acquired protective immunity to Plasmodium falciparum malaria is mainly antibody-mediated. However, other cells of the innate and adaptive immune system also play important roles. These include so-called unconventional T cells, which express a aã T-cell receptor (TCR) rather than the δ TCR expressed by the majority of T cells-the conventional T cells. The aã T-cell compartment can be divided into distinct subsets. One expresses a TCR involving Vδ9 and Vä2, while another major subset uses instead a TCR composed of Vä1 paired with one of several types of ã chains. The former of these subsets uses a largely semi-invariant TCR repertoire and responds in an innate-like fashion to pyrophosphate antigens generated by various stressed host cells and infectious pathogens, including P. falciparum. In this short review, we focus instead on the Vä1 subset, which appears to have a more adaptive immunobiology, but which has been much less studied in general and in malaria in particular. We discuss the evidence that Vä1+ cells do indeed play a role in malaria and speculate on the function and specificity of this cell type, which is increasingly attracting the attention of immunologists.

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